Mouse Anti-JAK3 Recombinant Antibody (clone 6B5) (CAT#: VS3-WK1605)
This antibody is a mouse recombinant antibody against human JAK3, which is predominantly expressed in immune cells and transduces a signal in response to its activation via tyrosine phosphorylation by interleukin receptors. The clone 6B5 can be used in IHC analysis at a dilution of 1/50-1/200.
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Subcellular Location
Normal Tissue
RNA Expression
Figure 1 IF staining of human cell line HEL
(Immunofluorescent staining of human cell line HEL shows localization to plasma membrane & cytosol.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/70314/1813_H2_9_cr59f2f211a23e0_selected.jpg
(Immunofluorescent staining of human cell line HEL shows localization to plasma membrane & cytosol.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/70314/1813_H2_9_cr59f2f211a23e0_selected.jpg
Figure 2 Appendix
(High expression)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/70314/154739_A_3_2_val_selected.jpg
(High expression)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/70314/154739_A_3_2_val_selected.jpg
Figure 3 Testis
(Elongated or late spermatids Staining: Low Intensity: Weak Quantity:>75% Preleptotene spermatocytes Staining: Medium Intensity: Moderate Quantity: 75%-25% Spermatogonia cells Staining: Medium Intensity: Moderate)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/70314/154739_A_6_6.jpg
(Elongated or late spermatids Staining: Low Intensity: Weak Quantity:>75% Preleptotene spermatocytes Staining: Medium Intensity: Moderate Quantity: 75%-25% Spermatogonia cells Staining: Medium Intensity: Moderate)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/70314/154739_A_6_6.jpg
Figure 4 Lymph node
(Germinal center cells Staining: Medium Intensity: Strong Quantity: <25% Location: Cytoplasmic/ membranous Non-germinal center cells Staining: Medium Intensity: Strong Quantity: <25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/70314/154739_A_7_8.jpg
(Germinal center cells Staining: Medium Intensity: Strong Quantity: <25% Location: Cytoplasmic/ membranous Non-germinal center cells Staining: Medium Intensity: Strong Quantity: <25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/70314/154739_A_7_8.jpg
Figure 5 Tonsil
(Germinal center cells Staining: Medium Intensity: Strong Quantity: <25% Location: Cytoplasmic/ membranous Non-germinal center cells Staining: Medium Intensity: Strong Quantity: <25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/70314/154739_A_4_8.jpg
(Germinal center cells Staining: Medium Intensity: Strong Quantity: <25% Location: Cytoplasmic/ membranous Non-germinal center cells Staining: Medium Intensity: Strong Quantity: <25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/70314/154739_A_4_8.jpg
Figure 6 RNA cell line category: Cell line enhanced (HDLM-2, HEL, HMC-1, Karpas-707, U-266/70, U-266/84, U-937)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000105639-JAK3
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000105639-JAK3
Specifications
- Immunogen
- Synthesized peptide derived from human JAK3
- Host Species
- Mouse
- Type
- Mouse IgG
- Specificity
- Human JAK3
- Species Reactivity
- Human, Mouse, Rat
- Clone
- 6B5
- Applications
- IHC
- Conjugate
- Unconjugated
Product Property
- Clonality
- Monoclonal
- Purification
- Protein G affinity purified
- Purity
- >95% as determined by SDS-PAGE
- Aggregation
- < 5%
- Format
- Liquid
- Concentration
- 1 mg/mL
- Buffer
- PBS, 0.5% BSA, 50% Glycerol
- Preservative
- 0.02% Sodium Azide
- Storage
- Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- IHC: 1/50-1/200
Target
- Alternative Names
- JAKL; LJAK; JAK-3; L-JAK; JAK3_HUMAN
- Gene ID
- 3718
- UniProt ID
- P52333
- Long Name
- Janus kinase 3
- Sequence Similarities
- Belongs to the protein kinase superfamily. Tyr protein kinase family. JAK subfamily.
- Cellular Localization
- Cytoplasm, Membrane
- Post Translation Modifications
- Tyrosine phosphorylated in response to IL-2 and IL-4. Dephosphorylation of Tyr-980 and Tyr-981 by PTPN2 negatively regulates cytokine-mediated signaling (Probable).
- Protein Refseq
- NP_000206.2
- Function
- Non-receptor tyrosine kinase involved in various processes such as cell growth, development, or differentiation. Mediates essential signaling events in both innate and adaptive immunity and plays a crucial role in hematopoiesis during T-cells development.
Recommended Products
Secondary Antibody
Isotype Control
Related Resources
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Primary Immunodeficiency
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-0072CT | Recombinant Mouse anti-Human JAK3 Monoclonal antibody (6I3) | ELISA, ICC/IF, WB | |
| MRO-0882-CN | Recombinant Rabbit Anti-JAK3 Monoclonal Antibody (JM66-31) | WB, IHC, IF | Rabbit IgG |
| ZG-0781J | Rabbit Anti-JAK3 Recombinant Antibody (clone 1C7) | ELISA, IHC | Rabbit IgG |
| VS3-XY949 | Mouse Anti-JAK3 Recombinant Antibody (clone 5H2) | ELISA, WB, ICC, FC | Mouse IgG1 |
| VS7-0425-WR168 | Mouse Anti-JAK3 Monoclonal Antibody (VS7-0425-WR168) | WB, IF, ICC, FC, ELISA | Mouse IgG |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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