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Anti-IL6R Recombinant Antibody Products

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Anti-IL6R Products

  • IL6-DT immunotoxin (AGTO-L080D)
    • Species Reactivity: Human
    • Application: Cytotoxicity assay, Functional assay
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  • IL6-PE immunotoxin (AGTO-L080E)
    • Species Reactivity: Human
    • Application: Cytotoxicity assay, Functional assay
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For Research Use Only. Not For Clinical Use.


Creative Biolabs provides highly grade anti-IL6R recombinant antibodies with exact engineering in the field of targeted cancer therapy research and development. These antibodies are produced to reach the best performance. By means of modern platforms, these antibodies show remarkable specificity, stability, and efficacy, which in turn helps scientists to create new therapeutic strategies.

IL6R: A Critical Target for Cancer Therapy

The interleukin 6 receptor (IL6R) plays an important role in the etiology of many illnesses, especially those involving chronic inflammation and immunological dysregulation. IL6R's dual membrane-bound and soluble forms enable IL-6 signaling by means of classical and trans-signaling, therefore promoting chronic inflammation and immunological dysregulation in diseases such as rheumatoid arthritis and juvenile idiopathic arthritis, where it drives tissue destruction. It also accelerates the cancer development in multiple myeloma and prostate cancer. Furthermore, linked to increased risk of cardiovascular disease are mutations in IL6R genes, which underlines their crucial role in many different diseases and qualifies as a therapeutic target.

Alternative Names

Interleukin-6 receptor; CD126; cluster of differentiation 126; IL6RA; IL-6RA, IL-6R-1; IL6Q; IL6RQ; gp80; interleukin 6 receptor.

Background

This gene encodes a subunit of the interleukin 6 (IL6) receptor complex. Interleukin 6 is a potent pleiotropic cytokine that regulates cell growth and differentiation and plays an important role in the immune response. The IL6 receptor is a protein complex consisting of this protein and interleukin 6 signal transducer (IL6ST/GP130/IL6-beta), a receptor subunit also shared by many other cytokines. Dysregulated production of IL6 and this receptor are implicated in the pathogenesis of many diseases, such as multiple myeloma, autoimmune diseases, and prostate cancer. Alternatively, spliced transcript variants encoding distinct isoforms have been reported. A pseudogene of this gene is found on chromosome 9.

Anti-IL6R rAb Products

Creative Biolabs provides a set of recombinant anti-IL6R antibodies that are engineered to exhibit excellent specificity and affinity. These antibodies are accessible in a variety of formats to accommodate a broad spectrum of therapeutic and research applications. Using a cutting-edge platform, we enable the effective development of creative IL6R-targeted medicines as well as provide researchers and developers with better tools to hasten discoveries in immunology, cancer biology, and allied fields.

Table 1. Featured anti-IL6R recombinant antibody products at Creative Biolabs.

Cat. No. Product Name Target Species Host Species Applications
TAB-026 Anti-Human IL6R Recombinant Antibody (TAB-026) Human, Cynomolgus Human IgG1, kappa ELISA, FC, IP, FuncS, IF, Neut, ICC
HPAB-AP718-YC-S(P) Human Anti-IL6R Recombinant Antibody (clone A7); scFv Fragment Human Human scFv ELISA, Inhib, FuncS
HPAB-AP721-YC-F(E) Human Anti-IL6R Recombinant Antibody (clone F2); Fab Fragment Human Human Fab ELISA, Inhib, FuncS
AFC-TAB-032ML Afuco™ Anti-IL6R ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-032ML) Human Human ADCC enhanced antibody ELISA, IHC, FC, IP, IF, FuncS
TAB-032ML Anti-Human IL6R Recombinant Antibody (TAB-032ML) Human Human IgG2, κ ELISA, IHC, IF, IP, FC, FuncS

Creative Quality Control

Creative Biolabs keeps tight quality control for anti-IL6R recombinant antibody production. By means of extensive testing and validation, we guarantee that these antibodies exhibit extraordinary specificity, great binding affinity, and other optical characteristics over a broad spectrum of research uses.

Fig.1 ELISA analysis. (Creative Biolabs Original)Fig.1 ELISA analysis of anti-IL6R antibody
(Cat# TAB-026, Creative Biolabs).

Fig.2 WB analysis. (Creative Biolabs Original)Fig.2 WB analysis of anti-IL6R antibody
(Cat# TAB-026, Creative Biolabs).

Fig.3 WB analysis. (Creative Biolabs Original)Fig.3 WB analysis of anti-IL6R antibody
(Cat# AFC-TAB-032ML, Creative Biolabs).

Fig.4 DB analysis. (Creative Biolabs Original)Fig.4 DB analysis of anti-IL6R antibody
(Cat# AFC-TAB-032ML, Creative Biolabs).

Fig.5 ELISA analysis. (Creative Biolabs Original)Fig.5 ELISA analysis of anti-IL6R antibody
(Cat# AFC-TAB-032ML, Creative Biolabs).

Customer Reviews

Excellent
Ku***y
Anti-Human IL6R Recombinant Antibody (TAB-026) (TAB-026)
We recently employed Creative Biolabs' Anti-Human IL6R Recombinant Antibody in an IP experiment, and I'm really pleased with the findings. The antibody showed remarkable specificity, detecting IL6R with a very clear signal and negligible background. We were able to validate our protein interactions with certainty. The constancy and dependability of this antibody have greatly simplified our research. I highly suggest it for anyone looking for an effective anti-IL6R antibody for IP!
12/Feb/2023
Excellent
Wa***u
Mouse Anti-IL6R Recombinant Antibody (HPAB-0449-WJ) (HPAB-0449-WJ)
We're really happy with the outcomes of our ELISA tests using the Anti-Human IL6R Recombinant Antibody from Creative Biolabs. The antibody was highly specific and produced a strong signal, enabling precise and consistent IL6R measurement. The uniformity across batches was outstanding, and the technical support team was really helpful in answering our queries. We found a minimal background, which was critical for our sensitive experiments.
12/Nov/2023
Excellent
Sh***n
Mouse Anti-IL6R Recombinant Antibody (HPAB-0612-WJ) (HPAB-0612-WJ)
We were quite pleased with the outcomes of our most recent flow cytometry (FC) tests using CBL's IL6R antibodies. The antibody's remarkable specificity allowed it to easily differentiate between IL6R-positive cells and the negative controls. We received clear and trustworthy data because of the outstanding signal-to-noise ratio. We also enjoyed the consistency in performance over numerous studies. Creative Biolabs provided clear product documentation and good customer service, making the entire process easy and quick.
29/May/2024

rAb Production

Creative Biolabs offers a consistent supply of exceptional anti-IL6R antibodies that are manufactured by applying state-of-the-art genetic technologies.

Featured Anti-IL6R Recombinant Antibody Production PlatformsFig.6 Milligram-scale. (Creative Biolabs Original)
Fig.6 Milligram-scale anti-IL6R recombinant antibody production.

Fig.7 Gram-scale. (Creative Biolabs Original)Fig.7 Gram-scale anti-IL6R recombinant antibody production.

rAb Modalities

Creative Biolabs offers a comprehensive selection of high-quality anti-IL6R recombinant antibodies in a variety of forms to address the unique needs of global researchers.

Fig.8 IL6R antibody production and modalities. (Creative Biolabs Original)Fig.8 Full-length anti-IL6R recombinant antibody production and modalities.

IL6R-Targeted Drug Information

Table 2. Public drug targeting IL6R.

Research phase Classification Condition Company
Launched - 2023 Follow-on Products
Humanized Monoclonal Antibodies
Arthritis, juvenile idiopathic
Autoimmune disease
Cytokine release syndrome
Giant cell arteritis
Immunological Disorders
Immunosuppression
Juvenile arthritis, polyarticular
Rheumatoid arthritis
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection (COVID-19)
Fresenius Kabi
Merck KGaA (Originator)
Launched - 2020 Human Monoclonal Antibodies Rheumatoid arthritis
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection (COVID-19)
Unidentified condition
Biocad (Originator)
Launched - 2020 Humanized Monoclonal Antibodies Duchenne muscular dystrophy
Human autoimmune encephalitis (HAE)
MOG antibody-associated diseases
Myasthenia gravis
Neuromyelitis optica
Rheumatoid arthritis
Thyroid-associated ophthalmopathy (Graves ophthalmopathy)
Chugai Pharmaceutical (Originator)
Genentech
Roche
Launched - 2017 Cancer Immunotherapy
Human Monoclonal Antibodies
Arthritis, juvenile idiopathic
Axial spondyloarthritis, radiographic (Ankylosing spondylitis)
Cancer
Giant cell arteritis
Juvenile arthritis, polyarticular
Localized scleroderma
Polymyalgia rheumatica
Rheumatoid arthritis
Sarcoidosis
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection (COVID-19)
Systemic mastocytosis
Uveitis
Asahi Kasei Pharma
Regeneron (Originator)
Sanofi (Originator)
sanofi-aventis (Sanofi)
Launched - 2005 Cancer Immunotherapy
Humanized Monoclonal Antibodies
Adult onset Still disease
Amyotrophic lateral sclerosis
Arthritis, juvenile idiopathic
Axial spondyloarthritis, radiographic (Ankylosing spondylitis)
B-cell chronic lymphocytic leukemia
Behcet's disease
Cancer, pancreas
Cancer therapy-associated disorders
Castleman disease
Crohn's disease
Cytokine release syndrome
Diabetes type 1
Edema, macular
Epilepsy, status epilepticus
Familial Mediterranean fever
Giant cell arteritis
Graft-versus-host disease
Hemophagocytic lymphohistiocytosis
Hypertension, pulmonary arterial
Interstitial lung diseases
Juvenile arthritis, polyarticular
Kaposi sarcoma
Major depression
Multiple myeloma
Myocardial infarction
Myositis
Neuromyelitis optica
Osteoarthritis, hand
Polymyalgia rheumatica
Rheumatoid arthritis
Schizophrenia
Schnitzler syndrome
Scleroderma
Scleroderma, systemic (Sclerosis, systemic)
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection (COVID-19)
Sjogren syndrome
Systemic lupus erythematosus
Takayasu's arteritis
Transplant rejection
Transplant rejection, kidney
Vasculitis
Brigham and Women's Hospital
Cedars-Sinai Medical Center
Children's Hospital of Philadelphia
Chugai (Chugai Pharmaceutical)
Chugai Pharmaceutica (Chugai Pharmaceutical)
Chugai Pharmaceutical (Originator)
Genentech (Originator)
Medical College of Wisconsin
National Cancer Institute (NCI) (National Cancer Institute)
National Institute Allergy Infect Dis
Oslo Universitetssykehus
Roche (Originator)
University of Pennsylvania
Registered - 2023 Follow-on Products
Humanized Monoclonal Antibodies
Arthritis, juvenile idiopathic
Rheumatoid arthritis
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection (COVID-19)
Biogen
Bio-Thera Solutions (Originator)
Pre-Registered Cancer Immunotherapy
Follow-on Products
Humanized Monoclonal Antibodies
Inflammatory disorders
Rheumatoid arthritis
Celltrion (Originator)
Phase III Cancer Immunotherapy
Follow-on Products
Humanized Monoclonal Antibodies
Rheumatoid arthritis Generium (Originator)
Phase III Crohn's disease
Thrombocytopenia, immune (Purpura, idiopathic thrombocytopenic)
Ulcerative colitis
InKine (Salix)
Salix (Originator)
Phase III Cancer Immunotherapy
IL-6
Polypeptides, from 41 AA
Recombinant proteins
Anemia
Cancer
Stroke
Pfizer (Originator)

(Disclaimer: The information in this table is just for knowledge sharing and not for marketing or sales purposes.)

If you have any queries about our anti-IL6R recombinant antibody products, please do not hesitate to contact us.

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