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    RPS6KA1

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    For Research Use Only. Not For Clinical Use.


    This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains 2 nonidentical kinase catalytic domains and phosphorylates various substrates, including members of the mitogen-activated kinase (MAPK) signalling pathway. The activity of this protein has been implicated in controlling cell growth and differentiation. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
    Protein class

    Cancer-related genes, Enzymes, Metabolic proteins, Plasma proteins

    Predicted location

    Intracellular

    Single cell type specificity

    Cell type enhanced (Proximal enterocytes, Distal enterocytes, NK-cells, monocytes)

    Immune cell specificity

    Low immune cell specificity

    Cell line specificity

    Cell line enhanced (HMC-1, U-937)

    Interaction

    Forms a complex with either MAPK1/ERK2 or MAPK3/ERK1 in quiescent cells. Transiently dissociates following mitogenic stimulation. Interacts with ETV1/ER81 and FGFR1. (Microbial infection) Interacts with Kaposi's sarcoma-associated herpesvirus/HHV-8 protein ORF45; this interaction allows RPS6KA1 activation.

    Molecular function

    Kinase, Serine/threonine-protein kinase, Transferase

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