Ankyrin repeat scaffold protein anti-Human IL4
CAT#: SAR-L261
The Ankyrin repeat that bound IL4 was isolated from the library using ribosome display techonology. The ankyrin repeat is a 33-residue motif in proteins consisting of two alpha helices separated by loops, first discovered in signaling proteins in yeast Cdc10 and Drosophila Notch. Domains consisting of ankyrin repeats mediate protein–protein interactions and are among the most common structural motifs in known proteins. After affinity maturation, Ankyrin repeat variants were identified having affinities (KD=9.0 pM) for IL4 as determined by biosensor technology. It's potential to be used in diagnostic, research and therapeutic applications.
Gene Expression
Normal Tissue
Figure 1 Testis
Leydig cells
Staining:Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/78477/168090_A_5_6.jpg
RNA Expression
Figure 2 RNA cell line category: Cell line enriched (MOLT-4)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000113520-IL4
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Specifications
- Scaffold Name
- Ankyrin repeat
- Origin
- Ankyrin repeat proteins
- Core Structure
- 2α-helices, β-turn
- Variable Regions
- b-turn,1a-helix and loop
- Target
- IL4
- Species Reactivity
- Human
- Expression Host
- BL21 (DE3) cells
- Affinity Constant
- 9.0 pM
- Applications
- ELISA; IHC; Microscopy; FC; WB; FuncS
Target
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Related Diseases
Asthma
Autoimmune Thyroid Disease
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| CAT | Product Name | Application | Type |
|---|---|---|---|
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