Human Anti-IL6R scFv-Fc Chimera (VS-0325-FY12)

CAT#: VS-0325-FY12

The anti-IL6R scFv-Fc antibody is designed to specifically target the IL-6 receptor, a key player in inflammatory and autoimmune responses. It neutralizes IL-6 signaling, making it a potential therapeutic agent for conditions like rheumatoid arthritis and cytokine release syndrome. This antibody format combines the specificity of scFv with the extended half-life provided by the Fc region, enhancing its therapeutic efficacy.

Gene Expression
Figure 1 RNA cell line category: Cell line enhanced (THP-1, U-266/84)

Specifications

  • Host Species
  • Human
  • Type
  • Human IgG1, scFv-Fc
  • Specificity
  • Human IL6R
  • Species Reactivity
  • Human
  • Applications
  • ELISA, Flow Cytometry
  • Related Disease
  • Autoimmune disease

Product Property

  • Purity
  • >95% as determined by SDS-PAGE
  • Concentration
  • Please refer to the vial label for the specific concentration.
  • Storage
  • Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
  • Shipping
  • Ice packs

Target

  • Alternative Names
  • Interleukin 6 Receptor
  • Long Name
  • Interleukin 6 Receptor
  • Sequence Similarities
  • Belongs to the type I cytokine receptor family. Type 3 subfamily.
  • Cellular Localization
  • Secreted
  • Post Translation Modifications
  • A short soluble form is released from the membrane by proteolysis.
    The sIL6R is formed mostly by limited proteolysis of membrane-bound receptors, a process referred to as ectodomain shedding, but is also directly secreted from the cells after alternative mRNA splicing.
    mIL6R is cleaved by the proteases ADAM10 and ADAM17.
    Glycosylated.
    Glycosylation is dispensable for transport, signaling, and cell-surface turnover.
    Glycosylation at Asn-55 is a protease-regulatory exosite.
    Glycosylation is required for ADAM17-mediated proteolysis.
    Glycosylation at Asn55, Asn93, Asn221, Asn245, Asn350, and Thr352
    Modification sites at PhosphoSitePlus
    Glycosylation from GlyGen 9 sites, 4 O-linked glycans (3 sites)
  • Function
  • Activation leads to the regulation of the immune response, acute-phase reactions and hematopoiesis (PubMed:30995492, 31235509).
    The interaction with membrane-bound IL6R and IL6ST stimulates 'classic signaling', the restricted expression of the IL6R limits classic IL6 signaling to only a few tissues such as the liver and some cells of the immune system.
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Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Datasheet

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COA

Certificate of Analysis Lookup

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Secondary Antibody

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