Anti-SOD2 (clone W24V127) Recombinant Antibody Coupled Liposome (VS-1024-FY129) (CAT#: VS-1024-FY129)
The binding of anti-SOD2 antibodies with liposomes demonstrates significant potential application value in the treatment of gliomas. This combination not only enhances the targeting of drugs but also improves their delivery efficiency within the tumor microenvironment. Studies have shown that antibodies targeting SOD2 can selectively attach to glioma cells, enabling precise treatment. Through this mechanism, therapeutic drugs can more effectively penetrate tumor cell membranes, increasing treatment efficacy and reducing damage to normal cells.
More Infomation
Subcellular Location
Normal Tissue
RNA Expression
Figure 1 IF staining of human cell line U-2 OS
(Immunofluorescent staining of human cell line U-2 OS shows localization to mitochondria.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/1814/1865_C5_1_selected.jpg
(Immunofluorescent staining of human cell line U-2 OS shows localization to mitochondria.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/1814/1865_C5_1_selected.jpg
Figure 2 Testis
(Leydig cells Staining: High Intensity: Strong Quantity:>75% Sertoli cells Staining: Medium Intensity: Moderate Quantity:>75% Spermatogonia cells Staining: High Intensity: Strong)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/2013/5464_A_6_6.jpg
(Leydig cells Staining: High Intensity: Strong Quantity:>75% Sertoli cells Staining: Medium Intensity: Moderate Quantity:>75% Spermatogonia cells Staining: High Intensity: Strong)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/2013/5464_A_6_6.jpg
Figure 3 Lymph node
(Germinal center cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous Non-germinal center cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/2013/5464_A_8_8.jpg
(Germinal center cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous Non-germinal center cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/2013/5464_A_8_8.jpg
Figure 4 Colon
(Endothelial cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Glandular cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous Peripheral nerve/ganglion Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/2013/5464_A_9_3.jpg
(Endothelial cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Glandular cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous Peripheral nerve/ganglion Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/2013/5464_A_9_3.jpg
Figure 5 Kidney
(Cells in tubules Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/2013/5464_A_7_5.jpg
(Cells in tubules Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/2013/5464_A_7_5.jpg
Figure 6 RNA cell line category: Cell line enhanced (BJ hTERT+, GAMG, HSkMC)
(Cell lines ordered by descending RNA expression order)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000112096-SOD2
(Cell lines ordered by descending RNA expression order)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000112096-SOD2
Specifications
- Potential Clinical Applications
- Glioma
Product Composition
- Clone
- W24V127
- Antibody Type
- IgG
- Antibody Host
- Mouse
- Antibody Reactivity
- Human
- Antibody Description
- This is a recombinant mouse monoclonal antibody that is designed to specifically recognize and bind to human superoxide dismutase 2 (SOD2). SOD2 is an essential enzyme that plays a critical role in protecting cells from oxidative stress by converting superoxide radicals into hydrogen peroxide and molecular oxygen. The specificity of this antibody for human SOD2 makes it a valuable tool for researchers studying oxidative stress, mitochondrial function, and related diseases in human models.
Product Property
- Storage
- See in the COA
- Storage Shelf Time
- See in the COA
Target Information
- Target
- SOD2
- Introduction
- This gene is a member of the iron/manganese superoxide dismutase family. It encodes a mitochondrial protein that forms a homotetramer and binds one manganese ion per subunit. This protein binds to the superoxide byproducts of oxidative phosphorylation and converts them to hydrogen peroxide and diatomic oxygen. Mutations in this gene have been associated with idiopathic cardiomyopathy (IDC), premature aging, sporadic motor neuron disease, and cancer. Alternative splicing of this gene results in multiple transcript variants. A related pseudogene has been identified on chromosome 1.
- Alternative Names
- Superoxide Dismutase 2; Superoxide Dismutase 2, Mitochondrial; EC 1.15.1.1; Manganese-Containing Superoxide Dismutase; Superoxide Dismutase [Mn], Mitochondrial; Mangano-Superoxide Dismutase; Mn Superoxide Dismutase
- Full Name
- Superoxide Dismutase 2
- Gene ID
- 6648
- UniProt ID
- P04179
- Sequence Similarities
- Belongs to the iron/manganese superoxide dismutase family.
- Post Translation Modifications
- Nitrated under oxidative stress.
Nitration coupled with oxidation inhibits the catalytic activity.
- Protein Refseq
- NP_000627.2; NP_001019636.1; NP_001019637.1; NP_001309743.1; NP_001309744.1
- Function
- Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems.
Downloads
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IgG Antibody Products
Rabbit Monoclonal Antibody Products
Antibody Magnetic Beads
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1985CT | Recombinant Mouse anti-Human SOD2 Monoclonal antibody (2BF) | ELISA, IP | |
| VS3-QX1040 | Mouse Anti-SOD2 Recombinant Antibody (clone 4C4-G8-H12) | WB | Mouse IgG2b |
| VS3-QX1041 | Mouse Anti-SOD2 Recombinant Antibody (clone 37CT127.5.11.6) | WB, IHC | Mouse IgG1, κ |
| VS-0923-FY139 | Recombinant Mouse Anti-SOD2 Antibody (VS-0923-FY139) | ELISA, WB, IHC | Mouse IgG1 |
| VS3-WK2198 | Rabbit Anti-SOD2 (acetyl K68) Recombinant Antibody (clone R69-3Z-7) | WB, IHC-P | Rabbit IgG |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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