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    For Research Use Only. Not For Clinical Use.


    Background

    MAPT, the gene encoding the Tau protein, is a microtubule-associated protein (MAP) primarily expressed in neurons of the central nervous system. Its main physiological function is to promote the assembly and stability of microtubules, which are crucial components of the neuronal cytoskeleton. Microtubules are essential for maintaining neuronal structure, facilitating axonal transport of organelles and vesicles, and supporting synaptic function. The proper functioning of Tau is intricately regulated by various post-translational modifications, with phosphorylation being the most critical.
    This gene encodes the microtubule-associated protein tau (MAPT) whose transcript undergoes complex, regulated alternative splicing, giving rise to several mRNA species. MAPT transcripts are differentially expressed in the nervous system, depending on stage of neuronal maturation and neuron type. MAPT gene mutations have been associated with several neurodegenerative disorders such as Alzheimer's disease, Pick's disease, frontotemporal dementia, cortico-basal degeneration and progressive supranuclear palsy.
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