Human Anti-IL4 scFv-Fc Chimera (VS-0425-FY131)
CAT#: VS-0425-FY131
The anti-IL4 scFv-FC is a targeted biologic that binds to interleukin-4 (IL-4), a critical cytokine in the regulation of immune responses and allergic inflammation, with the objective of neutralizing its effects to manage conditions like asthma and other allergic diseases.
Gene Expression
Normal Tissue
Figure 1 Testis
Leydig cells
Staining:Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/78477/168090_A_5_6.jpg
RNA Expression
Figure 2 RNA cell line category: Cell line enriched (MOLT-4)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000113520-IL4
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Specifications
- Immunogen
- Using human IL4 as an immunogen.
- Host Species
- Human
- Type
- Human IgG1, scFv-Fc
- Specificity
- Human IL4
- Species Reactivity
- Human
- Applications
- ELISA, Inhibition
- Related Disease
- Schistosomiasis and Allergic Disease
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- The optimal dilution concentration is determined by the experiment.
Target
- Alternative Names
- Interleukin 4
- Gene ID
- 3565
- UniProt ID
- P05112
- Long Name
- Interleukin 4
- Sequence Similarities
- Belongs to the IL-4/IL-13 family.
- Cellular Localization
- Secreted
- Post Translation Modifications
- Glycosylation at Asn62
Modification sites at PhosphoSitePlus
Glycosylation from GlyGen 1 site
- Protein Refseq
- NP_000580.1; NP_001341919.1; NP_758858.1
- Function
- Cytokine secreted primarily by mast cells, T-cells, eosinophils, and basophils that plays a role in regulating antibody production, hematopoiesis and inflammation, and the development of effector T-cell responses.
Induces the expression of class II MHC molecules on resting B-cells.
Enhances both secretion and cell surface expression of IgE and IgG1.
Regulates also the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes.
Positively regulates IL31RA expression in macrophages.
Stimulates autophagy in dendritic cells by interfering with mTORC1 signaling and through the induction of RUFY4.
In addition, plays a critical role in higher functions of the normal brain, such as memory and learning.
Upon binding to IL4, IL4R receptor dimerizes either with the common IL2R gamma chain/IL2RG to produce the type 1 signaling complex, located mainly on hematopoietic cells, or with the IL13RA1 to produce the type 2 complex, which is expressed also on nonhematopoietic cells.
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Related Diseases
Asthma
Autoimmune Thyroid Disease
Downloadable Resources
Download resources about recombinant antibody development and antibody engineering to boost your research.
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-221 | Anti-Human IL4 Recombinant Antibody (TAB-221) | WB, ELISA, FC, IP, FuncS, IF, Neut | IgG1 - kappa |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-666LC | Anti-human IL4 Recombinant Antibody (6A1) (TAB-666LC) | ELISA, FC | |
| TAB-666LC-S(P) | Anti-human IL4 scFv Fragment (6A1) | ELISA, FC | |
| TAB-666LC-F(E) | Anti-human IL4 Fab Fragment (6A1) | ELISA, FC | |
| MOB-0341MC | Recombinant Mouse Anti-IL4 Antibody | WB, Neut |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-667LC | Human Anti-IL4 Recombinant Antibody (TAB-667LC) | ELISA, FC | Human IgG1 |
| TAB-667LC-S(P) | Human Anti-IL4 Recombinant Antibody; scFv Fragment (TAB-667LC-S(P)) | ELISA, FC | Human scFv |
| TAB-667LC-F(E) | Human Anti-IL4 Recombinant Antibody; Fab Fragment (TAB-667LC-F(E)) | ELISA, FC | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-1403CQ | Rat Anti-IL4 Recombinant Antibody (clone 25D2), Biotin | Block, ELISA, IHC, WB | Rat IgG1 |
| NEUT-1420CQ | Rat Anti-Il4 Recombinant Antibody (NEUT-1420CQ) | Block, DB | Rat IgG1 |
| NEUT-1428CQ | Rat Anti-Il4 Recombinant Antibody (clone 1D11) | Block, ELISA, FC, ICC, IF, WB | Rat IgG2b |
| NEUT-1429CQ | Rat Anti-Il4 Recombinant Antibody (clone 24G2) | Block, ELISA, ICC, IF, IHC, WB | Rat IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-1424CQ | Rat Anti-Il4 Recombinant Antibody (clone CBL238) | ELISA, Neut | Rat IgG2b |
| NEUT-1425CQ | Rat Anti-Il4 Recombinant Antibody (clone CBL899) | ELISA, FC, IF, Neut, WB | Rat IgG2b, κ |
| NEUT-1426CQ | Rat Anti-Il4 Recombinant Antibody (clone CBL993) | Neut, ELISA | Rat IgG1 |
| NEUT-1427CQ | Rat Anti-Il4 Recombinant Antibody (clone 11B11) | ELISA, CyTOF, ELISPOT, Neut, ICC, IP, IHC | Rat IgG1, κ |
| NEUT-1430CQ | Mouse Anti-IL4 Recombinant Antibody (clone CBL606) | Neut | Mouse IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-1812 | Rabbit Anti-IL4 Recombinant Antibody (clone DS1812AB) | ICC, WB | Rabbit IgG |
| MOR-4273 | Rabbit Anti-IL4 Recombinant Antibody (clone SI356DS) | ELISA | Rabbit IgG |
| MOR-4621 | Rabbit Anti-Il4 Recombinant Antibody (clone TH134DS) | WB | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0079-YC | Mouse Anti-IL4 Recombinant Antibody (clone m3B9) | ELISA | Mouse IgG |
| HPAB-0080-YC | Human Anti-IL4 Recombinant Antibody (clone hu3B9) | ELISA | Humanized IgG, κ |
| HPAB-0081-YC | Mouse Anti-IL4 Recombinant Antibody (clone m19C11) | Block, FuncS | Mouse IgG |
| HPAB-0082-YC | Human Anti-IL4 Recombinant Antibody (clone hu19C11) | ELISA | Humanized IgG, κ |
| MRO-0832-CN | Rabbit Anti-IL4 Recombinant Antibody (clone JA86-10) | WB, IF, IHC | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0079-YC-S(P) | Mouse Anti-IL4 Recombinant Antibody (clone m3B9); scFv Fragment | ELISA | Mouse scFv |
| HPAB-0080-YC-S(P) | Human Anti-IL4 Recombinant Antibody (clone hu3B9); scFv Fragment | ELISA | Humanized scFv |
| HPAB-1537WJ-S(P) | Human Anti-IL4 Recombinant Antibody; scFv Fragment (clone h25D2-9) | ELISA, WB, Neut | Human scFv |
| HPAB-1539WJ-S(P) | Mouse Anti-IL4 Recombinant Antibody; scFv Fragment (clone 3B9) | ELISA, WB, FC | Mouse scFv |
| HPAB-1540WJ-S(P) | Human Anti-IL4 Recombinant Antibody; scFv Fragment (clone ch3B9) | ELISA, WB, FC | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0079-YC-F(E) | Mouse Anti-IL4 Recombinant Antibody (clone m3B9); Fab Fragment | ELISA | Mouse Fab |
| HPAB-0080-YC-F(E) | Human Anti-IL4 Recombinant Antibody (clone hu3B9); Fab Fragment | ELISA | Humanized Fab |
| HPAB-0081-YC-F(E) | Mouse Anti-IL4 Recombinant Antibody (clone m19C11); Fab Fragment | Block, FuncS | Mouse Fab |
| HPAB-0082-YC-F(E) | Human Anti-IL4 Recombinant Antibody (clone hu19C11); Fab Fragment | ELISA | Humanized Fab |
| HPAB-1537WJ-F(E) | Human Anti-IL4 Recombinant Antibody; Fab Fragment (clone h25D2-9) | ELISA, WB, Neut | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AFC-TAB-221 | Afuco™ Anti-IL4 ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-221) | ELISA, FC, IP, FuncS, IF | ADCC enhanced antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS3-WK1322 | Mouse Anti-IL4 Recombinant Antibody (VS3-WK1322) | ELISA, WB | Mouse IgM |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0225-XY141 | CytoStream™ Rat Anti-IL4 Recombinant Antibody (clone 11B11) | FC | Rat IgG1 |
| VS-0225-XY142 | CytoStream™ Mouse Anti-IL4 Recombinant Antibody (VS-0225-XY142) | ELISA, FC | Mouse IgG1, kappa |
| VS-0225-XY143 | CytoStream™ Rat Anti-IL4 Recombinant Antibody (VS-0225-XY143) | ELISA, FC, Neut, WB | Rat IgG2b |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY3531 | Anti-Mouse IL4 Immunohistochemistry Kit | IHC |
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