Rabbit Anti-CTSD Recombinant Antibody (clone R07-3J3) (CAT#: VS3-XY3327)
The rabbit recombinant antibody specifically recognizes CTSD (Cathepsin D), which plays a role in APP processing following cleavage and activation by ADAM30 which leads to APP degradation. It specifically reacts with human, mouse and rat CTSD. It has been tested using Western Blot, Immunohistochemistry-Paraffin, Immunoprecipitation, Flow cytometry, Immunocytochemistry or Immunofluorescence. The recommended dilutions of Western Blot, Immunohistochemistry-Paraffin, Immunoprecipitation, Flow cytometry and Immunofluorescence is 1/500-1/1000, 1/50-1/100, 1/20, 1/50-1/100 and 1/50-1/200, respectively.
Specific Inquiry
Normal Tissue
RNA Expression
Figure 1 Cerebral cortex
(Endothelial cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
Neuronal cells
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/109/2425_B_8_5.jpg
(Endothelial cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
Neuronal cells
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/109/2425_B_8_5.jpg
Figure 2 Lung
(Macrophages
Staining: High
Intensity: Strong
Quantity:>75%)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/109/2425_A_2_4.jpg
(Macrophages
Staining: High
Intensity: Strong
Quantity:>75%)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/109/2425_A_2_4.jpg
Figure 3 Colon
(Endocrine cells
Staining: Medium
Intensity: Moderate
Enterocytes
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Mucosal lymphoid cells
Staining: High
Intensity: Strong
Quantity: 75%-25%
Peripheral nerve/ganglion
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/109/2425_A_8_3.jpg
(Endocrine cells
Staining: Medium
Intensity: Moderate
Enterocytes
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Mucosal lymphoid cells
Staining: High
Intensity: Strong
Quantity: 75%-25%
Peripheral nerve/ganglion
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/109/2425_A_8_3.jpg
Figure 4 Liver
(Hepatocytes
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/109/2425_A_9_4.jpg
(Hepatocytes
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/109/2425_A_9_4.jpg
Figure 5 Kidney
(Cells in glomeruli
Staining: High
Intensity: Strong
Quantity: 75%-25%
Collecting ducts
Staining: High
Intensity: Strong
Quantity:>75%
Distal tubules
Staining: High
Intensity: Strong
Quantity:>75%)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/109/2425_A_8_5.jpg
(Cells in glomeruli
Staining: High
Intensity: Strong
Quantity: 75%-25%
Collecting ducts
Staining: High
Intensity: Strong
Quantity:>75%
Distal tubules
Staining: High
Intensity: Strong
Quantity:>75%)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/109/2425_A_8_5.jpg
Figure 6 Testis
(Leydig cells
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Sertoli cells
Staining: Medium
Intensity: Strong
Quantity: <25%)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/109/2425_A_6_6.jpg
(Leydig cells
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Sertoli cells
Staining: Medium
Intensity: Strong
Quantity: <25%)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/109/2425_A_6_6.jpg
Figure 7 RNA cell line category: Cell line enhanced (CAPAN-2, hTERT-RPE1, SK-BR-3)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000117984-CTSD
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000117984-CTSD
Figure 7 RNA cell line category: Cell line enhanced (CAPAN-2, hTERT-RPE1, SK-BR-3)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000117984-CTSD
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000117984-CTSD
Specifications
- Host Species
- Rabbit
- Type
- Rabbit IgG
- Specificity
- Human, Mouse and Rat CTSD
- Species Reactivity
- Human, Mouse, Rat
- Clone
- R07-3J3
- Applications
- WB, IHC-P, ICC, IF, IP, FC
- Related Disease
- Neuronal Ceroid Lipofuscinosis
Product Property
- Clonality
- Monoclonal
- Aggregation
- < 5%
- Format
- Liquid
- Buffer
- PBS (pH 7.4), 150 mM NaCl and 50% glycerol
- Preservative
- 0.02% sodium azide
- Storage
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- WB: 1/500-1/1000
IHC: 1/50-1/100
IF: 1/50-1/200
IP: 1/20
FC: 1/50-1/100
Target
- Alternative Names
- CPSD; CLN10; HEL-S-130P
- Gene ID
- 1509
- UniProt ID
- P07339
- Long Name
- Cathepsin D
- Cellular Localization
- Lysosome, Melanosome, Secreted
- Post Translation Modifications
- Glycosylation at Thr63, Asn134, and Asn263 (NX_P07339 [NX_P07339-1])
Ubiquitination at Lys28, Lys54, Lys184, and Lys348 (NX_P07339 [NX_P07339-1])
Modification sites at PhosphoSitePlus (P07339)
Glycosylation from GlyConnect CATD_HUMAN (1079)
Glycosylation from GlyGen (P07339) 8 sites, 44 N-linked glycans (2 sites), 3 O-linked glycans (4 sites)
- Protein Refseq
- NP_001900.1
- Function
- Acid protease active in intracellular protein breakdown. Plays a role in APP processing following cleavage and activation by ADAM30 which leads to APP degradation. Involved in the pathogenesis of several diseases such as breast cancer and possibly Alzheimer disease.
Recommended Products
Isotype Control
Recommended Dilution Buffer
Secondary Antibody
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
See other products for "CTSD"
Fab Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| DrMAB-1052 | Mouse Anti-CTSD Recombinant Antibody (clone YC031); Fab Fragment | ELISA | Mouse Fab |
| HPAB-0399-CN-F(E) | Human Anti-CTSD Recombinant Antibody; Fab Fragment (HPAB-0399-CN-F(E)) | ELISA, IF, IP, Neut | Human Fab |
| HPAB-0400-CN-F(E) | Human Anti-CTSD Recombinant Antibody; Fab Fragment (HPAB-0400-CN-F(E)) | ELISA, IF, IP, Neut | Human Fab |
Recombinant Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-0335CT | Recombinant Mouse anti-Human CTSD Monoclonal antibody (5H3) | ELISA, WB | |
| VS3-QX302 | Mouse Anti-CTSD Recombinant Antibody (clone 892CT11.1.1) | WB, IHC | Mouse IgG1 |
| VS3-QX303 | Mouse Anti-CTSD Recombinant Antibody (clone 13F3) | WB, IHC | Mouse IgG1 |
| VS3-QX304 | Mouse Anti-CTSD Recombinant Antibody (clone 13F4) | WB, IHC | Mouse IgG2b |
| VS3-XY557 | Mouse Anti-CTSD Recombinant Antibody (clone 3F2C2) | ELISA, WB, IHC | Mouse IgG1 |
Rabbit Monoclonal Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-0867 | Hi-Affi™ Rabbit Anti-CTSD Recombinant Antibody (clone DS867AB) | ICC, IHC-P, WB | Rabbit IgG |
scFv Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0399-CN-S(P) | Human Anti-CTSD Recombinant Antibody; scFv Fragment (HPAB-0399-CN-S(P)) | ELISA, IF, IP, Neut | Human scFv |
| HPAB-0400-CN-S(P) | Human Anti-CTSD Recombinant Antibody; scFv Fragment (HPAB-0400-CN-S(P)) | ELISA, IF, IP, Neut | Human scFv |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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