Human Anti-Aβ42 (clone 8F5) scFv-Fc Chimera (CAT#: VS-0325-FY167)

• Immunogen
• Human A-beta oligomer antigen (1-42).

• Host Species
• Human

• Type
• Human IgG1, scFv-Fc

• Specificity
• Human Aβ42

• Species Reactivity
• Human

• Clone
• 8F5

• Applications
• Neutralization, ELISA, Dot Blot

• Related Disease
• Alzheimer's disease

• Purity
• >95% as determined by SDS-PAGE

• Concentration
• Please refer to the vial label for the specific concentration.

• Storage
• Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

• Shipping
• Ice packs

• Alternative Names
• Aβ42; Human Amyloid beta 42

• UniProt ID
• P05067

• Long Name
• Human Amyloid beta 42

• Sequence Similarities
• Belongs to the APP family.

• Cellular Localization
• Cell membrane; Membrane; Perikaryon; Cell projection, growth cone; Membrane, clathrin-coated pit; Early endosome; Cytoplasmic vesicle

• Post Translation Modifications
• Proteolytically processed under normal cellular conditions.
  Proteolytically cleaved by caspases during neuronal apoptosis.
  N-glycosylated
  Phosphorylation in the C-terminal on tyrosine, threonine and serine residues is neuron-specific
  Extracellular binding and reduction of copper, results in a corresponding oxidation of Cys-144 and Cys-158, and the formation of a disulfide bond.
  Trophic-factor deprivation triggers the cleavage of surface APP by beta-secretase to release sAPP-beta which is further cleaved to release an N-terminal fragment of APP.
  Amyloid-beta peptides are degraded by IDE.
  Sulfated on tyrosine residues.
  Glycosylation at Thr107, Thr381, Thr352, Thr353, Thr366, Thr367, Ser370, Thr371, Asn542, Asn571, Thr600, Thr633, Thr651, Thr652, Ser656, Thr659, Thr663, Ser667, and Tyr681
  Ubiquitination at Lys751 and Lys763
  Modification sites at PhosphoSitePlus
  Glycosylation from Gly
  Glycosylation from GlyGen 26 sites, 4 N-linked glycans (1 site), 5 O-linked glycans (22 sites)

• Function
• Human Aβ42 (Amyloid-beta 42) is a peptide fragment of the amyloid precursor protein, implicated in the pathogenesis of Alzheimer's disease. Its aggregation and accumulation in the brain contribute to the formation of amyloid plaques, a hallmark of the disease.

Isotype Control

• MOB-200CQ
• Human IgG Fc Isotype Control Antibody

Secondary Antibody

• 2ND-029CQ
• Goat Anti-Human IgG Fc Antibody

• HPAB-2064-FY
• Human Anti-Aβ42 Recombinant Antibody (clone 8F5)

• HPAB-2064-FY-F(E)
• Human Anti-Aβ42 Recombinant Antibody (clone 8F5); Fab Fragment

• HPAB-2064-FY-S(P)
• Human Anti-Aβ42 Recombinant Antibody (clone 8F5); scFv Fragment

Select a product category from the dropdown menu below to view related products.