Afuco™ Anti-IL6R ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-032ML)
CAT#: AFC-TAB-032ML
This product is an ADCC enhanced antibody produced by our Afuco™ platform. Recombinant monoclonal antibody to IL6R. It is a human monoclonal antibody that can be potentially used in the treatment of Neuromyelitis optica (NMO).
Tested Data
Gene Expression
WB
Figure 1 Human Anti-Human IL6R Antibody (AFC-TAB-032ML) in WB
Western blot analysis of AFC-TAB-032ML was performed by loading Human IL6R Protein (His Tag) in reduced condition Lane 1, Lane 2, Lane 3 (0.1 μg, 0.3 μg, 0.6 μg) onto a 12% Tris-HCl polyacrylamide gel. Proteins were transferred to a CN membrane and blocked with 5% skim milk for at least one hour. Membranes were probed with TAB-453CT (2 μg/mL) and HRP-conjugated goat anti-human IgG as a secondary antibody (1: 2000). Chemiluminescent detection was performed.
DB
Figure 2 Human Anti-Human IL6R Antibody (AFC-TAB-032ML) in DB
Dot Blot analysis of AFC-TAB-032ML was performed by coating with Human IL6R Protein (His Tag).
AFC-TAB-032ML incubation concentration: 2 μg/mL.
HRP-conjugated goat anti-human IgG as a secondary antibody (1: 2000)
ELISA
Figure 3 Human Anti-Human IL6R Antibody (AFC-TAB-032ML) in ELISA
ELISA analysis of AFC-TAB-032ML was performed by coating with Human IL6R Protein (His Tag). Then blocked with BSA and incubated with AFC-TAB-032ML. The HRP-conjugated goat anti-human IgG as a secondary antibody (1: 2000). Detection was performed using TMB substrate and stopped with sulfuric acid. The absorbances were read on a spectrophotometer at 450 nm.
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RNA Expression
Figure 1 RNA cell line category: Cell line enhanced (THP-1, U-266/84)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000160712-IL6R
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Specifications
- Immunogen
- The details of the immunogen for this antibody are not available.
- Host Species
- Human
- Derivation
- Humanized
- Type
- ADCC enhanced antibody
- Specificity
- Human IL6R
- Species Reactivity
- Human
- Applications
- ELISA, IHC, FC, IP, IF, FuncS
- Conjugate
- Unconjugated
- Generic Name
- Satralizumab
- Related Disease
- Neuromyelitis optica (NMO)
Product Property
- Purity
- >95% by SDS-PAGE
- Storage
- Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Target
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Biosimilar Overview
Please refer to Satralizumab Overview to learn more about the mechanism of action, clinical projects, and approved drugs of Satralizumab.
Downloadable Resources
Download resources about recombinant antibody development and antibody engineering to boost your research.
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
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Protocol & Troubleshooting
We have outlined the assay protocols, covering reagents, solutions, procedures, and troubleshooting tips for common issues in order to better assist clients in conducting experiments with our products. View the full list of Protocol & Troubleshooting.
See other products for "Satralizumab"
DrugMonitor™ Anti-Satralizumab Antibody (VS-1224-YC1063)Satralizumab is a subcutaneously injected anti-IL-6 receptor monoclonal antibody for the treatment of neuromyelitis optica spectrum disorder (NMOSD). The DrugMonitor™ Anti-Satralizumab Antibody (VS-1224-YC1063) is an anti-drug antibody (ADA) against Satralizumab. This drug-based antibody is raised in mice immunized with the Satralizumab. The anti-Satralizumab antibody may be used in ELISA, pharmacokinetics (PK), and pharmacodynamics (PD) analyses, or serves as a reference standard in ADA assays. It also is an excellent tool for therapeutic drug monitoring, allowing to evaluate the drug efficacy and determine the drug concentration of the Satralizumab in samples.
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| CAT | Product Name | Application | Type |
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| TAB-690LC-F(E) | Anti-human IL6R Fab Fragment (PM-1) | ELISA | |
| TAB-694LC-F(E) | Rabbit Anti-IL6R Recombinant Antibody; Fab Fragment (TAB-694LC-F(E)) | ELISA | Rabbit Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-691LC-S(P) | Human Anti-IL6R Recombinant Antibody; scFv Fragment (TAB-691LC-S(P)) | ELISA | Humanized scFv |
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| TAB-696LC-S(P) | Human Anti-IL6R Recombinant Antibody; scFv Fragment (TAB-696LC-S(P)) | ELISA | Humanized scFv |
| TAB-697LC-S(P) | Human Anti-IL6R Recombinant Antibody; scFv Fragment (TAB-697LC-S(P)) | ELISA | Humanized scFv |
| TAB-691LC-F(E) | Human Anti-IL6R Recombinant Antibody; Fab Fragment (TAB-691LC-F(E)) | ELISA | Humanized Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
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| CAT | Product Name | Application | Type |
|---|---|---|---|
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| NEUT-1490CQ | Mouse Anti-IL6R Recombinant Antibody (clone B-R6) | IHC-Fr, Inhib, FC, IP | Mouse IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0016-YC-F(E) | Human Anti-IL6R Recombinant Antibody; Fab Fragment (HPAB-0016-YC-F(E)) | ELISA, Neut | Human Fab |
| HPAB-0331-CN-F(E) | Human Anti-IL6R Recombinant Antibody (HPAB-0331-CN-F(E)); Fab Fragment | ELISA, FC, Neut | Human Fab |
| HPAB-0034-WJ-F(E) | Mouse Anti-IL6R Recombinant Antibody (clone 8C1D8B5); Fab Fragment | ELISA, WB | Mouse Fab |
| HPAB-1761LY-F(E) | Mouse Anti-IL6R Recombinant Antibody (clone G10); Fab Fragment | FC | Mouse Fab |
| HPAB-0165-YJ-F(E) | Human Anti-IL6R Recombinant Antibody; Fab Fragment (HPAB-0165-YJ-F(E)) | ELISA, Block, Inhib | Humanized Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0718-CN-S(P) | Human Anti-IL6R Recombinant Antibody; scFv Fragment (HPAB-0718-CN-S(P)) | ELISA, Neut | Humanized scFv |
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| AFC-TAB-026 | Afuco™ Anti-IL6R ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-026) | ELISA, FC, IP, FuncS, IF, Neut, ICC | ADCC enhanced antibody |
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| CAT | Product Name | Application | Type |
|---|---|---|---|
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| CAT | Product Name | Application | Type |
|---|---|---|---|
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| CAT | Product Name | Application | Type |
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| VS-0425-YC677 | Recombinant Anti-IL6R Vesicular Antibody, EV Displayed (VS-0425-YC677) | ELISA, FC, Neut, Cell-uptake |
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