Anti-PROM1 (clone AC133) Recombinant Antibody Coupled Liposome (VS-1024-FY265)
CAT#: VS-1024-FY265
Anti-PROM1 Antibody Liposome is a specialized drug delivery system designed to target and bind to the PROM1 (also known as CD133) protein, which is a marker for cancer stem cells and other stem cell populations. The liposomes are encapsulated with anti-PROM1 antibodies, allowing for targeted delivery of therapeutic agents directly to cells expressing this marker.
Gene Expression
Normal Tissue
Figure 1 Colon
Goblet cells
Staining:Medium
Intensity: Moderate
Quantity:>75%
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/4922/15212_A_8_3.jpg
Normal Tissue
Figure 2 Liver
Cholangiocytes
Staining:High
Intensity: Strong
Quantity: 75%-25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/4922/15212_A_7_4.jpg
Normal Tissue
Figure 3 Pancreas
Exocrine glandular cells
Staining:Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/4922/15212_A_2_3.jpg
Normal Tissue
Figure 4 Kidney
Bowman's capsule
Staining:High
Intensity: Strong
Quantity:>75%
Distal tubules
Staining:Medium
Intensity: Moderate
Quantity: 75%-25%
Proximal tubules (cell body)
Staining:Medium
Intensity: Strong
Quantity: <25%
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/4922/15212_A_8_5.jpg
RNA Expression
Figure 5 RNA cell line category: Cell line enhanced (AF22, CACO-2, CAPAN-2, EFO-21, NTERA-2, RPTEC TERT1)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000007062-PROM1
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More Infomation
Specifications
- Potential Clinical Applications
- The immunoliposomes was designed to encapsulate gemcitabine, target glioblastoma stem cells.
Product Composition
- Clone
- AC133
- Antibody Type
- IgG
- Antibody Host
- Mouse
- Antibody Reactivity
- Human
- Antibody Description
- This is a human anti-HER2 antibody. HER2 antibody is a type of antibody that targets the human epidermal growth factor receptor 2 (HER2), which is a protein that promotes the growth of cancer cells.
Product Property
- Storage
- See in the COA
- Storage Shelf Time
- See in the COA
Target Information
- Target
- PROM1
- Introduction
- CD133 antigen, also known as prominin-1, is a glycoprotein encoded by the PROM1 gene in humans. It is a member of pentaspan transmembrane glycoprotein, which is specifically located in the cell protrusion. When embedded in the cell membrane, the membrane topology of prominin-1 extends the N-terminus into the extracellular space, while the C-terminus is located in the intracellular compartment. The protein is composed of five transmembrane fragments, of which the first and second fragments and the third and fourth fragments are connected by an intracellular loop, and the second and third and fourth and fifth and transmembrane fragments are by an extracellular loop Connected.
- Alternative Names
- PROM1; AC133; CD133; CORD12; MCDR2; MSTP061; PROML1; RP41; STGD4; prominin 1
- Full Name
- prominin-1
- Gene ID
- 8842
- UniProt ID
- O43490
- Sequence Similarities
- Belongs to the prominin family.
- Cellular Localization
- Cell membrane, Cell projection, Cilium, Endoplasmic reticulum, Membrane
- Post Translation Modifications
- Isoform 1 and isoform 2 are glycosylated.
Acetylation at Lys-225, Lys-257 and Lys-264 by NAT8 and NAT8B may control PROM1 protein expression and its function in cell apoptosis.
- Protein Refseq
- NP_001139319.1; NP_001139320.1; NP_001139321.1
- Function
- May play a role in cell differentiation, proliferation and apoptosis (PubMed:24556617).
Binds cholesterol in cholesterol-containing plasma membrane microdomains and may play a role in the organization of the apical plasma membrane in epithelial cells. During early retinal development acts as a key regulator of disk morphogenesis. Involved in regulation of MAPK and Akt signaling pathways. In neuroblastoma cells suppresses cell differentiation such as neurite outgrowth in a RET-dependent manner (PubMed:20818439).
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Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
See other products for "Clone AC133"
- CAT
- Product Name
See other products for "PROM1"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1990z | Mouse Anti-PROM1 Recombinant Antibody (clone 41D7) | WB, FC, IHC | Mouse IgG1 |
| MRO-1733-CN | Rabbit Anti-PROM1 Polyclonal Antibody (MRO-1733-CN) | WB, IF, IHC, FC | Rabbit IgG |
| VS4-CJ93 | Recombinant Human Anti-PROM1 Antibody (clone 5F5) | ELISA | Human IgG1 |
| VS7-0425-WR693 | Mouse Anti-PROM1 Recombinant Antibody (clone 2F8C5) | FC | Mouse IgG1 |
| VS7-0425-WR694 | Mouse Anti-PROM1 Monoclonal Antibody (VS7-0425-WR694) | IHC-P, IF, FC, ELISA | Mouse IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| IAB-B028(A) | Recombinant Anti-human PROM1 Intrabody [(D-Arg)9] | ELISA, Neut, FuncS | scFv-(D-Arg)9 |
| IAB-B028(G) | Recombinant Anti-human PROM1 Intrabody [+36 GFP] | PCA, WB, FuncS | scFv-(+36GFP) |
| IAB-B028(T) | Recombinant Anti-human PROM1 Intrabody [Tat] | FACS, ELISA, IF, FuncS | scFv-Tat |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AGTO-G057S | Anti-PROM1 immunotoxin (scFv)-Sap | Cytotoxicity assay, Function study |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-1074CL | Anti-Human PROM1 Recombinant Antibody (AC133) | ELISA, ICC, IB | |
| TAB-1075CL | Mouse Anti-PROM1 Recombinant Antibody (TAB-1075CL) | WB, IF, FC, IHC | Mouse IgG |
| TAB-1074CL-S(P) | Anti-Human PROM1 Recombinant Antibody scFv Fragment (AC133) | ELISA | |
| TAB-1075CL-S(P) | Mouse Anti-PROM1 Recombinant Antibody; scFv Fragment (TAB-1075CL-S(P)) | WB, IF, FC | Mouse scFv |
| TAB-0375CL-F(E) | Anti-Mouse PROM1 Recombinant Antibody Fab Fragment (293AC1C3H9) | FC | Chimeric (mouse/human) |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0183-YC-S(P) | Human Anti-PROM1 Recombinant Antibody (clone h133H/h133La); scFv Fragment | ELISA, FC | Humanized scFv |
| HPAB-0088-FY-S(P) | Human Anti-PROM1 Recombinant Antibody; scFv Fragment (HPAB-0088-FY-S(P)) | FC | Human scFv |
| HPAB-1396-FY-F(E) | Human Anti-PROM1 Recombinant Antibody (clone H133); scFv Fragment | FC | Humanized scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0183-YC-F(E) | Human Anti-PROM1 Recombinant Antibody (clone h133H/h133La); Fab Fragment | ELISA, FC | Humanized Fab |
| HPAB-0088-FY-F(E) | Human Anti-PROM1 Recombinant Antibody; Fab Fragment (HPAB-0088-FY-F(E)) | FC | Human Fab |
| HPAB-1396-FY-S(P) | Human Anti-PROM1 Recombinant Antibody (clone H133); Fab Fragment | FC | Humanized Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NS-019CN | Mouse Anti-PROM1 Recombinant Antibody (NS-019CN) | ELISA, IF, IHC, FC | Mouse IgG |
| NS-019CN-F(E) | Mouse Anti-PROM1 Recombinant Antibody; Fab Fragment (NS-019CN-F(E)) | ELISA, IF, IHC, FC | Mouse Fab |
| NS-019CN-S(P) | Mouse Anti-PROM1 Recombinant Antibody; scFv Fragment (NS-019CN-S(P)) | ELISA, IF, IHC, FC | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MHC-CN1161 | PE-A*02:01/Human PROM1 (YLQWIEFSI) MHC Tetramer | FCM, IHC | |
| MHC-CN1162 | APC-A*02:01/Human PROM1 (YLQWIEFSI) MHC Tetramer | FCM, IHC | |
| MHC-CN1163 | FITC-A*02:01/Human PROM1 (YLQWIEFSI) MHC Tetramer | FCM, IHC | |
| MHC-CN1164 | A*02:01/Human PROM1 (YLQWIEFSI) MHC Tetramer | FCM, IHC | |
| MHC-YF689 | A*02:01/Human Prominin1 (YLQWIEFSI) MHC Pentamer | FCM |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-0060-FY | Rabbit Anti-PROM1 Recombinant Antibody (clone AFY0031) | IF, IHC-P, WB | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0924-YC86 | Mouse Anti-PROM1 Recombinant Antibody (VS-0924-YC86) - Cancer Stem Cell Marker | IHC, WB | Mouse IgG1 |
| VS-0924-YC87 | Rabbit Anti-PROM1 Antibody (VS-0924-YC87) - Cancer Stem Cell Marker | IHC, WB | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0225-XY181 | CytoStream™ Mouse Anti-PROM1 Recombinant Antibody (clone 293C3) | FC | Mouse IgG2b, kappa |
| VS-0225-XY182 | CytoStream™ Mouse Anti-PROM1 Recombinant Antibody (VS-0225-XY182) | FC | Mouse IgG1, kappa |
| VS13-YC944 | CytoStream™ Mouse Anti-PROM1 Recombinant Antibody (VS13-YC944) | WB, IHC-P, FC | Mouse IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-YC266 | Recombinant Anti-PROM1 Vesicular Antibody, EV Displayed (VS-0425-YC266) | ELISA, FC, Cell-uptake |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY5735 | Anti-PROM1 Immunohistochemistry Kit | IHC |
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