Anti-Human RANKL Recombinant Antibody scFv Fragment (XPA 12 042) (CAT#: TAB-308CT-S(P))
Recombinant monoclonal antibody specifically binds to human RANKL and inhibits osteoclastogenesis. This antibody can effectively alleviate the apoptotic effects induced by TNF-a and against ovarian ablation induced osteoporosis model.
Specific Inquiry
Normal Tissue
RNA Expression
Figure 1 High expression in lymph node
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/45142/ihc_selected.jpg
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/45142/ihc_selected.jpg
Figure 2 Low expression in cerebral cortex
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/45142/114242_B_7_5_val_selected.jpg
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/45142/114242_B_7_5_val_selected.jpg
Figure 3 IHC staining of human bone marrow
(Immunohistochemical staining of human bone marrow shows moderate positivity in hematopoietic cells.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/9193/ihc_selected.jpg
(Immunohistochemical staining of human bone marrow shows moderate positivity in hematopoietic cells.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/9193/ihc_selected.jpg
Figure 4 Lymph node
(Germinal center cells Staining: Medium Intensity: Strong Quantity: <25% Location: Cytoplasmic/ membranous Non-germinal center cells Staining: Medium Intensity: Strong Quantity: <25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/45142/114242_A_8_8.jpg
(Germinal center cells Staining: Medium Intensity: Strong Quantity: <25% Location: Cytoplasmic/ membranous Non-germinal center cells Staining: Medium Intensity: Strong Quantity: <25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/45142/114242_A_8_8.jpg
Figure 5 RNA cell line category: Cell line enhanced (HSkMC, NTERA-2)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000120659-TNFSF11
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000120659-TNFSF11
Specifications
- Host Species
- Human
- Type
- Human antibody
- Specificity
- Human
- Species Reactivity
- Human
- Clone
- XPA 12 042
- Applications
- Used for immunoassay techniques such as: Western Blot; Enzyme-linked Immunosorbent Assay; Flow Cytometry; Blocking
- Related Disease
- Osteoporosis model
Target
- Alternative Names
- TNFSF11; tumor necrosis factor (ligand) superfamily; member 11; ODF; OPGL; sOdf; CD254; OPTB2; RANKL; TRANCE; hRANKL2; tumor necrosis factor ligand superfamily member 11; osteoprotegerin ligand; osteoclast differentiation factor; TNF-related activation-induced cytokine; receptor activator of nuclear factor kappa B ligand; receptor activator of nuclear factor kappa-B ligand
- Gene ID
- 8600
- UniProt ID
- O14788
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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Antibody Magnetic Beads
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-H18 | Human Anti-TNFSF11 Recombinant Antibody (TAB-H18) | Neut, ELISA, IF, IP, FuncS, FC, ICC | Human IgG2 |
| TAB-299CT | Anti-Human RANKL Recombinant Antibody (RL1) | ELISA | Human antibody |
| TAB-300CT | Anti-Human RANKL Recombinant Antibody (RL2) | ELISA | Human antibody |
| TAB-301CT | Anti-Human RANKL Recombinant Antibody (RL3) | ELISA | Human antibody |
| TAB-302CT | Anti-Human RANKL Recombinant Antibody (RL4) | ELISA | Human antibody |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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