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Target
Application
Host
Type
Species Reactivity
Conjugate
Derivation


DHFR

Anti-DHFR ProductsBackground
Anti-DHFR Products
-
- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG2b
- Application: WB, ICC, IHC
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- Species Reactivity: Human, Mouse, Rat
- Type: Rabbit IgG
- Application: ELISA, WB, IHC, IP
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- Species Reactivity: Human, Mouse, Rat
- Type: Rabbit IgG
- Application: WB, IHC-P, ICC, IF
-
- Species Reactivity: Human
- Application: IHC-P, WB
- Mouse Anti-NHP DHFR Recombinant Antibody (clone OTI6G7) (VS-1024-XY163)
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- Species Reactivity: Dog, Human, Non-human primate
- Type: Mouse IgG1
- Application: WB, IHC, IF
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- Derivation: Llama
- Species Reactivity: E. coli
- Type: Llama VHH
- Application: FACS, ELISA, FuncS
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- Derivation: Llama
- Species Reactivity: E. coli
- Type: Llama VHH
- Application: WB, FuncS
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- Derivation: Llama
- Species Reactivity: E. coli
- Type: Llama VHH
- Application: NMR, ELISA
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- Derivation: Llama
- Species Reactivity: E. coli
- Type: Llama VHH
- Application: WB, FuncS
- Anti-DHFR Immunohistochemistry Kit (VS-0525-XY1984)
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- Species Reactivity: Human
- Target: DHFR
- Application: IHC
- Anti-Mouse DHFR Immunohistochemistry Kit (VS-0525-XY1985)
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- Species Reactivity: Human, Mouse, Rat
- Target: DHFR
- Application: IHC
- Anti-Canine DHFR Immunohistochemistry Kit (VS-0525-XY1986)
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- Species Reactivity: Human, Mouse, Rat, Canine, Monkey
- Target: DHFR
- Application: IHC
-
- Derivation: Phage display library
- Species Reactivity: Human
- Type: Rabbit IgG
- Application: ICC, IF, IHC-P
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More Infomation
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For Research Use Only. Not For Clinical Use.
Background
Dihydrofolate reductase converts dihydrofolate into tetrahydrofolate, a methyl group shuttle required for the de novo synthesis of purines, thymidylic acid, and certain amino acids. While the functional dihydrofolate reductase gene has been mapped to chromosome 5, multiple intronless processed pseudogenes or dihydrofolate reductase-like genes have been identified on separate chromosomes. Dihydrofolate reductase deficiency has been linked to megaloblastic anemia. Several transcript variants encoding different isoforms have been found for this gene.
Protein class
Cancer-related genes, Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Metabolic proteins
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (Erythroid cells, Spermatocytes)
Immune cell specificity
Not detected in immune cells
Cell line specificity
Low cell line specificity
Interaction
Homodimer.
Molecular function
Oxidoreductase, RNA-binding
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