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ID1
Transcriptional regulator (lacking a basic DNA binding domain) which negatively regulates the basic helix-loop-helix (bHLH) transcription factors by forming heterodimers and inhibiting their DNA binding and transcriptional activity. Implicated in regulating a variety of cellular processes, including cellular growth, senescence, differentiation, apoptosis, angiogenesis, and neoplastic transformation. Inhibits skeletal muscle and cardiac myocyte differentiation. Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-ARNTL/BMAL1 heterodimer (By similarity).
Protein class
Cancer-related genes, Plasma proteins, Transcription factors
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (Hepatic stellate cells, Adipocytes, Basal respiratory cells)
Immune cell specificity
Immune cell enriched (neutrophil)
Cell line specificity
Cell line enhanced (EFO-21, HaCaT, Hep G2, PC-3)
Interaction
Heterodimer with other HLH proteins. Interacts with COPS5, IFI204, GATA4 and NKX2-5 (By similarity). Interacts with CLOCK and ARNTL/BMAL1.
Molecular function
Developmental protein, Repressor
More Types Infomation
- Mouse Anti-ID1 Recombinant Antibody (clone 29D9) (MOB-3006z)
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG2a, κ
- Application: WB, ELISA, IF, IHC, IP
- Rabbit Anti-ID1 Recombinant Antibody (clone JM92-13) (MRO-0808-CN)
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- Species Reactivity: Human
- Type: Rabbit IgG
- Application: WB, IF, IHC, FC
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- Species Reactivity: Human
- Type: Mouse antibody
- Application: IHC-P, WB
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- Derivation: Phage display library
- Species Reactivity: Mouse
- Type: Rabbit IgG
- Application: WB, IHC
- Rabbit Anti-ID1 Recombinant Antibody (clone #BCH-1/#195-14); scFv Fragment (HPAB-0309-YC-S(P))
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- Species Reactivity: Human, Mouse
- Type: Rabbit scFv
- Application: ELISA, WB, IHC
- Rabbit Anti-ID1 Recombinant Antibody (clone #BCH-2/#5-3); scFv Fragment (HPAB-0307-YC-S(P))
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- Species Reactivity: Human
- Type: Rabbit scFv
- Application: ELISA, WB, IHC
- Rabbit Anti-Id1 Recombinant Antibody (clone #BCH-1/#37-2); Fab Fragment (HPAB-0418-CN-F(E))
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- Species Reactivity: Mouse
- Type: Rabbit Fab
- Application: WB, ELISA, IHC
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- Species Reactivity: Human, Mouse
- Type: Rabbit IgG
- Application: ELISA, WB, IF
- Rabbit Anti-ID1 Recombinant Antibody (clone #BCH-1/#195-14); Fab Fragment (HPAB-0309-YC-F(E))
-
- Species Reactivity: Human, Mouse
- Type: Rabbit Fab
- Application: ELISA, WB, IHC
- Rabbit Anti-ID1 Recombinant Antibody (clone #BCH-2/#5-3); Fab Fragment (HPAB-0307-YC-F(E))
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- Species Reactivity: Human
- Type: Rabbit Fab
- Application: ELISA, WB, IHC
- Rabbit Anti-Id1 Recombinant Antibody (clone #BCH-1/#37-2); scFv Fragment (HPAB-0418-CN-S(P))
-
- Species Reactivity: Mouse
- Type: Rabbit scFv
- Application: WB, ELISA, IHC
- Rabbit Anti-Id1 Recombinant Antibody (clone #BCH-1/#37-2) (HPAB-0418-CN)
-
- Species Reactivity: Mouse
- Type: Rabbit IgG
- Application: WB, ELISA, IHC
- Rabbit Anti-ID1 Recombinant Antibody (clone #BCH-1/#195-14) (HPAB-0309-YC)
-
- Species Reactivity: Human, Mouse
- Type: Rabbit IgG
- Application: ELISA, WB, IHC
- Rabbit Anti-ID1 Recombinant Antibody (clone #BCH-2/#5-3) (HPAB-0307-YC)
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- Species Reactivity: Human
- Type: Rabbit IgG
- Application: ELISA, WB, IHC
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For Research Use Only. Not For Clinical Use.