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    FOS

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    For Research Use Only. Not For Clinical Use.


    Background

    The Fos gene family consists of 4 members: FOS, FOSB, FOSL1, and FOSL2. These genes encode leucine zipper proteins that can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1. As such, the FOS proteins have been implicated as regulators of cell proliferation, differentiation, and transformation. In some cases, expression of the FOS gene has also been associated with apoptotic cell death.
    Protein class

    Cancer-related genes, Transcription factors

    Predicted location

    Intracellular

    Single cell type specificity

    Low cell type specificity

    Immune cell specificity

    Immune cell enriched (neutrophil)

    Cell line specificity

    Cell line enhanced (hTCEpi, OE19)

    Interaction

    Heterodimer; with JUN (By similarity). Component of the SMAD3/SMAD4/JUN/FOS complex required for synergistic TGF-beta-mediated transcription at the AP1 promoter site (PubMed:9732876). Interacts with SMAD3; the interaction is weak even on TGF-beta activation (PubMed:9732876). Interacts with MAFB (By similarity). Interacts with DSIPI; this interaction inhibits the binding of active AP1 to its target DNA (By similarity). Interacts with CDS1 and PI4K2A (By similarity). Interacts (via bZIP domain and leucine-zipper region) with the multiprotein chromatin-remodeling complexes SWI/SNF: SWI/SNF-A (BAF) subunits SMARCB1, SMARCC2 and SMARCD1 (By similarity). Interacts (via bZIP domain and leucine-zipper region) with ARID1A (By similarity).

    Molecular function

    DNA-binding

    More Types Infomation
    Related Diseases
    Colorectal Cancer Colorectal Cancer
    Endometrial Cancer Endometrial Cancer
    Gastric Cancer Gastric Cancer
    Non-small Cell Lung Cancer Non-small Cell Lung Cancer
    Insulin Resistance Insulin Resistance
    Related Signaling Pathways
    NLR Signaling Pathway NLR Signaling Pathway
    TNF Signaling Pathway TNF Signaling Pathway
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