Recombinant Anti-Human CD22 Antibody (Fc glycosylation)

Name: Recombinant Anti-Human CD22 Antibody (Fc glycosylation)
SKU: Gly-111LC
Rating: 5 (1 reviews)

CAT#: Gly-111LC

This product is a chimeric (mouse/human) monoclonal antibody with glycosylation site in Fc region. The clone with enhanced ADCC specifically binds human CD22 and can be potentially used in the treatment of lymphomas and other autoimmune diseases.

Gene Expression

Normal Tissue Figure 1 Lymph node

Germinal center cells
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2418/6101_A_7_8.jpg

Normal Tissue Figure 2 Spleen

Cells in red pulp
Staining: Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous
Cells in white pulp
Staining: High
Intensity: Strong
Quantity: 75%-25%
Location: Cytoplasmic/membranous

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2418/6101_B_7_4.jpg

RNA Expression Figure 3 RNA cell line category: Cell line enhanced (Daudi, REH, U-698, WM-115)

Cell lines ordered by descending RNA expression order.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000012124-CD22

❮

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Glyco-engineering

Glycosylation site
Asn297 in Fc region

Glycosylation Type
N-glycosylation

Activity
Enhanced ADCC

Specifications

Target
CD22 (Cluster of differentiation-22)

Host Species
Human

Derivation
Chimeric (mouse/human)

Type
Chimeric antibody (mouse/human)

Specificity
Human

Antibody Isotype
IgG1, κ

Clone
SM03

Expression Host
CHO

Applications
ELISA

Target

Alternative Names
CD22; CD22 molecule; SIGLEC2; SIGLEC-2; B-cell receptor CD22; BL-CAM; CD22 antigen; T-cell surface antigen Leu-14; B-lymphocyte cell adhesion molecule; sialic acid binding Ig-like lectin 2; sialic acid-binding Ig-like lectin 2

Related Disease
Lymphomas and other autoimmune diseases

Gene ID
933

UniProt ID
P20273

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Downloadable Resources

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Datasheet

Datasheet - Gly-111LC.pdf

MSDS

MSDS - Gly-111LC.pdf

COA

Certificate of Analysis Lookup

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