Recombinant Anti-CD22 (Epitope A x Epitope B) Biparatopic Antibody, Tandem scFv (CAT#: VS-0525-YC201)

• Host Animal 1
• Human

• Host Animal 2
• Mouse

• Specificity
• Human CD22

• Species Reactivity
• Human

• Type
• Tandem scFv

• Valency
• 1 + 1

• Epitope 1
• The first N-terminal domain (epitope A)

• Epitope 2
• The third extracellular domain (epitope B)

• Purity
• >90%

• Purification
• Affinity purified

• Applications
• ELISA, FC, ICC, IF, IP, Neut

• Concentration
• Lot specific

• Buffer
• PBS, pH 7.4

• Preservative
• No preservatives

• Storage
• Store at 4°C for short term. Aliquot and store at -20°C for long term. Avoid freeze-thaw cycles.

• Long Name
• CD22 Molecule

• Introduction
• CD22 or cluster of differentiation-22, is a molecule belonging to the SIGLEC family of lectins. It is found on the surface of mature B cells and to a lesser extent on some immature B cells. Generally speaking, CD22 is a regulatory molecule that prevents the overactivation of the immune system and the development of autoimmune diseases. CD22 is a sugar binding transmembrane protein, which specifically binds sialic acid with an immunoglobulin (Ig) domain located at its N-terminus. The presence of Ig domains makes CD22 a member of the immunoglobulin superfamily. CD22 functions as an inhibitory receptor for B cell receptor (BCR) signalling.

• Alternative Names
• SIGLEC2; SIGLEC-2; B-cell receptor CD22; B-lymphocyte cell adhesion molecule; BL-CAM; CD22 antigen; T-cell surface antigen Leu-14; sialic acid-binding Ig-like lectin 2

• Gene ID
• 933

• UniProt ID
• P20273

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