Anti-PDK1 Products

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For Research Use Only. Not For Clinical Use.

Are you struggling with lengthy drug development cycles or inconsistent antibody performance in PDK1-related oncology studies? Unlock new insights into metabolic disorders with Creative Biolabs' anti-PDK1 recombinant antibodies. Engineered for superior performance, these antibodies are produced using advanced mammalian expression systems, ensuring high-fidelity protein folding and post-translational modifications crucial for target recognition. Our rigorous purification processes guarantee exceptional purity and lot-to-lot consistency, providing researchers with reliable and highly specific tools to precisely detect and quantify PDK1, facilitating robust and reproducible experimental outcomes in metabolic research

PDK1: A Master Regulator of Cellular Metabolism and Cancer Progression

3-Phosphoinositide-Dependent Protein Kinase 1 (PDK1) is a serine/threonine kinase central to the PI3K/AKT/mTOR signaling axis, orchestrating critical cellular processes including glucose metabolism, cell survival, and proliferation. PDK1 phosphorylates and activates AKT, amplifying oncogenic signaling cascades implicated in tumor growth, metastasis, and therapy resistance. Dysregulated PDK1 activity is strongly associated with cancers (e.g., breast, lung, colorectal), diabetes, and neurodegenerative diseases. Targeting PDK1 with high-specificity antibodies enables precise modulation of this signaling hub, offering transformative potential for therapeutic development and mechanistic studies.

Alternative Names

Phosphoinositide-dependent kinase-1; PDPK1; PDPK2; PRO0461; PDPK2P; 3-phosphoinositide dependent protein kinase 1.

Background

Pyruvate dehydrogenase (PDH) is a mitochondrial multienzyme complex that catalyzes the oxidative decarboxylation of pyruvate and is one of the major enzymes responsible for the regulation of homeostasis of carbohydrate fuels in mammals. The enzymatic activity is regulated by a phosphorylation/dephosphorylation cycle. Phosphorylation of PDH by a specific pyruvate dehydrogenase kinase (PDK) results in inactivation. Multiple alternatively spliced transcript variants have been found for this gene.

Anti-PDK1 rAb Products

Creative Biolabs offers anti-PDK1 recombinant antibodies that are developed to operate well in both in vitro and in vivo settings. Our products exhibit nanomolar affinity and minimal cross-reactivity, validated for ELISA, Western blot, immunohistochemistry, and functional inhibition assays. Customizable formats (e.g., IgG, Fab, scFv) and species reactivity (human, mouse, rat) ensure seamless integration into diverse experimental workflows

Table 1. Featured anti-PDK1 recombinant antibody products at Creative Biolabs.

Creative Quality Control

All anti-PDK1 antibodies go through a multi-tiered validation process that includes functional testing in PDK1-dependent cellular models, binding affinity profiling, and epitope mapping. Lot-specific data packages confirm >95% purity (HPLC/SDS-PAGE) and endotoxin levels <0.1 EU/µg. Our ISO-certified processes guarantee compliance with global regulatory standards, reducing experimental variability and accelerating translational research.

Customer Reviews

rAb Production

Our anti-PDK1 antibodies are produced using CHO cell-based expression systems, ensuring native glycosylation patterns and enhanced stability. Proprietary affinity chromatography and tag-free purification eliminate aggregation risks, yielding >90% monomeric antibodies. Scalable bioreactor processes enable bulk orders with 6-week turnaround times, maintaining identical performance from pilot to GMP-grade batches.

Featured Anti-PDK1 Recombinant Antibody Production Platforms
Fig.1 Milligram-scale anti-PDK1 recombinant antibody production.

Fig.2 Gram-scale anti-PDK1 recombinant antibody production.

rAb Modalities

Creative Biolabs offers anti-PDK1 antibodies in monoclonal, polyclonal, and fragment (e.g., Fab, scFv) formats, conjugated to HRP, FITC, or biotin for flexibility in multiplex assays. Species-specific variants (humanized, murine) support preclinical toxicology and companion diagnostic development.

Fig.7 Full-length anti-PDK1 recombinant antibody production and modalities.

Creative Biolabs is dedicated to empowering your scientific endeavors with top-tier anti-PDK1 recombinant antibody solutions. With considerable expertise and a strong dedication to quality, we are your reliable partner in advancing biological research and pharmaceutical development. Discover our comprehensive services and connect with us today to unlock your next scientific breakthrough.