Anti-cyCD79b (clone 10D10)-MCC-DM1 ADC (CAT#: ADC-216LZY)

This ADC product is composed of an anti-cyCD79b antibody (clone 10D10) conjugated via MCC linker to DM1 (10D10-MCC-DM1). It has demonstrated a response in non-Hodgkin's lymphoma ofcynomolgus monkey treatment by a MOA (Mechanism of Action) of microtubules depolymerizing.

Specific Inquiry
  • Gene Expression
  • Datasheet
  • MSDS
  • COA
Subcellular Location and Protein Expression
Normal Tissue
RNA Expression

Specifications

  • Antibody Overview
  • Mouse/Human Chimeric Anti-cynomolgus monkeyCD79b mAb (10D10)
  • Clone
  • 10D10
  • Linker
  • MCC(Maleimidomethyl cyclohexane-1-carboxylate))
  • Linker Class/Description
  • Class: Noncleavable linker
    Description: Noncleavable linker is considered noncleavable-meaning linker cleavage, and payload release does not depend on the differential properties between the plasma and some cytoplasmic compartments. Instead, the release of the cytotoxic drug is postulated to occur after internalization of the ADC via antigen-mediated endocytosis and delivery to lysosomal compartment, where the antibody is degraded to the level of amino acids through intracellular proteolytic degradation
  • Drug
  • DM1(N2'-deacetyl-N2'-(3-mercapto-1-oxopropyl)-maytansine)
  • Drug Class/Description
  • Class: Maytansinoid
    Description: Maytansinoids are a group of cytotoxins structurally similar to rifamycin, geldanamycin, and ansatrienin. The eponymous natural cytotoxic agent maytansine is a 19-member lactam (ansa
    macrolide) structure originally isolated from the Ethiopian shrub Maytenus ovatus. Maytansinoids can bind to tubulin at or near the vinblastine-binding site, which interfere the formation of microtubules and depolymerize already formed microtubules, inducing mitotic arrest in the intoxicated cells

Target

  • Introduction
  • The B lymphocyte antigen receptor is a multimeric complex that includes the antigen-specific component, surface immunoglobulin (Ig). Surface Ig non-covalently associates with two other proteins, Ig-alpha and Ig-beta, which are necessary for expression and function of the B-cell antigen receptor. This gene encodes the Ig-beta protein of the B-cell antigen component. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
  • Alternative Names
  • CD79B; CD79b molecule, immunoglobulin-associated beta; B29; IGB; AGM6; B-cell antigen receptor complex-associated protein beta chain; Ig-beta; B-cell-specific glycoprotein B29; immunoglobulin-associated B29 protein; CD79b antigen (immunoglobulin-associated beta);

Related Resources

  • Related Signaling Pathways

Downloads

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For Research Use Only. Not For Clinical Use.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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