Human Anti-TM4SF5 (clone hEC2-C-2) scFv-Fc Chimera (CAT#: VS-0325-FY172)
This anti-TM4SF5 scFv-Fc antibody consists of a murine single-chain variable fragment (scFv) specific for human TM4SF5, fused to a human IgG1 Fc domain. This design allows the antibodies to specifically target and bind to TM4SF5 on cancer cells, leading to inhibition of cancer cell proliferation and invasion, enhancement of anoikis sensitivity, and reduction of tumor growth. These antibodies also have the potential to induce antibody-dependent cell-mediated cytotoxicity (ADCC), further contributing to their anti-cancer activity.
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Subcellular Location
RNA Expression
Figure 1 IF staining of human cell line Hep G2
(Immunofluorescent staining of human cell line Hep G2 shows localization to nucleoplasm & cell junctions.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/55674/1144_G10_1_selected.jpg
(Immunofluorescent staining of human cell line Hep G2 shows localization to nucleoplasm & cell junctions.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/55674/1144_G10_1_selected.jpg
Figure 2 RNA cell line category: Group enriched (CACO-2, Hep G2, OE19)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000142484-TM4SF5
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000142484-TM4SF5
Specifications
- Immunogen
- TM4SF5 peptide vaccine composed of the cyclic TM4SF5 peptide (hTM4SF5EC2-C).
- Host Species
- Human
- Type
- Human IgG1, scFv-Fc
- Specificity
- Human TM4SF5
- Species Reactivity
- Human
- Clone
- hEC2-C-2
- Applications
- ELISA, Western Blot, Immunoprecipitation, Immunofluorescence, Immunohistochemistry
- Related Disease
- Cancer
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- Immunofluorescence: 10 μg/mL
Target
- Alternative Names
- Transmembrane 4 L Six Family Member 5; Transmembrane 4 Superfamily Member 5; Tetraspan Transmembrane Protein L6H
- Gene ID
- 9032
- UniProt ID
- O14894
- Long Name
- Transmembrane 4 L Six Family Member 5
- Sequence Similarities
- Belongs to the L6 tetraspanin family.
- Cellular Localization
- Lysosome membrane; Cell membrane
- Post Translation Modifications
- Glycosylation at Asn138 and Asn155
Glycosylation from GlyGen 2 sites
- Protein Refseq
- NP_003954.2
- Function
- Human TM4SF5 (Tetraspanin membrane 4 superfamily member 5) is a transmembrane protein involved in cell adhesion, migration, and signaling. It plays a role in tumor progression and metastasis, and is associated with various cancers.
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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Human Antibody Products
IgG Antibody Products
ScFv Antibody Products
Fab Antibody Products
Extracellular Vesicle (EV) Antibody Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-693CT-F(E) | Human Anti-TM4SF5 Recombinant Antibody; Fab Fragment (TAB-693CT-F(E)) | ELISA, FC, Inhib | Human Fab |
| TAB-694CT-F(E) | Human Anti-TM4SF5 Recombinant Antibody; Fab Fragment (TAB-694CT-F(E)) | ELISA, FC, Inhib | Human Fab |
| TAB-695CT-F(E) | Human Anti-TM4SF5 Recombinant Antibody; Fab Fragment (TAB-695CT-F(E)) | ELISA, FC, Inhib | Human Fab |
| TAB-696CT-F(E) | Human Anti-TM4SF5 Recombinant Antibody; Fab Fragment (TAB-696CT-F(E)) | ELISA, FC, Inhib | Human Fab |
| TAB-697CT-F(E) | Human Anti-TM4SF5 Recombinant Antibody; Fab Fragment (TAB-697CT-F(E)) | ELISA, FC, Inhib | Human Fab |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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