Anti-HSPA8 Recombinant Antibody Products

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Anti-HSPA8 Products

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For Research Use Only. Not For Clinical Use.

To advance your research into selective protein degradation and lysosomal biology, Creative Biolabs provides premium anti-HSPA8 recombinant antibodies. This constitutive molecular chaperone is the central mediator of chaperone-mediated autophagy (CMA), influencing cellular proteostasis throughout the lifespan. Our rich variety of high-quality antibodies ensures that your lab is equipped with the sensitivity needed to investigate autophagy efficiency and its role in age-related neurodegeneration.

HSPA8: Potential target in Aging, Alzheimer's Disease, and Lysosomal Storage Disorders

HSPA8, or Hsc70, is a member of the Hsp70 family expressed at high levels under normal conditions. It is the central player in CMA, where it recognizes proteins with a specific motif and delivers them to the lysosome for degradation. CMA activity naturally declines with age, contributing to toxic aggregates in neurodegenerative diseases. Furthermore, HSPA8 is involved in clathrin-mediated endocytosis and the uncoating of coated vesicles. Understanding the regulation of HSPA8 activity is therefore necessary for developing therapies that restore cellular clearance pathways. Robust antibody tools are required to detect HSPA8 in various cellular compartments.

Alternative Names

LAP1; HSC54; HSC70; HSC71; HSP71; HSP73; LAP-1; NIP71; HEL-33; HSPA10; HEL-S-72p; heat shock cognate 71 kDa protein; LPS-associated protein 1; N-myristoyltransferase inhibitor protein 71; constitutive heat shock protein 70; epididymis luminal protein 33; epididymis secretory sperm binding protein Li 72p; heat shock 70kDa protein 8; heat shock 70kd protein 10; heat shock cognate protein 54; lipopolysaccharide-associated protein 1

Background

This gene encodes a member of the heat shock protein 70 family, which contains both heat-inducible and constitutively expressed members. This protein belongs to the latter group, which are also referred to as heat-shock cognate proteins. It functions as a chaperone, and binds to nascent polypeptides to facilitate correct folding. It also functions as an ATPase in the disassembly of clathrin-coated vesicles during transport of membrane components through the cell. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Anti-HSPA8 rAb Products

Engineered for maximum molecular precision, our anti-HSPA8 recombinant antibodies deliver exceptional affinity for the Hsc70 protein. These antibodies allow for the accurate detection of HSPA8 in diverse cellular fractions, providing researchers with a credible tool for quantifying CMA activity and studying the molecular mechanisms of lysosomal protein delivery with absolute confidence.

Table 1. Featured anti-HSPA8 recombinant antibody products at Creative Biolabs.

Creative Quality Control

The anti-HSPA8 antibodies provided by Creative Biolabs use the most optimized pipeline in the production process and strictly control the quality to ensure the performance and reliability of the antibody products. The applications focus on WB and ELISA. Meticulous quality checks ensure high signal clarity and consistent quantification, meeting the strict requirements of autophagy and cell biology research.

Customer Reviews

Excellent

El**a
Mouse Anti-HSPA8 Recombinant Antibody (clone 2G8F6)

The anti-HSPA8 antibody from Creative Biolabs was instrumental in our CMA study. The specificity in Western Blot allowed us to clearly distinguish Hsc70 from inducible Hsp70.

28/Nov/2024

rAb Production

We express antibodies through eukaryotic and prokaryotic expression systems and ensure the high quality of antibodies through excellent production processes. This multi-platform approach allows us to refine manufacturing, ensuring that each anti-HSPA8 recombinant antibody meets the highest standards for performance in clearance studies.

Featured Anti-HSPA8 Recombinant Antibody Production Platforms
Fig.3 Milligram-scale anti-HSPA8 recombinant antibody production.

Fig.4 Gram-scale anti-HSPA8 recombinant antibody production.

rAb Modalities

Creative Biolabs provides high-quality, customizable anti-HSPA8 recombinant antibodies to meet specific research needs. These antibodies are available in a variety of formats and are carefully tailored to meet the specific needs of the local, national, and global research community.

Fig.5 Full-length anti-HSPA8 recombinant antibody production and modalities.

HSPA8-Targeted Drug Information

Table 2. Public drug targeting HSPA8.

(Disclaimer: The information in this table is just for knowledge sharing and not for marketing or sales purposes.)

Creative Biolabs provides high-quality antibodies against HSPA8 and encourages customers to contact us for more information. Our specialized HSPA8 antibodies are designed to support your breakthroughs in autophagy and protein trafficking research. Contact our scientific team today.