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TM4SF5
The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein and is highly similar in sequence and structure to transmembrane 4 superfamily member 1. It may play a role in cell proliferation, and overexpression of this protein may be associated with the uncontrolled growth of tumour cells.
Protein class
Transporters
Predicted location
Membrane
Single cell type specificity
Cell type enhanced (Proximal enterocytes, Paneth cells, Hepatocytes, Intestinal goblet cells, Enteroendocrine cells)
Immune cell specificity
Not detected in immune cells
Cell line specificity
Group enriched (CACO-2, Hep G2, OE19)
Interaction
Interacts with MTOR; the interaction is positively regulated by arginine and is negatively regulated by leucine (PubMed:30956113). Interacts with SLC38A9 (PubMed:30956113). Interacts with SLC7A1; the interaction is negatively regulated by arginine (PubMed:30956113). Interacts with CASTOR1; the interaction is positively regulated by leucine and is negatively regulated by arginine (PubMed:30956113).
More Types Infomation
- Rabbit Anti-TM4SF5 Polyclonal Antibody (MOB-0350MC)
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- Species Reactivity: Human
- Type: Rabbit IgG
- Application: ELISA, IHC
- Human Anti-TM4SF5 Recombinant Antibody (clone hEC2-C-1) (FAMAB-0707WJ)
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- Derivation: Humanized
- Species Reactivity: Human
- Type: Human IgG
- Application: ELISA, WB
- Mouse Anti-TM4SF5 Recombinant Antibody (clone mEC2-C) (FAMAB-0706WJ)
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- Derivation: Hybridoma
- Species Reactivity: Human
- Type: Mouse IgG
- Application: ELISA, WB
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- Species Reactivity: Human
- Type: Human scFv
- Application: ELISA, FC, Inhib
-
- Species Reactivity: Human
- Type: Human scFv
- Application: ELISA, FC, Inhib
-
- Species Reactivity: Human
- Type: Human scFv
- Application: ELISA, FC, Inhib
-
- Species Reactivity: Human
- Type: Human scFv
- Application: ELISA, FC, Inhib
-
- Species Reactivity: Human
- Type: Human antibody
- Application: ELISA, FC, Inhib
-
- Species Reactivity: Human
- Type: Human antibody
- Application: ELISA, FC, Inhib
-
- Species Reactivity: Human
- Type: Human antibody
- Application: ELISA, FC, Inhib
-
- Species Reactivity: Human
- Type: Mouse IgG
- Application: ELISA, FC, Inhib
- Anti-Human TM4SF5 Recombinant Antibody (TAB-615CL)
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- Species Reactivity: Human
- Type: Antibody
- Human Anti-TM4SF5 Recombinant Antibody; scFv Fragment (HPAB-N0263-YC-S(P)) (HPAB-N0263-YC-S(P))
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- Derivation: Humanized
- Species Reactivity: Human
- Type: Humanized scFv
- Application: ELISA, FC, Inhib, FuncS
- Human Anti-TM4SF5 Recombinant Antibody; Fab Fragment (HPAB-0103-WJ-F(E)) (HPAB-0103-WJ-F(E))
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- Species Reactivity: Human
- Type: Human Fab
- Application: ELISA
-
- Species Reactivity: Human
- Type: Human scFv
- Application: ELISA, FC, Inhib
- Human Anti-TM4SF5 Recombinant Antibody (HPAB-0103-WJ) (HPAB-0103-WJ)
-
- Species Reactivity: Human
- Type: Human IgG2a, κ
- Application: ELISA, SPR, IHC, Inhib, IF, WB
- Human Anti-TM4SF5 Recombinant Antibody (HPAB-N0263-YC) (HPAB-N0263-YC)
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- Derivation: Humanized
- Species Reactivity: Human
- Type: Humanized IgG
- Application: ELISA, FC, Inhib, FuncS
-
- Species Reactivity: Human
- Type: Human Fab
- Application: ELISA, FC, Inhib
-
- Species Reactivity: Human
- Type: Human Fab
- Application: ELISA, FC, Inhib
- Mouse Anti-TM4SF5 Recombinant Antibody; scFv Fragment (HPAB-0103-WJ-S(P)) (HPAB-0103-WJ-S(P))
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- Species Reactivity: Human
- Type: Mouse scFv
- Application: ELISA
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For Research Use Only. Not For Clinical Use.