Anti-CD133 (AC133)-vcMMAF ADC (CAT#: ADC-014LCT)

• Antibody Overview
• Murine Anti-Human CD133 Antibody (AC133)

• Clone
• AC133

• Linker
• VC (valine-citrulline)

• Linker Class/Description
• Peptide linkers, belonging to Enzymatically cleavable linkers, combine greater systemic stability with rapid enzymatic release of the drug in the target cell. The scission of peptidic bonds relies on lysosomal proteolytic enzymes, which have very low activities in blood due to endogenous inhibitors and the unfavorably high pH value of blood.

• Drug
• MMAF (Monomethyl auristatin F)

• Drug Class/Description
• Auristatins are water-soluble dolastatin analogs of dolastatin 10. Dolastatin 10 belongs to dolastatin family and it can powerfully bind to tubulin, thus inhibiting polymerization mediated through the binding to the vinca alkaloid binding domain, and causes cell to accumulate in metaphase arrest.

• Introduction
• This gene encodes a pentaspan transmembrane glycoprotein. The protein localizes to membrane protrusions and is often expressed on adult stem cells, where it is thought to function in maintaining stem cell properties by suppressing differentiation. Mutations in this gene have been shown to result in retinitis pigmentosa and Stargardt disease. Expression of this gene is also associated with several types of cancer. This gene is expressed from at least five alternative promoters that are expressed in a tissue-dependent manner. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]

• Alternative Names
• PROM1; prominin 1; RP41; AC133; CD133; MCDR2; STGD4; CORD12; PROML1; MSTP061; prominin-1; hProminin; antigen AC133; prominin-like protein 1; hematopoietic stem cell antigen;

• Gene ID
• 8842

• UniProt ID
• O43490

• TAB-1074CL
• Anti-Human PROM1 Recombinant Antibody (AC133)

• TAB-1074CL-S(P)
• Anti-Human PROM1 Recombinant Antibody scFv Fragment (AC133)

• TAB-1074CL-F(E)
• Anti-Human PROM1 Recombinant Antibody Fab Fragment (AC133)

• VS-1024-FY265
• Anti-PROM1 (clone AC133) Recombinant Antibody Coupled Liposome (VS-1024-FY265)

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