10-FnIII scaffold protein anti-Chicken Lysozyme

Name: 10-FnIII scaffold protein anti-Chicken Lysozyme
SKU: SFN-L013
Rating: 5 (1 reviews)

CAT#: SFN-L013

The tenth fibronectin type III domain (10Fn3) that bound lysozyme was isolated from the library using mRNA Display technology. The fibronectin type III domain (FN3) is a small autonomous folding unit which occurs in many animal proteins involving in ligand binding. The β-sandwich structure of FN3 closely resembles that of immunoglobulin domains. After affinity maturation, 10Fn3 variants were identified having affinities (KD=0.35 nM) for lysozyme as determined by biosensor technology. It's potential to be used in diagnostic, research and therapeutic applications.

Gene Expression

Subcellular Location and Protein Expression Figure 1 IF staining of human cell line Hep G2

Immunofluorescent staining of human cell line Hep G2 shows localization to nucleoplasm, the Golgi apparatus & actin filaments.

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/66182/1763_E3_3_selected.jpg

Normal Tissue Figure 2 IHC staining of human salivary gland

High expression. RNA expression: 21115.5 nTPM

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/48284/124814_B_3_1_val_selected.jpg

Normal Tissue Figure 3 IHC staining of human skeletal muscle

Low expression. RNA expression: 34.0 nTPM

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/48284/124814_B_3_6_val_selected.jpg

Normal Tissue Figure 4 Colon

Mucosal lymphoid cells
Staining: Low
Intensity: Moderate
Quantity: <25%

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/48284/124814_A_7_3.jpg

Normal Tissue Figure 5 Kidney

Cells in tubules
Staining: High
Intensity: Strong
Quantity: 75%-25%
Location: Cytoplasmic/membranous

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/48284/124814_A_9_5.jpg

Normal Tissue Figure 6 Testis

Leydig cells
Staining: Low
Intensity: Weak
Quantity: 75%-25%
Location: Cytoplasmic/membranous

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/55/231_A_5_6.jpg

Normal Tissue Figure 7 Lymph node

Non-germinal center cells
Staining: Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/48284/124814_A_7_8.jpg

RNA Expression Figure 8 RNA cell line category: Cell line enriched (OE19)

Cell lines ordered by descending RNA expression order.

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000090382-LYZ

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Specifications

Scaffold Name
10-FnIII

Origin
Fibronectin

Core Structure
β-sandwich of 7 β-strands

Variable Regions
2–3 loops

Target
Lysozyme

Species Reactivity
Chicken

Expression Host
E. coli

Affinity Constant
0.35 nM

Applications
ELISA; immunohistochemistry; Microscopy; Flow Cytometer; Western Blotting; Functional Study

Target

Alternative Names
Fibronectin; 10-FnIII; LYZC

Gene ID
396218

UniProt ID
P00698

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Datasheet

Datasheet - SFN-L013.pdf

MSDS

MSDS - SFN-L013.pdf

COA

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