Afuco™ Anti-CD6 ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-247)
CAT#: AFC-TAB-247
This product is an ADCC enhanced antibody produced by our Afuco™ platform. Recombinant monoclonal antibody to CD6. It is a 'first in class' humanized IgG1 monoclonal antibody. It selectively targets CD6, a pan T cell marker involved in co-stimulation, adhesion and maturation of T cells.
Gene Expression
Normal Tissue
Figure 1 High expression in lymph node.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2489/6144_A_8_8_val_selected.jpg
Normal Tissue
Figure 2 Low expression in cerebral cortex.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2489/6144_B_8_5_val_selected.jpg
Normal Tissue
Figure 3 Colon
Enterocytes - Mucosal lymphoid cells Staining: High Intensity: Strong
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2489/6144_A_8_3.jpg
Normal Tissue
Figure 4 Lymph node
Non-germinal center cells Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2489/6144_A_7_8.jpg
Normal Tissue
Figure 5 Tonsil
Germinal center cells Staining: Medium Intensity: Strong Quantity: <25% Location: Cytoplasmic/ membranous Non-germinal center cells Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2489/6144_A_5_8.jpg
RNA Expression
Figure 6 RNA cell line category: Group enriched (JURKAT, MOLT-4)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000013725-CD6
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Specifications
- Immunogen
- The details of the immunogen for this antibody are not available.
- Host Species
- Human
- Derivation
- Humanized (from mouse)
- Type
- ADCC enhanced antibody
- Species Reactivity
- Human
- Applications
- IF, IP, Neut, FuncS, ELISA
- Conjugate
- Unconjugated
- Trade name
- Alzumab
- Generic Name
- Itolizumab
- Related Disease
- Psoriasis
Product Property
- Purity
- >95% by SDS-PAGE
- Storage
- Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Target
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Biosimilar Overview
Please refer to Itolizumab Overview to learn more about the mechanism of action, clinical projects, and approved drugs of Itolizumab.
Downloadable Resources
Download resources about recombinant antibody development and antibody engineering to boost your research.
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
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Protocol & Troubleshooting
We have outlined the assay protocols, covering reagents, solutions, procedures, and troubleshooting tips for common issues in order to better assist clients in conducting experiments with our products. View the full list of Protocol & Troubleshooting.
See other products for "CD6"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1416z | Mouse Anti-CD6 Recombinant Antibody (clone 23C11) | WB, FC, IHC, FuncS | Mouse IgG1, κ |
| FN-023CQ | Mouse Anti-CD6 Recombinant Antibody (clone CBL-1300) | FC, FuncS, WB | Mouse IgG1, κ |
| HPAB-N0043-YC | Human Anti-CD6 Recombinant Antibody (HPAB-N0043-YC) | ELISA, FC | Humanized IgG |
| VS3-QX193 | Mouse Anti-CD6 Recombinant Antibody (clone 6B9) | WB, IHC, ICC, FC, ELISA | Mouse IgG1 |
| VS3-QX194 | Mouse Anti-CD6 Recombinant Antibody (clone 12-D1) | WB, IHC, ICC, FC | Mouse IgG2b |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-247 | Anti-Human CD6 Recombinant Antibody (TAB-247) | WB, IF, IP, Neut, FuncS, ELISA, FC | IgG1 - kappa |
| TAB-325LC | Human Anti-CD6 Recombinant Antibody (TAB-325LC) | Cyt, FC | Humanized antibody |
| TAB-325LC-S(P) | Human Anti-CD6 Recombinant Antibody; scFv Fragment (TAB-325LC-S(P)) | FC, ELISA | Humanized scFv |
| TAB-325LC-F(E) | Human Anti-CD6 Recombinant Antibody; Fab Fragment (TAB-325LC-F(E)) | FC, ELISA | Humanized Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-399CQ | Mouse Anti-CD6 Recombinant Antibody (clone OX-124) | Block | Mouse IgG1, κ |
| NEUT-400CQ | Human Anti-CD6 Recombinant Antibody (clone OX-126) | FC, IHC, IF, FuncS, Depletion, Block | Human IgG1, κ |
| NEUT-401CQ | Rat Anti-Cd6 Recombinant Antibody (clone CBL311) | Block | Rat IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-0573 | Hi-Affi™ Rabbit Anti-CD6 Recombinant Antibody (clone DS573AB) | IHC-P, IP, WB | Rabbit IgG |
| MOR-0574 | Hi-Affi™ Rabbit Anti-CD6 Recombinant Antibody (clone DS574AB) | ELISA | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-N0043-YC-S(P) | Human Anti-CD6 Recombinant Antibody; scFv Fragment (HPAB-N0043-YC-S(P)) | ELISA, FC | Human scFv |
| HPAB-0009-YJ-S(P) | Mouse Anti-CD6 Recombinant Antibody (clone IOR T1); scFv Fragment | FuncS, IHC | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-N0043-YC-F(E) | Human Anti-CD6 Recombinant Antibody; Fab Fragment (HPAB-N0043-YC-F(E)) | ELISA, FC | Humanized Fab |
| HPAB-0009-YJ-F(E) | Mouse Anti-CD6 Recombinant Antibody (clone IOR T1); Fab Fragment | FuncS, IHC | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0225-XY63 | CytoStream™ Rat Anti-CD6 Recombinant Antibody (VS-0225-XY63) | FC | Rat IgG2a, lambda |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-FY90 | Mouse Anti-CD6 (clone IOR-T1) scFv-Fc Chimera | ELISA | Mouse IgG2a, scFv-Fc |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-YC197 | Recombinant Anti-CD6 Vesicular Antibody, EV Displayed (VS-0425-YC197) | ELISA, FC, Neut, Cell-uptake |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY1206 | Anti-CD6 Immunohistochemistry Kit | IHC |
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