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    For Research Use Only. Not For Clinical Use.


    Creative Biolabs is your apoptosis research partner, providing top quality anti-CYCS recombinant antibodies. A pivotal electron carrier and the final pro-apoptotic signal, Cytochrome C (CYCS) is the molecule that decides cellular life and death. Our high-performance antibodies are the key reagents to study its role in the electron transport chain and the dramatic release from the mitochondria during intrinsic apoptosis.

    CYCS: The Central Switch for Apoptosis

    Cytochrome C (CYCS) is a small, highly conserved protein. It has two cellular compartments where it functions physiologically and pathologically. Physiologically, CYCS is a mobile electron carrier found in the intermembrane space of the mitochondria that transports electrons from Complex III to Complex IV (Cytochrome c oxidase). Pathologically, it is the primary initiator of the intrinsic apoptosis pathway. In response to pro-apoptotic stimuli, CYCS is released from the mitochondria into the cytosol where it binds Apaf-1, an essential step in the formation of the apoptosome and the activation of Caspase-9. The cell is now committed to die.

    Alternative Names

    CYC; HCS; THC4; cytochrome c; Cytochrome c, somatic

    Background

    CYCS (Cytochrome C, Somatic) is a Protein Coding gene. Diseases associated with CYCS include Thrombocytopenia 4 and Autosomal Thrombocytopenia With Normal Platelets. Among its related pathways are Apoptotic Pathways in Synovial Fibroblasts and Apoptosis Modulation and Signaling. Gene Ontology (GO) annotations related to this gene include iron ion binding and electron transfer activity.

    Protein class

    Disease related genes, Human disease related genes, Plasma proteins

    Predicted location

    Intracellular

    Single cell type specificity

    Cell type enhanced (Distal tubular cells)

    Immune cell specificity

    Low immune cell specificity

    Cell line specificity

    Low cell line specificity

    More Types Infomation

    Anti-CYCS rAb Products

    Creative Biolabs' anti-CYCS recombinant antibodies are the gold standard for apoptosis research. In addition to antibodies that can detect total CYCS, we have antibodies optimized for immunofluorescence and Western Blot that can study its release from the mitochondria to the cytosol – the point of no return of intrinsic apoptosis. Our rAbs offer unsurpassed reliability.

    Table 1. Featured anti-CYCS recombinant antibody products at Creative Biolabs.

    Cat. No. Product Name Target Species Host Species Applications
    ZG-0221J Mouse Anti-CYCS Recombinant Antibody (clone 4B10) Human, Mouse, Rat, Chicken Mouse IgG WB, IF, ICC, IHC-P
    NEUT-698CQ Mouse Anti-CYCS Recombinant Antibody (clone 6H2.B4) Human, Mouse, Rat Mouse IgG1, κ IP, Neut
    FAMAB-0115JF Mouse Anti-CYCS Recombinant Antibody (clone 1G7.A3) Mouse, Pigeon Mouse IgG WB, FC, IHC, IF

    Creative Quality Control

    Creative Biolabs has zero tolerance for scientific failure. Antibody production at Creative Biolabs is supported by a comprehensive quality assurance system. Every lot of antibodies undergoes extensive testing to ensure product purity, specificity, and reliable performance in well-characterized apoptosis induction models.

    Fig.1 IF analysis. (Creative Biolabs Original) Fig.1 IF analysis of anti-CYCS antibody
    (Cat# ZG-0221J, Creative Biolabs).

    Fig.2 IHC analysis. (Creative Biolabs Original) Fig.2 IHC analysis of anti-CYCS antibody
    (Cat# ZG-0221J, Creative Biolabs).

    Customer Reviews

    Excellent
    Jen**a
    Mouse Anti-CYCS Recombinant Antibody (clone 4B10)
    The anti-CYCS antibody from Creative Biolabs was an essential reagent for our apoptosis studies. We were able to clearly detect its release into the cytosol after drug treatment by western blot.
    03/Jan/2024

    rAb Production

    To advance apoptosis research, Creative Biolabs has access to the latest rAb production technologies. Our anti-CYCS recombinant antibodies are crafted with the utmost precision to ensure high-affinity binding and specificity for studying the movement of this crucial protein.

    Featured Anti-CYCS Recombinant Antibody Production PlatformsFig.3 Milligram-scale. (Creative Biolabs Original)
    Fig.3 Milligram-scale anti-CYCS recombinant antibody production.

    Fig.4 Gram-scale. (Creative Biolabs Original)Fig.4 Gram-scale anti-CYCS recombinant antibody production.

    rAb Modalities

    Creative Biolabs is committed to fostering scientific discoveries by providing innovative and flexible antibody solutions. Our portfolio of anti-CYCS antibodies includes a variety of customizable formats to meet the diverse needs of your experiments.

    Fig.5 CYCS antibody production and modalities. (Creative Biolabs Original)Fig.5 Full-length anti-CYCS recombinant antibody production and modalities.

    Probe the details of intrinsic apoptosis with Creative Biolabs' superior anti-CYCS recombinant antibodies. Our portfolio of validated, purpose-built antibodies offers the quality and application specificity you need to study this master regulator of cell fate. Trust our scientific experience to build a solid foundation for your research. Speak with our specialists today.

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