+ Filter
Loading...
FOXO3
Loading...Anti-FOXO3 Products
- Rabbit Anti-FOXO3 Recombinant Antibody (clone SP0054) (MRO-0602-CN)
-
- Species Reactivity: Human
- Type: Rabbit IgG
- Application: WB, IF
Compare
- Rabbit Anti-FOXO3 Polyclonal Antibody (MRO-1871-CN) (MRO-1871-CN)
-
- Species Reactivity: Human, Mouse
- Type: Rabbit IgG
- Application: WB, IF, IHC, FC
Compare
-
- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG2a, κ
- Application: WB, ELISA, IF, IHC
Compare
- Recombinant Mouse Anti-Human FOXO3 Antibody (MOB-1068MZ)
-
- Species Reactivity: Human
- Type: Mouse antibody
- Application: IHC-P
Compare
- Anti-FOXO3 Immunohistochemistry Kit (VS-0525-XY2634)
-
- Species Reactivity: Human
- Target: FOXO3
- Application: IHC
Compare
- Anti-Mouse FOXO3 Immunohistochemistry Kit (VS-0525-XY2635)
-
- Species Reactivity: Human, Mouse, Rat
- Target: FOXO3
- Application: IHC
Compare
More Infomation
Can't find the products you're looking for? Try to filter in the left sidebar.Filter By Tag
More Infomation
Our customer service representatives are available 24 hours a day, from Monday to Sunday. Contact Us
For Research Use Only. Not For Clinical Use.
This gene belongs to the forkhead family of transcription factors which are characterized by a distinct forkhead domain. This gene likely functions as a trigger for apoptosis through expression of genes necessary for cell death. Translocation of this gene with the MLL gene is associated with secondary acute leukemia. Alternatively spliced transcript variants encoding the same protein have been observed. [provided by RefSeq, Jul 2008]
Protein class
Cancer-related genes, Disease related genes, Transcription factors
Predicted location
Intracellular
Single cell type specificity
Low cell type specificity
Immune cell specificity
Immune cell enhanced (neutrophil)
Cell line specificity
Cell line enhanced (Karpas-707)
Interaction
Upon metabolic stress, forms a complex composed of FOXO3, SIRT3 and mitochondrial RNA polymerase POLRMT; the complex is recruited to mtDNA in a SIRT3-dependent manner (PubMed:23283301). Also forms a complex composed of FOXO3, SIRT3, TFAM and POLRMT (PubMed:29445193). Interacts with SIRT2; the interaction occurs independently of SIRT2 deacetylase activity (By similarity). Interacts with YWHAB/14-3-3-beta and YWHAZ/14-3-3-zeta, which are required for cytosolic sequestration (PubMed:16751106). Upon oxidative stress, interacts with STK4/MST1, which disrupts interaction with YWHAB/14-3-3-beta and leads to nuclear translocation (PubMed:16751106). Interacts with PIM1 (PubMed:18593906). Interacts with DDIT3/CHOP (PubMed:22761832). Interacts (deacetylated form) with SKP2 (PubMed:21841822). Interacts with CHUK and IKBKB (PubMed:15084260, PubMed:22313691). Interacts with CAMK2A, CAMK2B and calcineurin A (By similarity). Interacts with NUPR1; this interaction represses FOXO3 transactivation (PubMed:20181828).
Molecular function
Activator, DNA-binding
More Types Infomation
Related Diseases
Gastric Cancer
Hepatocellular Carcinoma
Related Signaling Pathways
Insulin Signaling Pathway
mTOR Signaling Pathway
PI3K-Akt Signaling Pathway