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SOST

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Sclerostin is a secreted glycoprotein with a C-terminal cysteine knot-like (CTCK) domain and sequence similarity to the DAN (differential screening-selected gene aberrative in neuroblastoma) family of bone morphogenetic protein (BMP) antagonists. Loss-of-function mutations in this gene are associated with an autosomal-recessive disorder, sclerosteosis, which causes progressive bone overgrowth. A deletion downstream of this gene, which causes reduced sclerostin expression, is associated with a milder form of the disorder called van Buchem disease.

Derivation:
Humanized
Species Reactivity:
Human
Type:
Antibody
Targets:
DKKl & SOST
Type:
TandAb
Application:
FuncS, Promising therapeutic agent
Derivation:
Llama immuniezd library
Species Reactivity:
Human, Mouse
Type:
Single domain antibody
Application:
WB, ELSA, FC
Derivation:
Llama immuniezd library
Species Reactivity:
Human, Mouse
Type:
Single domain antibody
Application:
WB, ELSA, FC
Derivation:
Llama immuniezd library
Species Reactivity:
Human, Mouse
Type:
Single domain antibody
Application:
WB, ELSA, FC
Derivation:
Llama immuniezd library
Species Reactivity:
Human, Mouse
Type:
Single domain antibody
Application:
WB, ELSA, FC
Derivation:
Llama immuniezd library
Species Reactivity:
Human, Mouse
Type:
Single domain antibody
Application:
WB, ELSA, FC
Derivation:
Llama immuniezd library
Species Reactivity:
Human, Mouse
Type:
Single domain antibody
Application:
WB, ELSA, FC
Derivation:
Llama immuniezd library
Species Reactivity:
Human, Mouse
Type:
Single domain antibody
Application:
WB, ELSA, FC
Derivation:
Llama immuniezd library
Species Reactivity:
Human, Mouse
Type:
Single domain antibody
Application:
WB, ELSA, FC
Derivation:
Llama immuniezd library
Species Reactivity:
Human, Mouse
Type:
Single domain antibody
Application:
WB, ELSA, FC
Derivation:
Humanized (from mouse)
Species Reactivity:
Human
Type:
IgG2 - kappa
Application:
IF, IP, Neut, FuncS, ELISA, FC, ICC
Derivation:
Humanized (from mouse)
Species Reactivity:
Human
Type:
IgG4 - kappa
Application:
FuncS, IF, Neut, ELISA, FC, IP, ICC
Species Reactivity:
Human
Type:
Human antibody
Application:
ELISA, Neut
Species Reactivity:
Human
Type:
Human antibody
Application:
ELISA, Neut
Species Reactivity:
Human
Type:
Human antibody
Application:
ELISA, Neut
Species Reactivity:
Human
Type:
Human antibody
Application:
ELISA, Neut
Species Reactivity:
Human, Cyno, Mouse. Rat
Type:
Human antibody
Application:
ELISA
Species Reactivity:
Human, Cyno, Mouse. Rat
Type:
Human antibody
Application:
ELISA
Species Reactivity:
Human, Cyno, Mouse. Rat
Type:
Human antibody
Application:
ELISA
Species Reactivity:
Human, Cyno, Mouse. Rat
Type:
Human antibody
Application:
ELISA
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