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    JAK3

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    For Research Use Only. Not For Clinical Use.


    Background

    The protein encoded by this gene is a member of the Janus kinase (JAK) family of tyrosine kinases involved in cytokine receptor-mediated intracellular signal transduction. It is predominantly expressed in immune cells and transduces a signal in response to its activation via tyrosine phosphorylation by interleukin receptors. Mutations in this gene are associated with autosomal SCID (severe combined immunodeficiency disease).
    Protein class

    Cancer-related genes, Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Metabolic proteins

    Predicted location

    Intracellular

    Single cell type specificity

    Cell type enhanced (T-cells, B-cells, dendritic cells, NK-cells, Plasma cells, Macrophages)

    Immune cell specificity

    Low immune cell specificity

    Cell line specificity

    Cell line enhanced (HDLM-2, HEL, HMC-1, Karpas-707, U-266/70, U-266/84, U-937)

    Interaction

    Interacts with STAM2 and MYO18A (By similarity). Interacts with SHB.

    Molecular function

    Kinase, Transferase, Tyrosine-protein kinase

    More Types Infomation
    Related Diseases
    Non-small Cell Lung Cancer Non-small Cell Lung Cancer
    Pancreatic Cancer Pancreatic Cancer
    Primary Immunodeficiency Primary Immunodeficiency
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