Human Anti-TM4SF5 (clone hEC2-C-2) scFv-Fc Chimera
CAT#: VS-0325-FY172
This anti-TM4SF5 scFv-Fc antibody consists of a murine single-chain variable fragment (scFv) specific for human TM4SF5, fused to a human IgG1 Fc domain. This design allows the antibodies to specifically target and bind to TM4SF5 on cancer cells, leading to inhibition of cancer cell proliferation and invasion, enhancement of anoikis sensitivity, and reduction of tumor growth. These antibodies also have the potential to induce antibody-dependent cell-mediated cytotoxicity (ADCC), further contributing to their anti-cancer activity.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line Hep G2
Immunofluorescent staining of human cell line Hep G2 shows localization to nucleoplasm & cell junctions.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/55674/1144_G10_1_selected.jpg
RNA Expression
Figure 2 RNA cell line category: Group enriched (CACO-2, Hep G2, OE19)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000142484-TM4SF5
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Specifications
- Immunogen
- TM4SF5 peptide vaccine composed of the cyclic TM4SF5 peptide (hTM4SF5EC2-C).
- Host Species
- Human
- Type
- Human IgG1, scFv-Fc
- Specificity
- Human TM4SF5
- Species Reactivity
- Human
- Clone
- hEC2-C-2
- Applications
- ELISA, Western Blot, Immunoprecipitation, Immunofluorescence, Immunohistochemistry
- Related Disease
- Cancer
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- Immunofluorescence: 10 μg/mL
Target
- Alternative Names
- Transmembrane 4 L Six Family Member 5; Transmembrane 4 Superfamily Member 5; Tetraspan Transmembrane Protein L6H
- Gene ID
- 9032
- UniProt ID
- O14894
- Long Name
- Transmembrane 4 L Six Family Member 5
- Sequence Similarities
- Belongs to the L6 tetraspanin family.
- Cellular Localization
- Lysosome membrane; Cell membrane
- Post Translation Modifications
- Glycosylation at Asn138 and Asn155
Glycosylation from GlyGen 2 sites
- Protein Refseq
- NP_003954.2
- Function
- Human TM4SF5 (Tetraspanin membrane 4 superfamily member 5) is a transmembrane protein involved in cell adhesion, migration, and signaling. It plays a role in tumor progression and metastasis, and is associated with various cancers.
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Downloadable Resources
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
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Protocol & Troubleshooting
We have outlined the assay protocols, covering reagents, solutions, procedures, and troubleshooting tips for common issues in order to better assist clients in conducting experiments with our products. View the full list of Protocol & Troubleshooting.
Isotype Control
- CAT
- Product Name
Secondary Antibody
- CAT
- Product Name
See other products for "TM4SF5"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-693CT | Mouse Anti-TM4SF5 Recombinant Antibody (TAB-693CT) | ELISA, FC, Inhib | Mouse IgG |
| TAB-694CT | Human Anti-TM4SF5 Recombinant Antibody (TAB-694CT) | ELISA, FC, Inhib | Human antibody |
| TAB-695CT | Human Anti-TM4SF5 Recombinant Antibody (TAB-695CT) | ELISA, FC, Inhib | Human antibody |
| TAB-696CT | Human Anti-TM4SF5 Recombinant Antibody (TAB-696CT) | ELISA, FC, Inhib | Human antibody |
| TAB-697CT | Human Anti-TM4SF5 Recombinant Antibody (TAB-697CT) | ELISA, FC, Inhib | Human antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-0350MC | Rabbit Anti-TM4SF5 Polyclonal Antibody | ELISA, IHC | Rabbit IgG |
| HPAB-N0263-YC | Human Anti-TM4SF5 Recombinant Antibody (HPAB-N0263-YC) | ELISA, FC, Inhib, FuncS | Humanized IgG |
| HPAB-0103-WJ | Human Anti-TM4SF5 Recombinant Antibody (HPAB-0103-WJ) | ELISA, SPR, IHC, Inhib, IF, WB | Human IgG2a, κ |
| FAMAB-0706WJ | Mouse Anti-TM4SF5 Recombinant Antibody (clone mEC2-C) | ELISA, WB | Mouse IgG |
| FAMAB-0707WJ | Human Anti-TM4SF5 Recombinant Antibody (clone hEC2-C-1) | ELISA, WB | Human IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-N0263-YC-S(P) | Human Anti-TM4SF5 Recombinant Antibody; scFv Fragment (HPAB-N0263-YC-S(P)) | ELISA, FC, Inhib, FuncS | Humanized scFv |
| HPAB-0103-WJ-S(P) | Mouse Anti-TM4SF5 Recombinant Antibody; scFv Fragment (HPAB-0103-WJ-S(P)) | ELISA | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-N0263-YC-F(E) | Human Anti-TM4SF5 Recombinant Antibody; Fab Fragment (HPAB-N0263-YC-F(E)) | ELISA, FC, Inhib, FuncS | Humanized Fab |
| HPAB-0103-WJ-F(E) | Human Anti-TM4SF5 Recombinant Antibody; Fab Fragment (HPAB-0103-WJ-F(E)) | ELISA | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-YC101 | Recombinant Anti-TM4SF5 Vesicular Antibody, EV Displayed (VS-0425-YC101) | ELISA, FC, Inhib, Cell-uptake |
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