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CD6

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Anti-CD6 Recombinant Antibody Products

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For Research Use Only. Not For Clinical Use.


CD6 encodes a transmembrane glycoprotein expressed primarily on T-cells. It functions as a co-stimulatory receptor in T-cell activation and immune responses. CD6 binds to its ligand, CD166, on antigen-presenting cells, promoting immune cell adhesion and signaling. This interaction plays a role in T-cell proliferation and the development of autoimmune diseases. CD6 is also implicated in the regulation of inflammation and tissue repair.
CD6
Protein class

CD markers

Predicted location

Membrane, Secreted (different isoforms)

Single cell type specificity

Cell type enhanced (T-cells, NK-cells, dendritic cells, Plasma cells)

Immune cell specificity

Group enriched (memory CD4 T-cell, memory CD8 T-cell, naive CD4 T-cell, gdT-cell, T-reg, naive CD8 T-cell, MAIT T-cell)

Cell line specificity

Group enriched (JURKAT, MOLT-4)

Interaction

Interacts (via extracellular domain) with ALCAM/CD166 (via extracellular domain) (PubMed:15048703, PubMed:16352806, PubMed:16914752, PubMed:24945728, PubMed:26146185). Interacts with the TCR/CD3 complex subunit CD3E (PubMed:15294938). Interacts (via tyrosine phosphorylated C-terminus) with LCP2 (via SH2 domain) (PubMed:16914752). Interacts with VAV1 (By similarity). Interacts (via glycosylated extracellular domain) with LGALS1 and LGALS3 (PubMed:24945728). Interaction with LGALS1 or LGALS3 inhibits interaction with ALCAM (PubMed:24945728).

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