FOXO3

Cancer Stem Cell Biomarker Specific Antibody Products Recombinant Antibody Products Formats Research Area

Anti-FOXO3 Recombinant Antibody Products

Rabbit Anti-FOXO3 Recombinant Antibody (clone SP0054) (MRO-0602-CN)
- Species Reactivity: Human
- Type: Rabbit IgG
- Application: WB, IF
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Rabbit Anti-FOXO3 Polyclonal Antibody (MRO-1871-CN) (MRO-1871-CN)
- Species Reactivity: Human, Mouse
- Type: Rabbit IgG
- Application: WB, IF, IHC, FC
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Rabbit Anti-FOXO3 Recombinant Antibody (clone 1E1) (ZG-0675J)
- Species Reactivity: Human
- Type: Rabbit IgG
- Application: ELISA, WB, IHC
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Rabbit Anti-FOXO3 (pS253) Recombinant Antibody (VS3-WK2258) (VS3-WK2258)
- Species Reactivity: Human, Mouse, Rat
- Type: Rabbit IgG
- Application: WB
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Rabbit Anti-FOXO3 Recombinant Antibody (clone 1E2) (ZG-0676J)
- Species Reactivity: Human
- Type: Rabbit IgG
- Application: ELISA, WB, IHC, IF
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Rabbit Anti-FOXO3 Recombinant Antibody (VS3-CJ151) (VS3-CJ151)
- Species Reactivity: Human, Mouse, Rat
- Type: Rabbit IgG
- Application: WB, IHC
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Recombinant Rabbit Anti-FOXO3 Antibody (clone R03-2H2) (VS3-FY560)
- Species Reactivity: Human
- Type: Rabbit IgG
- Application: WB
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Recombinant Rabbit Anti-FOXO3 (phospho Ser253) Antibody (clone R06-2G6) (VS3-FY561)
- Species Reactivity: Human, Mouse, Rat
- Type: Rabbit IgG
- Application: WB
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Rabbit Anti-FOXO3 Recombinant Antibody (clone R09-3J1) (VS3-XY3361)
- Species Reactivity: Human, Mouse, Rat
- Type: Rabbit IgG
- Application: WB, ICC, IF
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Rabbit Anti-FOXO3 (pS235) Recombinant Antibody (clone R08-7U1) (VS3-WK2120)
- Species Reactivity: Human, Mouse, Rat
- Type: Rabbit IgG
- Application: WB, IHC-P
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Mouse Anti-FOXO3 Recombinant Antibody (clone 9G10) (MOB-4019z)
- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG2a, κ
- Application: WB, ELISA, IF, IHC
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Recombinant Mouse Anti-Human FOXO3 Antibody (MOB-1068MZ)
- Species Reactivity: Human
- Type: Mouse antibody
- Application: IHC-P
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Rabbit Anti-FOXO3 Antibody (VS-0924-YC40) - Cancer Stem Cell Marker (VS-0924-YC40)
- Species Reactivity: Human
- Type: Rabbit IgG
- Application: IF
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Hi-Affi™ Rabbit Anti-FOXO3 Recombinant Antibody (clone DS1344AB) (MOR-1344)
- Derivation: Phage display library
- Species Reactivity: Human
- Type: Rabbit IgG
- Application: ICC, IF, IHC-P, WB
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For Research Use Only. Not For Clinical Use.

This gene belongs to the forkhead family of transcription factors which are characterized by a distinct forkhead domain. This gene likely functions as a trigger for apoptosis through expression of genes necessary for cell death. Translocation of this gene with the MLL gene is associated with secondary acute leukemia. Alternatively spliced transcript variants encoding the same protein have been observed. [provided by RefSeq, Jul 2008]

Protein class

Cancer-related genes, Disease related genes, Transcription factors

Predicted location

Intracellular

Single cell type specificity

Low cell type specificity

Immune cell specificity

Immune cell enhanced (neutrophil)

Cell line specificity

Cell line enhanced (Karpas-707)

Interaction

Upon metabolic stress, forms a complex composed of FOXO3, SIRT3 and mitochondrial RNA polymerase POLRMT; the complex is recruited to mtDNA in a SIRT3-dependent manner (PubMed:23283301). Also forms a complex composed of FOXO3, SIRT3, TFAM and POLRMT (PubMed:29445193). Interacts with SIRT2; the interaction occurs independently of SIRT2 deacetylase activity (By similarity). Interacts with YWHAB/14-3-3-beta and YWHAZ/14-3-3-zeta, which are required for cytosolic sequestration (PubMed:16751106). Upon oxidative stress, interacts with STK4/MST1, which disrupts interaction with YWHAB/14-3-3-beta and leads to nuclear translocation (PubMed:16751106). Interacts with PIM1 (PubMed:18593906). Interacts with DDIT3/CHOP (PubMed:22761832). Interacts (deacetylated form) with SKP2 (PubMed:21841822). Interacts with CHUK and IKBKB (PubMed:15084260, PubMed:22313691). Interacts with CAMK2A, CAMK2B and calcineurin A (By similarity). Interacts with NUPR1; this interaction represses FOXO3 transactivation (PubMed:20181828).

Molecular function

Activator, DNA-binding

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