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    TNFSF11

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    For Research Use Only. Not For Clinical Use.


    This gene encodes a member of the tumor necrosis factor (TNF) cytokine family which is a ligand for osteoprotegerin and functions as a key factor for osteoclast differentiation and activation. This protein was shown to be a dentritic cell survival factor and is involved in the regulation of T cell-dependent immune response. T cell activation was reported to induce expression of this gene and lead to an increase of osteoclastogenesis and bone loss. This protein was shown to activate antiapoptotic kinase AKT/PKB through a signaling complex involving SRC kinase and tumor necrosis factor receptor-associated factor (TRAF) 6, which indicated this protein may have a role in the regulation of cell apoptosis. Targeted disruption of the related gene in mice led to severe osteopetrosis and a lack of osteoclasts. The deficient mice exhibited defects in early differentiation of T and B lymphocytes, and failed to form lobulo-alveolar mammary structures during pregnancy. Two alternatively spliced transcript variants have been found.
    TNFSF11
    Protein class

    Cancer-related genes, CD markers, Disease related genes, FDA approved drug targets, Human disease related genes

    Predicted location

    Intracellular, Membrane, Secreted (different isoforms)

    Single cell type specificity

    Cell type enhanced (Late spermatids, Breast glandular cells, Early spermatids, Ductal cells, Breast myoepithelial cells)

    Immune cell specificity

    Immune cell enriched (NK-cell)

    Cell line specificity

    Cell line enhanced (HSkMC, NTERA-2)

    Interaction

    Homotrimer (By similarity). Interacts with TNFRSF11B (PubMed:22664871). Interacts with TNFRSF11A. Interacts with FBN1 (via N-terminal domain) in a Ca(+2)-dependent manner (By similarity). Interacts with TNFAIP6 (via both Link and CUB domains).

    Molecular function

    Cytokine, Developmental protein, Receptor

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