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IL12B

Engineered Antibody
This gene encodes the beta subunit p40 of the Interleukin 12 (IL-12) family of cytokines. Members of the IL-12 family form heterodimers consisting of heavy and light subunits linked by disulfide bonds. The product of this gene, p40, is a subunit of interleukins IL-12 and IL-23.
Protein class

Disease related genes, FDA approved drug targets, Human disease related genes, Plasma proteins

Predicted location

Secreted

Single cell type specificity

Cell type enriched (monocytes)

Immune cell specificity

Not detected in immune cells

Cell line specificity

Cell line enhanced (SCLC-21H)

Interaction

Heterodimer with IL12A; disulfide-linked. The heterodimer is known as interleukin IL-12. Heterodimer with IL23A; disulfide-linked. The heterodimer is known as interleukin IL-23. Also secreted as a monomer.

Molecular function

Cytokine

More Types Infomation
Related Diseases
Inflammatory Bowel Diseases Inflammatory Bowel Diseases
Allograft Rejection Allograft Rejection
Autoimmune Thyroid Disease Autoimmune Thyroid Disease

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