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DHFR

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Dihydrofolate reductase converts dihydrofolate into tetrahydrofolate, a methyl group shuttle required for the de novo synthesis of purines, thymidylic acid, and certain amino acids. While the functional dihydrofolate reductase gene has been mapped to chromosome 5, multiple intronless processed pseudogenes or dihydrofolate reductase-like genes have been identified on separate chromosomes. Dihydrofolate reductase deficiency has been linked to megaloblastic anemia. Several transcript variants encoding different isoforms have been found for this gene.

Derivation:
Llama
Species Reactivity:
E. coli
Type:
Llama VHH
Application:
FACS, ELISA, FuncS
Derivation:
Llama
Species Reactivity:
E. coli
Type:
Llama VHH
Application:
WB, FuncS
Derivation:
Llama
Species Reactivity:
E. coli
Type:
Llama VHH
Application:
NMR, ELISA
Derivation:
Llama
Species Reactivity:
E. coli
Type:
Llama VHH
Application:
WB, FuncS
Species Reactivity:
Human
Application:
IHC-P, WB
Derivation:
Phage display library screening
Species Reactivity:
Human
Type:
IgG
Application:
ICC/IF, IHC-P
Derivation:
Mouse
Species Reactivity:
Human
Type:
IgG
Application:
ELISA, WB, IF, FuncS
Derivation:
Mouse
Species Reactivity:
Human
Type:
Fab
Application:
IP, FuncS
Derivation:
Mouse
Species Reactivity:
Human
Type:
scFv
Application:
WB, Neut, FuncS
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