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EPHA3
This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. This gene encodes a protein that binds ephrin-A ligands. Two alternatively spliced transcript variants have been described for this gene.
Protein class
Cancer-related genes, Disease related genes, Enzymes, Metabolic proteins, Potential drug targets
Predicted location
Intracellular, Membrane (different isoforms)
Single cell type specificity
Group enriched (Inhibitory neurons, Microglial cells, Excitatory neurons, Oligodendrocytes)
Immune cell specificity
Not detected in immune cells
Cell line specificity
Cell line enriched (AF22)
Interaction
Heterotetramer upon binding of the ligand. The heterotetramer is composed of an ephrin dimer and a receptor dimer. Oligomerization is probably required to induce biological responses. Forms a ternary EFNA5-EPHA3-ADAM10 complex mediating EFNA5 extracellular domain shedding by ADAM10 which regulates the EFNA5-EPHA3 complex internalization and function. Interacts with NCK1 (via SH2 domain); mediates EFNA5-EPHA3 signaling (By similarity). Interacts (phosphorylated) with PTPN1; dephosphorylates EPHA3 and may regulate its trafficking and function. Interacts (phosphorylated) with CRK; mediates EFNA5-EPHA3 signaling through RHOA GTPase activation.
Molecular function
Kinase, Receptor, Transferase, Tyrosine-protein kinase
More Types Infomation
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- Derivation: Phage display library
- Species Reactivity: Human
- Type: Rabbit IgG
- Application: WB
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- Anti-Human EPHA3 Recombinant Antibody (KB004) (TAB-237CL)
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- Derivation: Chimeric (human/mouse)
- Species Reactivity: Human
- Type: Antibody
- Application: IHC, WB, IF, FC
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- Human Anti-EPHA3 Antibody, mRNA (Gly-101LC-mRNA)
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- Species Reactivity: Human
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- Derivation: Humanized
- Species Reactivity: Human
- Type: ADCC enhanced antibody
- Application: ELISA, IHC, FC, IP, IF, FuncS
Compare
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- Derivation: Humanized
- Species Reactivity: Human
- Type: ADCC enhanced antibody
- Application: ELISA, IHC, FC, IP, IF, FuncS
Compare
- Human Anti-EPHA3 Recombinant Antibody; scFv Fragment (HPAB-0007-LS-S(P)) (HPAB-0007-LS-S(P))
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- Species Reactivity: Human
- Type: Human scFv
- Application: ELISA, FC
Compare
- Human Anti-EPHA3 Recombinant Antibody; Fab Fragment (HPAB-0007-LS-F(E)) (HPAB-0007-LS-F(E))
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- Species Reactivity: Human
- Type: Human Fab
- Application: ELISA, FC
Compare
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- Derivation: Humanized
- Species Reactivity: Human
- Type: IgG1, κ
- Application: ELISA, IHC, FC, IP, IF, FuncS
Compare
- Rabbit Anti-EPHA3 Recombinant Antibody (VS-0723-WK252) (VS-0723-WK252)
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- Species Reactivity: Human
- Type: Rabbit IgG
- Application: ELISA, FC
Compare
- Human Anti-EPHA3 Recombinant Antibody (HPAB-0007-LS) (HPAB-0007-LS)
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- Species Reactivity: Human
- Type: Human IgG κ
- Application: ELISA, FC
Compare
More Infomation
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For Research Use Only. Not For Clinical Use.