Anti-CD22 Antibody Prodrug, Protease Activated (VS-1025-YC100)

Name: Anti-CD22 Antibody Prodrug, Protease Activated (VS-1025-YC100)
SKU: VS-1025-YC100
Rating: 5 (1 reviews)

CAT#: VS-1025-YC100

The Anti-CD22 Antibody Prodrug, Protease Activated (VS-1025-YC100) is an antibody prodrug comprised of a recombinant human antibody targeting human CD22, linked to a masking peptide that conceals the active antigen-binding site via a protease-cleavable linker. The mask peptide is recombinantly attached to the amino terminus of either the light or heavy chain of the antibody, designed to block access to the antigen-binding site and physically prevent the antibody from binding to CD22 protein. Once the masking peptide is cleaved by matrix metalloproteinases (MMPs), the prodrug is activated, allowing the unmasked monoclonal antibody component to bind to CD22 effectively. CD22 is a transmembrane adhesion molecule expressed on the surface of mature B-cells and is a significant therapeutic target in B-cell malignancies like B-cell lymphomas and leukemias. It acts as an inhibitory receptor, regulating B-cell signaling and survival. CD22-targeted therapies, such as antibody-drug conjugates, are used to deliver cytotoxic payloads directly to the cancer cell.

Gene Expression

Normal Tissue Figure 1 Lymph node

Germinal center cells
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2418/6101_A_7_8.jpg

Normal Tissue Figure 2 Spleen

Cells in red pulp
Staining: Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous
Cells in white pulp
Staining: High
Intensity: Strong
Quantity: 75%-25%
Location: Cytoplasmic/membranous

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2418/6101_B_7_4.jpg

RNA Expression Figure 3 RNA cell line category: Cell line enhanced (Daudi, REH, U-698, WM-115)

Cell lines ordered by descending RNA expression order.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000012124-CD22

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Specifications

Host Animal
Human

Applications
In situ zymography (ISZ), Cytotoxicity assay (Cyt), Functional assay

Specificity
Human CD22

Target
CD22

Species Reactivity
Human

Isotype
IgG

Masking Approach
Affinity mask

Mask
A synthetic peptide

Protease Cleavable Linker
MMP-cleavable linker

Protease Substrate
MMPs

Purification
Protein A purified

Buffer
PBS, pH 7.4

Preservative
No preservatives

Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Target

Introduction
CD22 (CD22 Molecule) is a Protein Coding gene. Diseases associated with CD22 include refractory hematologic cancer and colon lymphoma. Among its related pathways are Immune System and Downstream signaling events of B Cell Receptor (BCR). GO annotations related to this gene include carbohydrate binding. An important paralog of this gene is VCAM1.

Alternative Names
CD22 Molecule; CD22 Antigen; Sialic Acid Binding Ig-Like Lectin 2; Sialic Acid-Binding Ig-Like Lectin 2; SIGLEC-2; SIGLEC2; BL-CAM

Gene ID
933

UniProt ID
P20273

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Downloadable Resources

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Datasheet

Datasheet - VS-1025-YC100.pdf

MSDS

MSDS - VS-1025-YC100.pdf

COA

Certificate of Analysis Lookup

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