AbPlus™ Anti-IL6R Magnetic Beads (B-R6)

Name: AbPlus™ Anti-IL6R Magnetic Beads (B-R6)
SKU: VS-0424-XY152
Rating: 5 (1 reviews)

CAT#: VS-0424-XY152

The AbPlus Anti-IL6R Magnetic Beads (B-R6) is an innovative affinity resin which is bound with anti-IL6R specific antibody (B-R6). The beads were designed for small-scale affinity purification and immunoprecipitation (IP) of IL6R protein under native and denaturing conditions.

Gene Expression

RNA Expression Figure 1 RNA cell line category: Cell line enhanced (THP-1, U-266/84)

Cell lines ordered by descending RNA expression order.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000160712-IL6R

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Specifications

Applications
Immunoprecipitation, Protein Purification

Matrix
Magrose bead (> 50 μmol/mL gel)

Bead Ligand
Anti-IL6R specific antibody (B-R6)

Target
IL6R

Immunogen
IL6R (gp80) expressed in CHO cell line

Target Species
Human

Antibody Clone
B-R6

Bead Capacity
20-30 mg/mL binding antibody

Bead size
10-37 μm

Stability
pH 2-14

Format
20% Suspension

Buffer
PBS, pH 7.4, with 1% BSA

Preservative
0.03% Proclin 300

Storage
Stored at 4°C, and is stable for up to 2 years. Do not centrifuge, dry or freeze the magnetic beads.

Applications

Application Notes
The beads are in suspension and will settle upon storage. Prior to use, mix the vial gently (do not vortex) to ensure delivery of proper bead volume.

Target

Introduction
This gene encodes a subunit of the interleukin 6 (IL6) receptor complex. Interleukin 6 is a potent pleiotropic cytokine that regulates cell growth and differentiation and plays an important role in the immune response. The IL6 receptor is a protein complex consisting of this protein and interleukin 6 signal transducer (IL6ST/GP130/IL6-beta), a receptor subunit also shared by many other cytokines. Dysregulated production of IL6 and this receptor are implicated in the pathogenesis of many diseases, such as multiple myeloma, autoimmune diseases and prostate cancer. Alternatively spliced transcript variants encoding distinct isoforms have been reported. A pseudogene of this gene is found on chromosome 9.

Alternative Names
IL6R; interleukin 6 receptor; IL6Q; gp80; CD126; IL6RA; IL6RQ; IL-6RA; IL-6R-1; interleukin-6 receptor subunit alpha; IL-6R 1; CD126 antigen; membrane glycoprotein 80; IL-6 receptor subunit alpha

Gene ID
3570

UniProt ID
P08887

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Downloadable Resources

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Datasheet

Datasheet - VS-0424-XY152.pdf

MSDS

MSDS - VS-0424-XY152.pdf

COA

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