Anti-cyCD79b (clone 10D10)-MCC-DM1 ADC
CAT#: ADC-216LZY
This ADC product is composed of an anti-cyCD79b antibody (clone 10D10) conjugated via MCC linker to DM1 (10D10-MCC-DM1). It has demonstrated a response in non-Hodgkin's lymphoma ofcynomolgus monkey treatment by a MOA (Mechanism of Action) of microtubules depolymerizing.
Gene Expression
Subcellular Location and Protein Expression
Figure 1 IF staining of human cell line REH
Immunofluorescent staining of human cell line REH shows localization to plasma membrane.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/9178/1889_C4_3_selected.jpg
Subcellular Location and Protein Expression
Figure 2 IHC staining of human lymph node
Immunohistochemical staining of human lymph node shows strong cytoplasmic positivity in lymphoid cells outside reaction centra and weak to moderate in reaction center cells.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/9178/ihc_selected.jpg
Subcellular Location and Protein Expression
Figure 3 IHC staining of human lymph node
Immunohistochemical staining of human lymph node shows distinct cytoplasmic positivity in cells of the germinal center corona.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/9751/ihc_selected.jpg
Normal Tissue
Figure 4 IF staining of human cell line A-431
Immunofluorescent staining of human cell line A-431 shows localization to Nucleoplasm &
Plasma membrane & Cytosol.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/9178/48_C6_1_blue_red_green.jpg
Normal Tissue
Figure 5 IF staining of human cell line U-2 OS
Immunofluorescent staining of human cell line U-2 OS shows localization to Nucleoplasm &
Plasma membrane & Cytosol.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/9178/47_C6_1_blue_red_green.jpg
Normal Tissue
Figure 6 Colon
Mucosal lymphoid cells
Staining:Medium
Intensity: Strong
Quantity: <25%
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/44107/169682_A_8_3.jpg
Normal Tissue
Figure 7 Lymph node
Germinal center cells
Staining:High
Intensity: Strong
Quantity: 75%-25%
Location: Cytoplasmic/membranous
Non-germinal center cells
Staining:Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/44107/169682_A_8_8.jpg
RNA Expression
Figure 8 RNA cell line category: Cell line enhanced (Daudi, REH, U-698)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000007312-CD79B
❮
❯
Specifications
- Antibody Overview
- Mouse/Human Chimeric Anti-cynomolgus monkeyCD79b mAb (10D10)
- Clone
- 10D10
- Linker
- MCC(Maleimidomethyl cyclohexane-1-carboxylate))
- Linker Class/Description
- Class: Noncleavable linker
Description: Noncleavable linker is considered noncleavable-meaning linker cleavage, and payload release does not depend on the differential properties between the plasma and some cytoplasmic compartments. Instead, the release of the cytotoxic drug is postulated to occur after internalization of the ADC via antigen-mediated endocytosis and delivery to lysosomal compartment, where the antibody is degraded to the level of amino acids through intracellular proteolytic degradation
- Drug
- DM1(N2'-deacetyl-N2'-(3-mercapto-1-oxopropyl)-maytansine)
- Drug Class/Description
- Class: Maytansinoid
Description: Maytansinoids are a group of cytotoxins structurally similar to rifamycin, geldanamycin, and ansatrienin. The eponymous natural cytotoxic agent maytansine is a 19-member lactam (ansa
macrolide) structure originally isolated from the Ethiopian shrub Maytenus ovatus. Maytansinoids can bind to tubulin at or near the vinblastine-binding site, which interfere the formation of microtubules and depolymerize already formed microtubules, inducing mitotic arrest in the intoxicated cells
Target
- Introduction
- The B lymphocyte antigen receptor is a multimeric complex that includes the antigen-specific component, surface immunoglobulin (Ig). Surface Ig non-covalently associates with two other proteins, Ig-alpha and Ig-beta, which are necessary for expression and function of the B-cell antigen receptor. This gene encodes the Ig-beta protein of the B-cell antigen component. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
- Alternative Names
- CD79B; CD79b molecule, immunoglobulin-associated beta; B29; IGB; AGM6; B-cell antigen receptor complex-associated protein beta chain; Ig-beta; B-cell-specific glycoprotein B29; immunoglobulin-associated B29 protein; CD79b antigen (immunoglobulin-associated beta);
- Gene ID
- 102145117
- UniProt ID
- G8F5R6
REVIEWS AND Q&AS
CITATIONS
RESOURCES
DOWNLOADS
RELATED PRODUCTS
Inquiry
Navs
Customer Review
There are currently no Customer reviews or questions for ADC-216LZY. Click the button above to contact us or submit your feedback about this product.
Ideal For Cross-Species Study
This chimeric anti-cynomolgus monkey CD79b antibody is perfect for our cross-species reactivity studies. The 10D10 clone binds effectively to the target, and the conjugation to DM1 allowed us to assess the efficacy of microtubule depolymerization in non-human primate cell models relevant to non-Hodgkin's lymphoma.
Stable MCC Linker Performance
The MCC linker used in this conjugate is noncleavable, which was a requirement for our study design. We needed to ensure that the release of the cytotoxic DM1 occurred only after internalization and lysosomal degradation. The product performed reliably, showing good stability and specific activity in our assays.
Q&As
-
What species reactivity does the 10D10 clone exhibit?
A: The 10D10 antibody clone is specific for cynomolgus monkey CD79b. It is a mouse/human chimeric antibody designed for research involving non-human primate models, particularly for studies related to non-Hodgkin's lymphoma in cynomolgus monkeys.
-
What is the stability of the MCC linker?
A: The MCC linker is a noncleavable linker. It is designed to be stable in the bloodstream, preventing premature release of the payload. The release of the cytotoxic drug occurs only after the ADC is internalized and degraded within the lysosomal compartment of the target cell.
View the frequently asked questions answered by Creative Biolabs Support.
Submit Your Publication
Published with our product? Submit your paper and receive a 10% discount on your next order! Share your research to earn exclusive rewards.
Related Signaling Pathways
BCR Signaling Pathway
Downloadable Resources
Download resources about recombinant antibody development and antibody engineering to boost your research.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
See other products for "CD79B"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1219z | Mouse Anti-CD79B Recombinant Antibody (clone 32B11) | ELISA, WB, FC, FuncS | Mouse IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-897 | Humanized Anti-CD79B Recombinant Antibody (TAB-897) | Neut, ELISA, IF, IP, FuncS, FC, ICC | Humanized (from mouse) IgG1, κ |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-0360MZ | Recombinant Mouse Anti-Human CD79B CD79b Molecule, Immunoglobulin-associated Beta Antibody (clone TN9) | ELISA | Mouse antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-0581 | Hi-Affi™ Rabbit Anti-CD79B Recombinant Antibody (clone DS581AB) | WB, IHC, ICC, IP, FC | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MHC-LC1918 | PE-A*02:01/Human CD79B (LLSAEPVPA) MHC Tetramer | FCM |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-027LC | Recombinant Mouse Anti-M.fascicularis CD79B Antibody | ELISA, FuncS | Mouse IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| FAMAB-0058YC | Hamster Anti-Cd79b Recombinant Antibody (clone HM79-16) | FuncS | Hamster IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| FAMAB-0058-YC-S(P) | Hamster Anti-Cd79b Recombinant Antibody (clone HM79-16); scFv Fragment | FuncS | Hamster scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| FAMAB-0058-YC-F(E) | Hamster Anti-Cd79b Recombinant Antibody (clone HM79-16); Fab Fragment | FuncS | Hamster Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0364LY | Human Anti-CD79B Recombinant Antibody (HPAB-0364LY) | Inhib, ELISA | Human IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0364LY-S(P) | Human Anti-CD79B Recombinant Antibody; scFv Fragment (HPAB-0364LY-S(P)) | Inhib, ELISA | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0364LY-F(E) | Human Anti-CD79B Recombinant Antibody; Fab Fragment (HPAB-0364LY-F(E)) | Inhib, ELISA | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-618-FY-S(P) | Human Anti-CD79B Recombinant Antibody; scFv Fragment (HPAB-618-FY-S(P)) | FC, ELISA | Humanized scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-619-FY-S(P) | Human Anti-CD79B Recombinant Antibody; scFv Fragment (HPAB-619-FY-S(P)) | FC, ELISA | Humanized scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-618-FY-F(E) | Human Anti-CD79B Recombinant Antibody; Fab Fragment (HPAB-618-FY-F(E)) | FC, ELISA | Humanized Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-619-FY-F(E) | Human Anti-CD79B Recombinant Antibody; Fab Fragment (HPAB-619-FY-F(E)) | FC, ELISA | Humanized Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AFC-TAB-897 | Afuco™ Anti-CD79B ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-897) | Neut, ELISA, IF, IP, FuncS, FC | ADCC enhanced antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-N0044-YC-S(P) | Human Anti-CD79b Recombinant Antibody; scFv Fragment (HPAB-N0044-YC-S(P)) | FuncS | Humanized scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-N0044-YC-F(E) | Human Anti-CD79b Recombinant Antibody; Fab Fragment (HPAB-N0044-YC-F(E)) | FuncS | Humanized Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0225-XY72 | CytoStream™ Mouse Anti-CD79B Recombinant Antibody (clone CB3-1) | FC | Mouse IgG1, kappa |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-FY74 | Human Anti-CD79B (clone P2C2) scFv-Fc Chimera | IA | Human IgG1, scFv-Fc |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-YC74 | Recombinant Anti-CD79B Vesicular Antibody, EV Displayed (VS-0425-YC74) | ELISA, FC, Neut, Cell-uptake |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY1222 | Anti-Mouse CD79B Immunohistochemistry Kit | IHC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0825-YC69 | SmartAb™ Recombinant Anti-CD79B pH-dependent Antibody (VS-0825-YC69) | Neut, ELISA, IF, IP, FC, ICC | Human IgG1 kappa |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-1025-YC210 | Anti-CD79B Antibody Prodrug, Protease Activated (VS-1025-YC210) | ISZ, Cyt, FuncS |
Specific Inquiry
Add to compare
See Our Custom Production in Action
Popular Products
Application: WB, IF, IP, Neut, FuncS, ELISA, FC
Application: ELISA, IP, FC, FuncS, Neut, IF, ICC
Application: ELISA, IP, FC, FuncS, Neut, IF, IHC
Application: WB, Neut, ELISA, IF, IP, FuncS, FC
Application: ELISA, FC, IP, FuncS, IF, Neut, ICC
Application: WB, ELISA, FuncS
Application: WB, ELISA, FuncS, Inhib, PK, IP, SPR
Application: ELISA, FC, Neut, Inhib
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
Send Inquiry
This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.
