What species is this antibody reactive to?

This antibody specifically reacts with human IL6R, ensuring focused application in related studies. Its precise reactivity allows scientists to achieve comprehensive detection and understanding of human IL6R functions within various biological research settings.

Is it effective in binding IL6R?

Yes, the Anti-IL6R Antibody (TAB-026) is remarkably effective in binding IL6R. It is characterized by its high binding affinity, which enhances the accuracy of research data and contributes to deeper understanding of IL6R's role in cytokine signaling pathways and immune response.

Anti-Human IL6R Recombinant Antibody (TAB-026)

CAT#: TAB-026

Recombinant monoclonal antibody to Human IL6R. It is an immunosuppressive drug, mainly for the treatment of rheumatoid arthritis (RA) and systemic juvenile idiopathic arthritis, a severe form of RA in children. It is a humanized monoclonal antibody against the interleukin-6 receptor (IL-6R). Interleukin 6 (IL-6) is a cytokine that plays an important role in immune response and is implicated in the pathogenesis of many diseases, such as autoimmune diseases, multiple myeloma and prostate cancer.

Tested Data Gene Expression

ELISA

Figure 1 Anti-Human IL6R Antibody (TAB-026) in ELISA

ELISA analysis of TAB-026 was performed by coating with Recombinant Human IL6R Protein.

Figure 2 Anti-Human IL6R Antibody (TAB-026) in WB

Western blot analysis of TAB-026 was performed with Recombinant Human IL6R Protein.
Lane 1: Non-Reducing Antigen (1 μg)
Lane 2: Reducing Antigen (1 μg)

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RNA Expression Figure 1 RNA cell line category: Cell line enhanced (THP-1, U-266/84)

Cell lines ordered by descending RNA expression order.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000160712-IL6R

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Specifications

Immunogen
IL-6R bound to Sepharose4B.

Host Species
Human

Derivation
Humanized (from mouse)

Type
IgG1, kappa

Specificity
Tested positive against native human antigen

Species Reactivity
Human, Cynomolgus

Applications
ELISA, FC, IP, FuncS, IF, Neut, ICC

MW
145.0 kDa

Related Disease
Cytokine Release Syndrome (CRS), Systemic Juvenile Idiopathic Arthritis (sJIA), Giant Cell Arteritis (GCA), and Rheumatoid Arthritis (RA)

Product Property

Purification
Protein A purified

Purity
>95.0% as determined by analysis by SDS-PAGE.

Storage
Store the antibody (in aliquots) at -20°C. Avoid repeated freezing and thawing of samples.

Applications

Application Notes
The IL6R antibody has been reported in applications of Inhibition.

Target

Alternative Names
Interleukin 6 Receptor

Gene ID
3570

UniProt ID
P08887

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Breast cancer biomarkers at key points during disease progression

Excellent Reactivity

The Anti-IL6R Antibody (TAB-026) performs exceptionally in detecting IL6R, supporting an array of research investigations. It stands out for its high binding affinity, contributing to reliable data in experiments. This antibody's consistency across tests has been a key asset for scientists studying the complex IL6R pathways.

Consistent Performance

This antibody provides consistent results, making it a preferred choice for researchers involved in IL6R studies. Its proficiency in delivering accurate outcomes across various assays ensures solid evidence and insights, paving the way for clearer comprehension of the IL6 pathophysiological processes involved in research.

Q&As

What species is this antibody reactive to?

A: This antibody specifically reacts with human IL6R, ensuring focused application in related studies. Its precise reactivity allows scientists to achieve comprehensive detection and understanding of human IL6R functions within various biological research settings.
Is it effective in binding IL6R?

A: Yes, the Anti-IL6R Antibody (TAB-026) is remarkably effective in binding IL6R. It is characterized by its high binding affinity, which enhances the accuracy of research data and contributes to deeper understanding of IL6R's role in cytokine signaling pathways and immune response.

View the frequently asked questions answered by Creative Biolabs Support.

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Biosimilar Overview

Please refer to Tocilizumab-Atlizumab Overview to learn more about the mechanism of action, clinical projects, and approved drugs of Tocilizumab-Atlizumab.

Downloadable Resources

Download resources about recombinant antibody development and antibody engineering to boost your research.

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Datasheet

Datasheet - TAB-026.pdf

MSDS

MSDS - TAB-026.pdf

COA

Certificate of Analysis Lookup

To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.

Lot Number:

Protocol & Troubleshooting

Immunofluorescence (IF)

We have outlined the assay protocols, covering reagents, solutions, procedures, and troubleshooting tips for common issues in order to better assist clients in conducting experiments with our products. View the full list of Protocol & Troubleshooting.

Isotype Control

CAT
Product Name

Secondary Antibody

CAT
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