Mouse Anti-TNFSF11 Recombinant Antibody (clone 2A4); scFv Fragment (CAT#: HPAB-0072-YJ-S(P))
This product is a recombinant mouse scFv that recognizes human RANKL. Mab 2A4 is a neutralizing and can be used in the treatment of osteopenic diseases, including rheumatoid arthritis (RA), osteoporosis (OP), metastatic and primary bone cancer, wear debris-induced osteolysis or osteoarthritis (OA), or immune diseases, including psoriasis, insulin dependent, diabetes (IDDM), inflammatory bowel disease (IBD), or multiple sclerosis (MS).
Specific Inquiry
Normal Tissue
RNA Expression
Figure 1 High expression in lymph node
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/45142/ihc_selected.jpg
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/45142/ihc_selected.jpg
Figure 2 Low expression in cerebral cortex
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/45142/114242_B_7_5_val_selected.jpg
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/45142/114242_B_7_5_val_selected.jpg
Figure 3 IHC staining of human bone marrow
(Immunohistochemical staining of human bone marrow shows moderate positivity in hematopoietic cells.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/9193/ihc_selected.jpg
(Immunohistochemical staining of human bone marrow shows moderate positivity in hematopoietic cells.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/9193/ihc_selected.jpg
Figure 4 Lymph node
(Germinal center cells Staining: Medium Intensity: Strong Quantity: <25% Location: Cytoplasmic/ membranous Non-germinal center cells Staining: Medium Intensity: Strong Quantity: <25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/45142/114242_A_8_8.jpg
(Germinal center cells Staining: Medium Intensity: Strong Quantity: <25% Location: Cytoplasmic/ membranous Non-germinal center cells Staining: Medium Intensity: Strong Quantity: <25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/45142/114242_A_8_8.jpg
Figure 5 RNA cell line category: Cell line enhanced (HSkMC, NTERA-2)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000120659-TNFSF11
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000120659-TNFSF11
Specifications
- Immunogen
- Soluble human RANKL protein.
- Host Species
- Mouse
- Type
- Mouse scFv
- Specificity
- Human TNFSF11
- Species Reactivity
- Human
- Clone
- 2A4
- Applications
- IA, ELISA, Neut
- Related Disease
- Type 1 Diabetes, Inflammatory Bowel Disease, Multiple Sclerosis, Rheumatoid Arthritis, Psoriatics, Bone Diseases
Product Property
- Purity
- >95% as determined by SDS-PAGE and HPLC analysis
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- PBS
- Preservative
- No preservatives
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Target
- Alternative Names
- TNF Superfamily Member 11; Tumor Necrosis Factor (Ligand) Superfamily, Member 11; TNF-Related Activation-Induced Cytokine; Osteoclast Differentiation Factor; Osteoprotegerin Ligand; TRANCE; RANKL; OPGL; ODF; Receptor Activator Of Nuclear Factor Kappa B Ligand; Receptor Activator Of Nuclear Factor Kappa-B Ligand; MAb 2A4
- Gene ID
- 8600
- UniProt ID
- O14788
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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See other products for "Clone 2A4"
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Human Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-H18 | Human Anti-TNFSF11 Recombinant Antibody (TAB-H18) | Neut, ELISA, IF, IP, FuncS, FC, ICC | Human IgG2 |
| TAB-299CT | Anti-Human RANKL Recombinant Antibody (RL1) | ELISA | Human antibody |
| TAB-300CT | Anti-Human RANKL Recombinant Antibody (RL2) | ELISA | Human antibody |
| TAB-301CT | Anti-Human RANKL Recombinant Antibody (RL3) | ELISA | Human antibody |
| TAB-302CT | Anti-Human RANKL Recombinant Antibody (RL4) | ELISA | Human antibody |
Mouse Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-310CT | Anti-Human RANKL Recombinant Antibody | ELISA, FC, Neut | |
| TAB-310CT-S(P) | Anti-Human RANKL Recombinant Antibody scFv Fragment | ELISA, FC, Neut | |
| TAB-310CT-F(E) | Anti-Human RANKL Recombinant Antibody Fab Fragment | ELISA, FC, Neut |
Blocking Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-2178CQ | Rat Anti-Tnfsf11 Recombinant Antibody (clone IK22/5) | Block, FC, IP, WB | Rat IgG2a, κ |
Neutralizing Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-2179CQ | Mouse Anti-TNFSF11 Recombinant Antibody (clone CBL188) | IHC, Neut, WB | Mouse IgG2 |
| NEUT-2180CQ | Mouse Anti-TNFSF11 Recombinant Antibody (clone CBL488) | IHC, Neut | Mouse IgG2b |
| NEUT-2181CQ | Mouse Anti-TNFSF11 Recombinant Antibody (clone CBL578) | Neut | Mouse IgG1 |
Rabbit Monoclonal Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-3619 | Rabbit Anti-TNFSF11 Recombinant Antibody (clone DS3619AB) | WB, ICC, IP | Rabbit IgG |
scFv Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0171-YC-S(P) | Human Anti-TNFSF11 Recombinant Antibody; scFv Fragment (HPAB-0171-YC-S(P)) | ELISA, Neut | Human scFv |
| HPAB-0172-YC-S(P) | Human Anti-TNFSF11 Recombinant Antibody; scFv Fragment (HPAB-0172-YC-S(P)) | ELISA | Human scFv |
| HPAB-0173-YC-S(P) | Human Anti-TNFSF11 Recombinant Antibody; scFv Fragment (HPAB-0173-YC-S(P)) | ELISA | Human scFv |
| HPAB-1926-FY-F(E) | Human Anti-TNFSF11 Recombinant Antibody (clone 18B2); scFv Fragment | IP, ELISA | Human scFv |
| HPAB-1927-FY-F(E) | Human Anti-TNFSF11 Recombinant Antibody (clone 2D8); scFv Fragment | IP, ELISA | Human scFv |
Recombinant Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0874-CN-VHH | Camelid Anti-TNFSF11 Recombinant Single Domain Antibody (HPAB-0874-CN-VHH) | ELISA, FC, Neut | Camelid VHH |
| HPAB-0875-CN-VHH | Camelid Anti-TNFSF11 Recombinant Single Domain Antibody (HPAB-0875-CN-VHH) | ELISA, FC, Neut | Camelid VHH |
| HPAB-0072-YJ | Mouse Anti-TNFSF11 Recombinant Antibody (clone 2A4) | IA, ELISA, Neut | Mouse IgG2a, κ |
| HPAB-0075-YJ | Mouse Anti-TNFSF11 Recombinant Antibody (clone 19H22) | ELISA | Mouse IgG2b, κ |
| HPAB-0404-YJ | Rabbit Anti-TNFSF11 Recombinant Antibody (HPAB-0404-YJ) | ELISA, FC, Neut, Inhib, FuncS | Rabbit IgG2, κ |
Fab Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0685-CN-F(E) | Human Anti-TNFSF11 Recombinant Antibody (HPAB-0685-CN-F(E)); Fab Fragment | Neut | Human Fab |
| HPAB-0686-CN-F(E) | Human Anti-TNFSF11 Recombinant Antibody (HPAB-0686-CN-F(E)); Fab Fragment | Neut | Human Fab |
| HPAB-N0284-YC-F(E) | Human Anti-TNFSF11 Recombinant Antibody; Fab Fragment (HPAB-N0284-YC-F(E)) | ELISA, Neut, Inhib | Humanized Fab |
| HPAB-N0285-YC-F(E) | Mouse Anti-TNFSF11 Recombinant Antibody; Fab Fragment (HPAB-N0285-YC-F(E)) | Neut, FuncS | Mouse Fab |
| HPAB-0404-YJ-F(E) | Rabbit Anti-TNFSF11 Recombinant Antibody; Fab Fragment (HPAB-0404-YJ-F(E)) | ELISA, FC, Neut, Inhib, FuncS | Rabbit Fab |
ADCC Enhanced Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AFC-TAB-H18 | Afuco™ Anti-TNFSF11 Recombinant Antibody (AFC-TAB-H18), ADCC Enhanced | Neut, ELISA, IF, IP, FuncS, FC | Human IgG1 |
Single-domain Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-J0313-YC | Human Anti-TNFSF11 Recombinant Single Domain Antibody (HPAB-J0313-YC) | ELISA, Block | Human VHH |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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