This product is a mouse antibody specific for the peptide Aβ42 N-terminal epitope, with Aβ42 peptide binding and strong, and can significantly promote phagocytosis of microglia Aβ42 peptide was dissolved and clear Aβ deposition.
Figure 1 3F5 inhibits the neuronal cell apoptosis induced by Aβ1–42 fibrils.
The percentage of cell apoptosis on SH-SY5Y cells stained with AnnexinV-FITC/PI. The experiments were repeated three times.
Xing, H. Y., Li, B., Peng, D., Wang, C. Y., Wang, G. Y., Li, P., ... & Chen, J. H. (2017). A novel monoclonal antibody against the N-terminus of Aβ1-42 reduces plaques and improves cognition in a mouse model of Alzheimer’s disease. PloS one, 12(6), e0180076.
Figure 2 3F5 specifically binds the N-terminus of Aβ1–42.
Aβ1–42 (0–1 μg/mL) without FITC conjugation was preincubated with 3F5 overnight at 4˚C. Thereafter, Aβ1–42 (0–1 μg/mL) without FITC conjugation and Aβ1–42 coated on ELISA plates competitively bound with 3F5 for 90 min at 37˚C. The competitive binding of 3F5 with free or coated Aβ1–42 was detected by ELISA.
Xing, H. Y., Li, B., Peng, D., Wang, C. Y., Wang, G. Y., Li, P., ... & Chen, J. H. (2017). A novel monoclonal antibody against the N-terminus of Aβ1-42 reduces plaques and improves cognition in a mouse model of Alzheimer’s disease. PloS one, 12(6), e0180076.
Figure 3 SH-SY5Y cell images were shown by microscopy (100×).
Xing, H. Y., Li, B., Peng, D., Wang, C. Y., Wang, G. Y., Li, P., ... & Chen, J. H. (2017). A novel monoclonal antibody against the N-terminus of Aβ1-42 reduces plaques and improves cognition in a mouse model of Alzheimer’s disease. PloS one, 12(6), e0180076.
Figure 4 3F5 reduces the neurotoxicity of Aβ1–42 fibrils in vitro.
Xing, H. Y., Li, B., Peng, D., Wang, C. Y., Wang, G. Y., Li, P., ... & Chen, J. H. (2017). A novel monoclonal antibody against the N-terminus of Aβ1-42 reduces plaques and improves cognition in a mouse model of Alzheimer’s disease. PloS one, 12(6), e0180076.
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
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CAT | Product Name | Application | Type |
---|---|---|---|
MOB-25 | Recombinant Anti-human Aβ42 Antibody | WB, FC, FuncS | IgG |
MHH-25 | Recombinant Human Anti-human Aβ42 Antibody | FC, WB, FuncS | IgG |
FAMAB-0160-CN | Human Anti-Aβ42 Recombinant Antibody (clone scFv59) | WB, ELISA, IF, IHC | Human IgG |
HPAB-0586-FY | Human Anti-Aβ42 Recombinant Antibody (clone M06) | DB, ELISA | Human IgG |
HPAB-2064-FY | Human Anti-Aβ42 Recombinant Antibody (clone 8F5) | Neut, ELISA, DB, IF | Human IgG |
CAT | Product Name | Application | Type |
---|---|---|---|
MOB-25-F(E) | Recombinant Anti-human Aβ42 Antibody Fab Fragment | Neut, IF, FuncS | Fab |
MHH-25-F(E) | Recombinant Human Anti-human Aβ42 Antibody Fab Fragment | IF, FC, Biosensors, FuncS | Fab |
FAMAB-0160-CN-F(E) | Human Anti-Aβ42 Recombinant Antibody (clone scFv59); Fab Fragment | WB, ELISA, IF, IHC | Human Fab |
HPAB-0511-WJ-F(E) | Mouse Anti-Aβ42 Recombinant Antibody (clone 3F5); Fab Fragment | ELISA, FC | Mouse Fab |
HPAB-2064-FY-F(E) | Human Anti-Aβ42 Recombinant Antibody (clone 8F5); Fab Fragment | Neut, ELISA | Human Fab |
CAT | Product Name | Application | Type |
---|---|---|---|
MOB-25-S(P) | Recombinant Anti-human Aβ42 Antibody scFv Fragment | WB, FC, FuncS | scFv |
MHH-25-S(P) | Recombinant Human Anti-human Aβ42 Antibody scFv Fragment | Neut, WB, FuncS | scFv |
HPAB-0511-WJ-S(P) | Mouse Anti-Aβ42 Recombinant Antibody (clone 3F5); scFv Fragment | ELISA, FC | Mouse scFv |
HPAB-0586-FY-S(P) | Human Anti-Aβ42 Recombinant Antibody (clone M06); scFv Fragment | DB, ELISA | Human scFv |
HPAB-2064-FY-S(P) | Human Anti-Aβ42 Recombinant Antibody (clone 8F5); scFv Fragment | Neut, ELISA | Human scFv |
CAT | Product Name | Application | Type |
---|---|---|---|
IAB-B042(A) | Recombinant Anti-human Aβ42 Intrabody [(D-Arg)9] | CO-IP, FuncS | scFv-(D-Arg)9 |
IAB-B042(G) | Recombinant Anti-human Aβ42 Intrabody [+36 GFP] | ELISA, IF, Neut, FuncS | scFv-(+36GFP) |
IAB-B042(T) | Recombinant Anti-human Aβ42 Intrabody [Tat] | ELISA, Neut, FuncS | scFv-Tat |
CAT | Product Name | Application | Type |
---|---|---|---|
HPAB-2023-FY-VHH | Camelid Anti-Aβ42 Recombinant Single Domain Antibody (clone VHH07) | ELISA | Llama VHH |
HPAB-2024-FY-VHH | Camelid Anti-Aβ42 Recombinant Single Domain Antibody (clone VHH05) | ELISA | Llama VHH |
HPAB-2025-FY-VHH | Camelid Anti-Aβ42 Recombinant Single Domain Antibody (clone VHH03) | ELISA | Llama VHH |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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