Human Anti-IL6R scFv-Fc Chimera (VS-0325-FY12)
CAT#: VS-0325-FY12
The anti-IL6R scFv-Fc antibody is designed to specifically target the IL-6 receptor, a key player in inflammatory and autoimmune responses. It neutralizes IL-6 signaling, making it a potential therapeutic agent for conditions like rheumatoid arthritis and cytokine release syndrome. This antibody format combines the specificity of scFv with the extended half-life provided by the Fc region, enhancing its therapeutic efficacy.

Specifications
- Host Species
- Human
- Type
- Human IgG1, scFv-Fc
- Specificity
- Human IL6R
- Species Reactivity
- Human
- Applications
- ELISA, Flow Cytometry
- Related Disease
- Autoimmune disease
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Target
- Alternative Names
- Interleukin 6 Receptor
- Gene ID
- 3570
- UniProt ID
- P08887
- Long Name
- Interleukin 6 Receptor
- Sequence Similarities
- Belongs to the type I cytokine receptor family. Type 3 subfamily.
- Cellular Localization
- Secreted
- Post Translation Modifications
- A short soluble form is released from the membrane by proteolysis.
The sIL6R is formed mostly by limited proteolysis of membrane-bound receptors, a process referred to as ectodomain shedding, but is also directly secreted from the cells after alternative mRNA splicing.
mIL6R is cleaved by the proteases ADAM10 and ADAM17.
Glycosylated.
Glycosylation is dispensable for transport, signaling, and cell-surface turnover.
Glycosylation at Asn-55 is a protease-regulatory exosite.
Glycosylation is required for ADAM17-mediated proteolysis.
Glycosylation at Asn55, Asn93, Asn221, Asn245, Asn350, and Thr352
Modification sites at PhosphoSitePlus
Glycosylation from GlyGen 9 sites, 4 O-linked glycans (3 sites)
- Protein Refseq
- XP_005245196.1; XP_016856688.1; XP_047275604.1; XP_047275605.1; XP_047275606.1
- Function
- Activation leads to the regulation of the immune response, acute-phase reactions and hematopoiesis (PubMed:30995492, 31235509).
The interaction with membrane-bound IL6R and IL6ST stimulates 'classic signaling', the restricted expression of the IL6R limits classic IL6 signaling to only a few tissues such as the liver and some cells of the immune system.
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Downloadable Resources
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Isotype Control
- CAT
- Product Name
Secondary Antibody
- CAT
- Product Name
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CAT | Product Name | Application | Type |
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CAT | Product Name | Application | Type |
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TAB-690LC | Anti-human IL6R Recombinant Antibody (PM-1) (TAB-690LC) | ELISA | |
TAB-694LC | Rabbit Anti-IL6R Recombinant Antibody (TAB-694LC) | ELISA | Rabbit IgG |
TAB-690LC-F(E) | Anti-human IL6R Fab Fragment (PM-1) | ELISA | |
TAB-694LC-F(E) | Rabbit Anti-IL6R Recombinant Antibody; Fab Fragment (TAB-694LC-F(E)) | ELISA | Rabbit Fab |
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CAT | Product Name | Application | Type |
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TAB-691LC-S(P) | Human Anti-IL6R Recombinant Antibody; scFv Fragment (TAB-691LC-S(P)) | ELISA | Humanized scFv |
TAB-692LC-S(P) | Anti-human IL6R scFv Fragment (TAB-692LC-S(P)) | ELISA | Humanized antibody |
TAB-696LC-S(P) | Human Anti-IL6R Recombinant Antibody; scFv Fragment (TAB-696LC-S(P)) | ELISA | Humanized scFv |
TAB-697LC-S(P) | Human Anti-IL6R Recombinant Antibody; scFv Fragment (TAB-697LC-S(P)) | ELISA | Humanized scFv |
TAB-691LC-F(E) | Human Anti-IL6R Recombinant Antibody; Fab Fragment (TAB-691LC-F(E)) | ELISA | Humanized Fab |
CAT | Product Name | Application | Type |
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NEUT-1485CQ | Mouse Anti-IL6R Recombinant Antibody (clone CBL212) | FC, ELISA, Neut | Mouse IgG1, κ |
NEUT-1486CQ | Mouse Anti-IL6R Recombinant Antibody (clone CBL261) | FC, Neut | Mouse IgG1 |
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CAT | Product Name | Application | Type |
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CAT | Product Name | Application | Type |
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HPAB-0034-WJ-S(P) | Mouse Anti-IL6R Recombinant Antibody (clone 8C1D8B5); scFv Fragment | ELISA, WB | Mouse scFv |
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CAT | Product Name | Application | Type |
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CAT | Product Name | Application | Type |
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HPAB-0446-WJ-F(E) | Mouse Anti-IL6R Recombinant Antibody; Fab Fragment (HPAB-0446-WJ-F(E)) | ELISA | Mouse Fab |
HPAB-AP718-YC-F(E) | Human Anti-IL6R Recombinant Antibody (clone A7); Fab Fragment | ELISA, Inhib, FuncS | Human Fab |
HPAB-AP719-YC-F(E) | Human Anti-IL6R Recombinant Antibody (clone B10); Fab Fragment | ELISA | Human Fab |
HPAB-AP720-YC-F(E) | Human Anti-IL6R Recombinant Antibody (clone D2); Fab Fragment | ELISA | Human Fab |
HPAB-AP721-YC-F(E) | Human Anti-IL6R Recombinant Antibody (clone F2); Fab Fragment | ELISA, Inhib, FuncS | Human Fab |
CAT | Product Name | Application | Type |
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CAT | Product Name | Application | Type |
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CAT | Product Name | Application | Type |
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