PDK1

Recombinant Antibody Products Formats

Anti-PDK1 Recombinant Antibody Products

Mouse Anti-PDK1 Recombinant Antibody (clone 34H4) (MOB-2840z)
- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG1
- Application: WB, ELISA, FC, ICC, IF, IHC
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Recombinant Mouse Anti-Human PDK1 Antibody (clone 5B22) (MOB-1926MZ)
- Species Reactivity: Human
- Type: Mouse antibody
- Application: ELISA, FC, ICC/IF, IHC-P, WB
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Human Anti-PDK1 Recombinant Antibody (clone 2B9) (HPAB-0015-CN)
- Species Reactivity: Human
- Type: Human IgG1
- Application: IF, ELISA, FC
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Recombinant Rabbit Anti-PDK1 Monoclonal Antibody (JA67-30) (MRO-1198-CN)
- Species Reactivity: Human, Mouse, Rat
- Type: Rabbit IgG
- Application: WB, IHC, IP, FC
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Rabbit Anti-PDK1 Recombinant Antibody (clone JA67-30) (VS3-WK265)
- Derivation: Rabbit
- Species Reactivity: Human, Mouse, Rat
- Type: Rabbit IgG
- Application: WB, ELISA
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Mouse Anti-PDK1 Recombinant Antibody (clone 4A11) (VS3-XY1232)
- Species Reactivity: Human
- Type: Mouse IgG1
- Application: ELISA, WB, IHC, FC, ICC
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Rabbit Anti-PDK1 Recombinant Antibody (VS3-WK1313) (VS3-WK1313)
- Derivation: Rabbit
- Species Reactivity: Human, Rat, Mouse
- Type: Rabbit IgG
- Application: ELISA, IHC, WB
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Mouse Anti-NHP PDK1 Recombinant Antibody (clone 4A11) (VS-1024-XY374)
- Species Reactivity: Human, Mouse, Non-human primate, Rat
- Type: Mouse IgG1
- Application: WB, IHC, ELISA
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Human Anti-PDK1 Recombinant Antibody (clone 2B9); scFv Fragment (HPAB-0015-CN-S(P))
- Species Reactivity: Human
- Type: Human scFv
- Application: IF, ELISA, FC
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Human Anti-PDK1 Recombinant Antibody (clone 2B9); Fab Fragment (HPAB-0015-CN-F(E))
- Species Reactivity: Human
- Type: Human Fab
- Application: IF, ELISA, FC
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Hi-Affi™ Recombinant Rabbit Anti-PDK1 Monoclonal Antibody (DS2644AB) (MOR-2644)
- Derivation: Phage display library screening
- Species Reactivity: Mouse, Rat, Human
- Type: IgG
- Application: WB, IP
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For Research Use Only. Not For Clinical Use.

Pyruvate dehydrogenase (PDH) is a mitochondrial multienzyme complex that catalyzes the oxidative decarboxylation of pyruvate and is one of the major enzymes responsible for the regulation of homeostasis of carbohydrate fuels in mammals. The enzymatic activity is regulated by a phosphorylation/dephosphorylation cycle. Phosphorylation of PDH by a specific pyruvate dehydrogenase kinase (PDK) results in inactivation. Multiple alternatively spliced transcript variants have been found for this gene.

Protein class

Enzymes, FDA approved drug targets, Metabolic proteins, Plasma proteins

Predicted location

Intracellular

Single cell type specificity

Cell type enhanced (Plasma cells, Early spermatids)

Immune cell specificity

Low immune cell specificity

Cell line specificity

Cell line enhanced (U-266/70, U-87 MG)

Interaction

Homodimer, and heterodimer with PDK2. Interacts with the pyruvate dehydrogenase complex subunit DLAT, and is part of the multimeric pyruvate dehydrogenase complex that contains multiple copies of pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (DLAT, E2) and lipoamide dehydrogenase (DLD, E3).

Molecular function

Kinase, Transferase

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