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SOD2

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For Research Use Only. Not For Clinical Use.


Background

This gene is a member of the iron/manganese superoxide dismutase family. It encodes a mitochondrial protein that forms a homotetramer and binds one manganese ion per subunit. This protein binds to the superoxide byproducts of oxidative phosphorylation and converts them to hydrogen peroxide and diatomic oxygen. Mutations in this gene have been associated with idiopathic cardiomyopathy (IDC), premature aging, sporadic motor neuron disease, and cancer. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
SOD2
Protein class

Cancer-related genes, Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets

Predicted location

Intracellular

Single cell type specificity

Cell type enhanced (Prostatic glandular cells, Basal respiratory cells)

Immune cell specificity

Immune cell enriched (neutrophil)

Cell line specificity

Cell line enhanced (BJ hTERT+, GAMG, HSkMC)

Interaction

Homotetramer.

Molecular function

Oxidoreductase

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