Recombinant Anti-human Aβ42 Intrabody [Tat] (CAT#: IAB-B042(T))

• Immunogen
• human Amyloid β Peptide 42

• Host Species
• human

• Type
• scFv-Tat

• Cell Penetrating Peptide
• TAT
  TAT was able to deliver different proteins, such as horseradish peroxidase and RNase A across cell membrane into the cytoplasm in different cell lines in vitro. The size range of proteins with effective delivery is from 30kDa to 120-150kDa. In one study, TAT-fused proteins are rapidly internalized by lipid raft−dependent macropinocytosis using a transducible TAT−Cre recombinase reporter assay on live cells. In another study, a TAT-fused protein was delivered into mitochondria of breast cancer cells and decreased the survival of breast cancer cells, which showed capability of TAT-fusion proteins to modulate mitochondrial function and cell survival. However, very few in vivo studies have succeeded. In one study, in vivo delivery of TAT- or penetratin-crosslinked Fab fragments yielded varied organ distributions and an overall increase in organ retention, which showed tissue localization.

• Species Reactivity
• human

• Applications
• Can be useful in applications such as: Enzyme-linked Immunosorbent Assay; Neutralization; Functional studies

• Purity
• >95% as determined by Analysis by RP-HPLC & analysis by SDS-PAGE

• Storage
• Store at – 20 or -70°C upon receipt. Divide antibody into aliquots prior usage and avoid multiple freeze-thaw cycles.

• Alternative Names
• Aβ42; Amyloid β Peptide 42

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