Rabbit Anti-FOXO3 Recombinant Antibody (clone R09-3J1)
CAT#: VS3-XY3361
The rabbit recombinant antibody specifically recognizes FOXO3 (Forkhead box O3), which triggers apoptosis in the absence of survival factors, including neuronal cell death upon oxidative stress. It reacts with human, mouse and rat FOXO3. It has been detected using Western Blot, Immunocytochemistry or Immunofluorescence. The recommended dilutions of Western Blot and Immunofluorescence is 1/500-1/1000 and 1/50-1/200, respectively.








Specifications
- Host Species
- Rabbit
- Type
- Rabbit IgG
- Specificity
- Human, Mouse and Rat FOXO3
- Species Reactivity
- Human, Mouse, Rat
- Clone
- R09-3J1
- Applications
- WB, ICC, IF
- Related Disease
- Rhabdomyosarcoma
Product Property
- Clonality
- Monoclonal
- Aggregation
- < 5%
- Format
- Liquid
- Buffer
- PBS (pH 7.4), 150 mM NaCl and 50% glycerol
- Preservative
- 0.02% sodium azide
- Storage
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- WB: 1/500-1/1000
IF: 1/50-1/200
Target
- Alternative Names
- FOXO2; AF6q21; FKHRL1; FOXO3A; FKHRL1P2
- Gene ID
- 2309
- UniProt ID
- O43524
- Long Name
- Forkhead box O3
- Cellular Localization
- Cytoplasm, Membrane, Mitochondrion, Mitochondrion outer membrane, Nucleus
- Post Translation Modifications
- The N-terminus is cleaved following import into the mitochondrion. (O43524-FOXO3_HUMAN)
Glycosylation at Asn431 (NX_O43524 [NX_O43524-1])
Modification sites at PhosphoSitePlus (O43524)
Glycosylation from GlyConnect FOXO3_HUMAN (1253)
Glycosylation from GlyGen (O43524) 10 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (9 sites)
- Protein Refseq
- XP_016866074.1; XP_016866075.1
- Function
- Acts as a positive regulator of autophagy in skeletal muscle: in starved cells, enters the nucleus following dephosphorylation and binds the promoters of autophagy genes, such as GABARAP1L, MAP1LC3B and ATG12, thereby activating their expression, resulting in proteolysis of skeletal muscle proteins (By similarity).
Triggers apoptosis in the absence of survival factors, including neuronal cell death upon oxidative stress (PubMed:10102273, 16751106).
Participates in post-transcriptional regulation of MYC: following phosphorylation by MAPKAPK5, promotes induction of miR-34b and miR-34c expression, 2 post-transcriptional regulators of MYC that bind to the 3'UTR of MYC transcript and prevent its translation.
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Related Diseases
Related Signaling Pathways
Downloadable Resources
Download resources about recombinant antibody development and antibody engineering to boost your research.
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Protocol & Troubleshooting
We have outlined the assay protocols, covering reagents, solutions, procedures, and troubleshooting tips for common issues in order to better assist clients in conducting experiments with our products. View the full list of Protocol & Troubleshooting.
Isotype Control
- CAT
- Product Name
Recommended Dilution Buffer
- CAT
- Product Name
Secondary Antibody
- CAT
- Product Name
See other products for "FOXO3"
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MOB-4019z | Mouse Anti-FOXO3 Recombinant Antibody (clone 9G10) | WB, ELISA, IF, IHC | Mouse IgG2a, κ |
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CAT | Product Name | Application | Type |
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MOR-1344 | Hi-Affi™ Rabbit Anti-FOXO3 Recombinant Antibody (clone DS1344AB) | ICC, IF, IHC-P, WB | Rabbit IgG |
CAT | Product Name | Application | Type |
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VS-0924-YC40 | Rabbit Anti-FOXO3 Antibody (VS-0924-YC40) - Cancer Stem Cell Marker | IF | Rabbit IgG |
CAT | Product Name | Application | Type |
---|---|---|---|
VS-0525-XY2634 | Anti-FOXO3 Immunohistochemistry Kit | IHC | |
VS-0525-XY2635 | Anti-Mouse FOXO3 Immunohistochemistry Kit | IHC | |
VS-0525-XY2636 | Anti-Rat FOXO3 Immunohistochemistry Kit | IHC |
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