Anti-SOD2 (clone W24V127) Recombinant Antibody Coupled Liposome (VS-1024-FY129)
CAT#: VS-1024-FY129
The binding of anti-SOD2 antibodies with liposomes demonstrates significant potential application value in the treatment of gliomas. This combination not only enhances the targeting of drugs but also improves their delivery efficiency within the tumor microenvironment. Studies have shown that antibodies targeting SOD2 can selectively attach to glioma cells, enabling precise treatment. Through this mechanism, therapeutic drugs can more effectively penetrate tumor cell membranes, increasing treatment efficacy and reducing damage to normal cells.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line U-2 OS
Immunofluorescent staining of human cell line U-2 OS shows localization to mitochondria.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/1814/1865_C5_1_selected.jpg
Normal Tissue
Figure 2 Testis
Leydig cells Staining: High Intensity: Strong Quantity:>75% Sertoli cells Staining: Medium Intensity: Moderate Quantity:>75% Spermatogonia cells Staining: High Intensity: Strong
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/2013/5464_A_6_6.jpg
Normal Tissue
Figure 3 Lymph node
Germinal center cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous Non-germinal center cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/2013/5464_A_8_8.jpg
Normal Tissue
Figure 4 Colon
Endothelial cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Glandular cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous Peripheral nerve/ganglion Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/2013/5464_A_9_3.jpg
Normal Tissue
Figure 5 Kidney
Cells in tubules Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/2013/5464_A_7_5.jpg
RNA Expression
Figure 6 RNA cell line category: Cell line enhanced (BJ hTERT+, GAMG, HSkMC)
Cell lines ordered by descending RNA expression order
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000112096-SOD2
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More Infomation
Specifications
- Potential Clinical Applications
- Glioma
Product Composition
- Clone
- W24V127
- Antibody Type
- IgG
- Antibody Host
- Mouse
- Antibody Reactivity
- Human
- Antibody Description
- This is a recombinant mouse monoclonal antibody that is designed to specifically recognize and bind to human superoxide dismutase 2 (SOD2). SOD2 is an essential enzyme that plays a critical role in protecting cells from oxidative stress by converting superoxide radicals into hydrogen peroxide and molecular oxygen. The specificity of this antibody for human SOD2 makes it a valuable tool for researchers studying oxidative stress, mitochondrial function, and related diseases in human models.
Product Property
- Storage
- See in the COA
- Storage Shelf Time
- See in the COA
Target Information
- Target
- SOD2
- Introduction
- This gene is a member of the iron/manganese superoxide dismutase family. It encodes a mitochondrial protein that forms a homotetramer and binds one manganese ion per subunit. This protein binds to the superoxide byproducts of oxidative phosphorylation and converts them to hydrogen peroxide and diatomic oxygen. Mutations in this gene have been associated with idiopathic cardiomyopathy (IDC), premature aging, sporadic motor neuron disease, and cancer. Alternative splicing of this gene results in multiple transcript variants. A related pseudogene has been identified on chromosome 1.
- Alternative Names
- Superoxide Dismutase 2; Superoxide Dismutase 2, Mitochondrial; EC 1.15.1.1; Manganese-Containing Superoxide Dismutase; Superoxide Dismutase [Mn], Mitochondrial; Mangano-Superoxide Dismutase; Mn Superoxide Dismutase
- Full Name
- Superoxide Dismutase 2
- Gene ID
- 6648
- UniProt ID
- P04179
- Sequence Similarities
- Belongs to the iron/manganese superoxide dismutase family.
- Post Translation Modifications
- Nitrated under oxidative stress.
Nitration coupled with oxidation inhibits the catalytic activity.
- Protein Refseq
- NP_000627.2; NP_001019636.1; NP_001019637.1; NP_001309743.1; NP_001309744.1
- Function
- Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems.
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Datasheet
MSDS
COA
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See other products for "SOD2"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1837z | Mouse Anti-SOD2 Recombinant Antibody (clone 28F7) | WB, ELISA, FC, ICC, IHC | Mouse IgG1 |
| MOB-1985CT | Recombinant Mouse anti-Human SOD2 Monoclonal antibody (2BF) | ELISA, IP | |
| MRO-1418-CN | Recombinant Rabbit Anti-SOD2 Monoclonal Antibody (CBACN-516) | WB, IHC | Rabbit IgG |
| ZG-0575U | Rabbit Anti-SOD2 Recombinant Antibody (clone 10F6) | ELISA, WB, IHC | Rabbit IgG |
| VS3-QX1040 | Mouse Anti-SOD2 Recombinant Antibody (clone 4C4-G8-H12) | WB | Mouse IgG2b |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-3370 | Hi-Affi™ Recombinant Rabbit Anti-SOD2 Monoclonal Antibody (DS3370AB) | WB, IHC, ICC | IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0724-YC500 | AbPlus™ Anti-SOD2 Magnetic Beads (VS-0724-YC500) | IP, Protein Purification |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-XY2142 | Anti-SOD2 Immunohistochemistry Kit | IHC | |
| VS-0525-XY6805 | Anti-Rat SOD2 Immunohistochemistry Kit | IHC | |
| VS-0525-XY6804 | Anti-Human SOD2 Immunohistochemistry Kit | IHC |
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