Rabbit Anti-CTSD Recombinant Antibody (clone R07-3J3)
CAT#: VS3-XY3327
The rabbit recombinant antibody specifically recognizes CTSD (Cathepsin D), which plays a role in APP processing following cleavage and activation by ADAM30 which leads to APP degradation. It specifically reacts with human, mouse and rat CTSD. It has been tested using Western Blot, Immunohistochemistry-Paraffin, Immunoprecipitation, Flow cytometry, Immunocytochemistry or Immunofluorescence. The recommended dilutions of Western Blot, Immunohistochemistry-Paraffin, Immunoprecipitation, Flow cytometry and Immunofluorescence is 1/500-1/1000, 1/50-1/100, 1/20, 1/50-1/100 and 1/50-1/200, respectively.
Gene Expression
Normal Tissue
Figure 1 Cerebral cortex
Endothelial cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
Neuronal cells
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/109/2425_B_8_5.jpg
Normal Tissue
Figure 2 Lung
Macrophages
Staining: High
Intensity: Strong
Quantity:>75%
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/109/2425_A_2_4.jpg
Normal Tissue
Figure 3 Colon
Endocrine cells
Staining: Medium
Intensity: Moderate
Enterocytes
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Mucosal lymphoid cells
Staining: High
Intensity: Strong
Quantity: 75%-25%
Peripheral nerve/ganglion
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/109/2425_A_8_3.jpg
Normal Tissue
Figure 4 Liver
Hepatocytes
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/109/2425_A_9_4.jpg
Normal Tissue
Figure 5 Kidney
Cells in glomeruli
Staining: High
Intensity: Strong
Quantity: 75%-25%
Collecting ducts
Staining: High
Intensity: Strong
Quantity:>75%
Distal tubules
Staining: High
Intensity: Strong
Quantity:>75%
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/109/2425_A_8_5.jpg
Normal Tissue
Figure 6 Testis
Leydig cells
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Sertoli cells
Staining: Medium
Intensity: Strong
Quantity: <25%
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/109/2425_A_6_6.jpg
RNA Expression
Figure 7 RNA cell line category: Cell line enhanced (CAPAN-2, hTERT-RPE1, SK-BR-3)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000117984-CTSD
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Specifications
- Host Species
- Rabbit
- Type
- Rabbit IgG
- Specificity
- Human, Mouse and Rat CTSD
- Species Reactivity
- Human, Mouse, Rat
- Clone
- R07-3J3
- Applications
- WB, IHC-P, ICC, IF, IP, FC
- Related Disease
- Neuronal Ceroid Lipofuscinosis
Product Property
- Clonality
- Monoclonal
- Aggregation
- < 5%
- Format
- Liquid
- Buffer
- PBS (pH 7.4), 150 mM NaCl and 50% glycerol
- Preservative
- 0.02% sodium azide
- Storage
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- WB: 1/500-1/1000
IHC: 1/50-1/100
IF: 1/50-1/200
IP: 1/20
FC: 1/50-1/100
Target
- Alternative Names
- CPSD; CLN10; HEL-S-130P
- Gene ID
- 1509
- UniProt ID
- P07339
- Long Name
- Cathepsin D
- Cellular Localization
- Lysosome, Melanosome, Secreted
- Post Translation Modifications
- Glycosylation at Thr63, Asn134, and Asn263 (NX_P07339 [NX_P07339-1])
Ubiquitination at Lys28, Lys54, Lys184, and Lys348 (NX_P07339 [NX_P07339-1])
Modification sites at PhosphoSitePlus (P07339)
Glycosylation from GlyConnect CATD_HUMAN (1079)
Glycosylation from GlyGen (P07339) 8 sites, 44 N-linked glycans (2 sites), 3 O-linked glycans (4 sites)
- Protein Refseq
- NP_001900.1
- Function
- Acid protease active in intracellular protein breakdown. Plays a role in APP processing following cleavage and activation by ADAM30 which leads to APP degradation. Involved in the pathogenesis of several diseases such as breast cancer and possibly Alzheimer disease.
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
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Protocol & Troubleshooting
We have outlined the assay protocols, covering reagents, solutions, procedures, and troubleshooting tips for common issues in order to better assist clients in conducting experiments with our products. View the full list of Protocol & Troubleshooting.
Isotype Control
- CAT
- Product Name
Recommended Dilution Buffer
- CAT
- Product Name
Secondary Antibody
- CAT
- Product Name
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|---|---|---|---|
| DrMAB-1052 | Mouse Anti-CTSD Recombinant Antibody (clone YC031); Fab Fragment | ELISA | Mouse Fab |
| HPAB-0399-CN-F(E) | Human Anti-CTSD Recombinant Antibody; Fab Fragment (HPAB-0399-CN-F(E)) | ELISA, IF, IP, Neut | Human Fab |
| HPAB-0400-CN-F(E) | Human Anti-CTSD Recombinant Antibody; Fab Fragment (HPAB-0400-CN-F(E)) | ELISA, IF, IP, Neut | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-0867 | Hi-Affi™ Rabbit Anti-CTSD Recombinant Antibody (clone DS867AB) | ICC, IHC-P, WB | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0399-CN | Human Anti-CTSD Recombinant Antibody (HPAB-0399-CN) | ELISA, IF, IP, Neut | Human IgG1, λ |
| HPAB-0400-CN | Human Anti-CTSD Recombinant Antibody (HPAB-0400-CN) | ELISA, IF, IP, Neut | Human IgG1, λ |
| VS-0923-FY29 | Recombinant Mouse Anti-CTSD Antibody (VS-0923-FY29) | ELISA, IHC | Mouse IgG1 |
| VS-0923-FY30 | Recombinant Mouse Anti-CTSD Antibody (VS-0923-FY30) | ELISA, WB, IHC | Mouse IgG2a |
| VS13-YC271 | Rabbit Anti-CTSD Recombinant Antibody (VS13-YC271) | WB, ICC, IF, IHC-P, IP | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0399-CN-S(P) | Human Anti-CTSD Recombinant Antibody; scFv Fragment (HPAB-0399-CN-S(P)) | ELISA, IF, IP, Neut | Human scFv |
| HPAB-0400-CN-S(P) | Human Anti-CTSD Recombinant Antibody; scFv Fragment (HPAB-0400-CN-S(P)) | ELISA, IF, IP, Neut | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0424-XY74 | AbPlus™ Anti-CTSD Magnetic Beads (VS-0424-XY74) | IP, Protein Purification | |
| VS-0724-YC901 | AbPlus™ Anti-Ctsd Magnetic Beads (VS-0724-YC901) | IP, Protein Purification | |
| VS-0724-YC1036 | AbPlus™ Anti-CTSD Magnetic Beads (VS-0724-YC1036) | IP, Protein Purification |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY1782 | Anti-CTSD Immunohistochemistry Kit | IHC | |
| VS-0525-XY1783 | Anti-Mouse CTSD Immunohistochemistry Kit | IHC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0625-YC79 | Recombinant Anti-CTSD Eliminating Antibody, pH-Sensitive (VS-0625-YC79) | Antigen-Sweeping In Vivo. | Human IgG1 lambda |
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