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KRT10
Loading...Anti-KRT10 Products
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- Species Reactivity: Dog, Human, Mouse, Rat, Pig, Zebrafish
- Type: Mouse IgG1
- Application: FC, ICC, IHC-Fr, WB
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- Derivation: Phage display library screening
- Species Reactivity: Human
- Type: IgG
- Application: ICC, IHC-P, IP, WB
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- Anti-KRT10 Immunohistochemistry Kit (VS-0325-XY1206)
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- Species Reactivity: Human, Mouse, Rat
- Target: KRT10
- Application: IHC
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- Rabbit Anti-KRT10 Recombinant Antibody (VS13-YC630) (VS13-YC630)
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- Species Reactivity: Human, Hamster, Mouse, Rat
- Type: Rabbit IgG
- Application: WB, IHC-P
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- Mouse Anti-KRT10 Recombinant Antibody (clone 3C2F5) (VS7-0425-WR248)
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- Species Reactivity: Human, Mouse, Monkey, Rat
- Type: Mouse IgG1
- Application: WB, IHC, FC
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- Mouse Anti-KRT10 Recombinant Antibody (clone 1C3D9) (VS7-0425-WR249)
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- Species Reactivity: Human, Monkey
- Type: Mouse IgG1
- Application: WB, IHC
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- Anti-Mouse KRT10 Immunohistochemistry Kit (VS-0525-XY3833)
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- Species Reactivity: Human, Mouse, Rat, Monkey
- Target: KRT10
- Application: IHC
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- Anti-Human KRT10 Immunohistochemistry Kit (VS-0525-XY3834)
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- Species Reactivity: Human, Canine
- Target: KRT10
- Application: IHC
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More Infomation
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For Research Use Only. Not For Clinical Use.
This gene encodes a member of the type I (acidic) cytokeratin family, which belongs to the superfamily of intermediate filament (IF) proteins. Keratins are heteropolymeric structural proteins which form the intermediate filament. These filaments, along with actin microfilaments and microtubules, compose the cytoskeleton of epithelial cells. Mutations in this gene are associated with epidermolytic hyperkeratosis. This gene is located within a cluster of keratin family members on chromosome 17q21. [provided by RefSeq, Jul 2008]
Protein class
Disease related genes, Human disease related genes, Plasma proteins
Predicted location
Intracellular, Secreted (different isoforms)
Single cell type specificity
Cell type enriched (Suprabasal keratinocytes)
Immune cell specificity
Low immune cell specificity
Cell line specificity
Cell line enriched (hTCEpi)
Interaction
Heterotetramer of two type I and two type II keratins. Heterodimer with KRT1 (PubMed:27595935). Two heterodimers of KRT1 and KRT10 form a heterotetramer (PubMed:27595935). The KRT10 subunit in the heterotetramer is probably disulfide-linked (Probable). (Microbial infection) Interacts (via C-terminal tail domain) with the S.aureus clumping factor, clfB; this interaction probably mediates S.aureus attachment to the keratinized squamous epithelial cells from the nasal cavity. (Microbial infection) Interacts (via the C-terminal tail domain) with S.pneumoniae serine-rich repeat protein PsrP; this interaction probably mediates S.pneumoniae adherence to lung tissue and subsequent pathogenesis. Neither protein has to be glycosylated for the interaction to occur.
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