Human Anti-IL4 scFv-Fc Chimera (VS-0425-FY131) (CAT#: VS-0425-FY131)

• Immunogen
• Using human IL4 as an immunogen.

• Host Species
• Human

• Type
• Human IgG1, scFv-Fc

• Specificity
• Human IL4

• Species Reactivity
• Human

• Applications
• ELISA, Inhibition

• Related Disease
• Schistosomiasis and Allergic Disease

• Purity
• >95% as determined by SDS-PAGE

• Concentration
• Please refer to the vial label for the specific concentration.

• Storage
• Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

• Shipping
• Ice packs

• Application Notes
• The optimal dilution concentration is determined by the experiment.

• Alternative Names
• Interleukin 4

• Gene ID
• 3565

• UniProt ID
• P05112

• Long Name
• Interleukin 4

• Sequence Similarities
• Belongs to the IL-4/IL-13 family.

• Cellular Localization
• Secreted

• Post Translation Modifications
• Glycosylation at Asn62
  Modification sites at PhosphoSitePlus
  Glycosylation from GlyGen 1 site

• Protein Refseq
• NP_000580.1; NP_001341919.1; NP_758858.1

• Function
• Cytokine secreted primarily by mast cells, T-cells, eosinophils, and basophils that plays a role in regulating antibody production, hematopoiesis and inflammation, and the development of effector T-cell responses.
  Induces the expression of class II MHC molecules on resting B-cells.
  Enhances both secretion and cell surface expression of IgE and IgG1.
  Regulates also the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes.
  Positively regulates IL31RA expression in macrophages.
  Stimulates autophagy in dendritic cells by interfering with mTORC1 signaling and through the induction of RUFY4.
  In addition, plays a critical role in higher functions of the normal brain, such as memory and learning.
  Upon binding to IL4, IL4R receptor dimerizes either with the common IL2R gamma chain/IL2RG to produce the type 1 signaling complex, located mainly on hematopoietic cells, or with the IL13RA1 to produce the type 2 complex, which is expressed also on nonhematopoietic cells.

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