Human Anti-Aβ42 (clone 8F5) scFv-Fc Chimera
CAT#: VS-0325-FY167
Anti-Aβ42 scFv-Fc is an antibody that binds to amyloid-beta (Aβ) in the brain. It can be used to study the structure of Aβ fibrils and to inhibit the formation of Aβ amyloid fibrils. These antibodies could potentially be used in research related to Alzheimer's disease and antibody engineering.
Specifications
- Immunogen
- Human A-beta oligomer antigen (1-42).
- Host Species
- Human
- Type
- Human IgG1, scFv-Fc
- Specificity
- Human Aβ42
- Species Reactivity
- Human
- Clone
- 8F5
- Applications
- Neutralization, ELISA, Dot Blot
- Related Disease
- Alzheimer's disease
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Target
- Alternative Names
- Aβ42; Human Amyloid beta 42
- UniProt ID
- P05067
- Long Name
- Human Amyloid beta 42
- Sequence Similarities
- Belongs to the APP family.
- Cellular Localization
- Cell membrane; Membrane; Perikaryon; Cell projection, growth cone; Membrane, clathrin-coated pit; Early endosome; Cytoplasmic vesicle
- Post Translation Modifications
- Proteolytically processed under normal cellular conditions.
Proteolytically cleaved by caspases during neuronal apoptosis.
N-glycosylated
Phosphorylation in the C-terminal on tyrosine, threonine and serine residues is neuron-specific
Extracellular binding and reduction of copper, results in a corresponding oxidation of Cys-144 and Cys-158, and the formation of a disulfide bond.
Trophic-factor deprivation triggers the cleavage of surface APP by beta-secretase to release sAPP-beta which is further cleaved to release an N-terminal fragment of APP.
Amyloid-beta peptides are degraded by IDE.
Sulfated on tyrosine residues.
Glycosylation at Thr107, Thr381, Thr352, Thr353, Thr366, Thr367, Ser370, Thr371, Asn542, Asn571, Thr600, Thr633, Thr651, Thr652, Ser656, Thr659, Thr663, Ser667, and Tyr681
Ubiquitination at Lys751 and Lys763
Modification sites at PhosphoSitePlus
Glycosylation from Gly
Glycosylation from GlyGen 26 sites, 4 N-linked glycans (1 site), 5 O-linked glycans (22 sites)
- Function
- Human Aβ42 (Amyloid-beta 42) is a peptide fragment of the amyloid precursor protein, implicated in the pathogenesis of Alzheimer's disease. Its aggregation and accumulation in the brain contribute to the formation of amyloid plaques, a hallmark of the disease.
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
Isotype Control
- CAT
- Product Name
Secondary Antibody
- CAT
- Product Name
See other products for "Clone 8F5"
- CAT
- Product Name
See other products for "Aβ42"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
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| MOB-25-F(E) | Recombinant Anti-human Aβ42 Antibody Fab Fragment | Neut, IF, FuncS | Fab |
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-25-S(P) | Recombinant Anti-human Aβ42 Antibody scFv Fragment | WB, FC, FuncS | scFv |
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| HPAB-0511-WJ-S(P) | Mouse Anti-Aβ42 Recombinant Antibody (clone 3F5); scFv Fragment | ELISA, FC | Mouse scFv |
| HPAB-0586-FY-S(P) | Human Anti-Aβ42 Recombinant Antibody (clone M06); scFv Fragment | DB, ELISA | Human scFv |
| HPAB-2064-FY-S(P) | Human Anti-Aβ42 Recombinant Antibody (clone 8F5); scFv Fragment | Neut, ELISA | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| IAB-B042(A) | Recombinant Anti-human Aβ42 Intrabody [(D-Arg)9] | CO-IP, FuncS | scFv-(D-Arg)9 |
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| IAB-B042(T) | Recombinant Anti-human Aβ42 Intrabody [Tat] | ELISA, Neut, FuncS | scFv-Tat |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-2023-FY-VHH | Camelid Anti-Aβ42 Recombinant Single Domain Antibody (HPAB-2023-FY-VHH) | ELISA | Llama VHH |
| HPAB-2024-FY-VHH | Camelid Anti-Aβ42 Recombinant Single Domain Antibody (HPAB-2024-FY-VHH) | ELISA | Llama VHH |
| HPAB-2025-FY-VHH | Camelid Anti-Aβ42 Recombinant Single Domain Antibody (HPAB-2025-FY-VHH) | ELISA | Llama VHH |
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