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    Afuco™ Anti-Human ACVR2A ADCC Recombinant Antibody, ADCC Enhanced (CAT#: AFC-010CL)

    Anti-ACVR2A ADCC Enhanced Antibody is an ADCC enhanced antibody produced by our Afuco™ platform. Molecules having activin or ActRIIa antagonist activity ("activin antagonists" and "ActRIIa antagonists") can be used to increase bone density, promote bone growth, and/or increase bone strength.

    Specific Inquiry
    • Size:

    • Conjugation:

    • Endotoxin:

    • Purity:

    • Formats:

    • Isotype Switching:

    • Fc Engineering:

    • Modalities:

    Custom Production

    We specialize in custom recombinant antibody production, offering seamless execution from provided sequences to high-quality antibody deliverables, ensuring optimal yield and purity.

    Sequences:
    Isotype :
    Purity :
    Endotoxin :
    Quantity :
    Conjugation :
    Fc Engineering :
    Modalities :
    Other Requirements:
    We require custom production
    • Gene Expression
    • Datasheet
    • MSDS
    • COA
    Subcellular Location and Protein Expression
    Figure 1 IF staining of cell line RH-30
    Figure 1 IF staining of cell line RH-30
    (Immunofluorescent staining of cell line RH-30 shows localization to cytosol.)
    * Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/46997/1150_C7_5_blue_red_green.jpg
    Figure 2 IF staining of cell line RT4
    Figure 2 IF staining of cell line RT4
    (Immunofluorescent staining of cell line RT4 shows localization to cytosol.)
    * Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/46997/1421_G1_4_blue_red_green.jpg
    Figure 3 IHC staining of human rectum
    Figure 3 IHC staining of human rectum
    (Immunohistochemical staining of human rectum shows strong cytoplasmic and membranous positivity in glandular cells.)
    * Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/46997/ihc_selected.jpg
    Normal Tissue
    Figure 4 Cerebral cortex
    Figure 4 Cerebral cortex
    (Endothelial cells
    Staining:Medium
    Intensity: Moderate
    Quantity:>75%
    Location: Cytoplasmic/membranous Neuronal cells
    Staining:High
    Intensity: Strong
    Quantity:>75%
    Location: Cytoplasmic/membranous nuclear
    Neuropil
    Staining:Medium
    Intensity: Moderate
    Quantity:>75%
    Location: Cytoplasmic/membranous)
    * Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/46997/106208_B_7_5.jpg
    Figure 5 Colon
    Figure 5 Colon
    (Endothelial cells
    Staining:Medium
    Intensity: Moderate
    Quantity:>75%
    Location: Cytoplasmic/
    membranous
    Glandular cells
    Staining:Medium
    Intensity: Moderate
    Quantity:>75%
    Location: Cytoplasmic/membranous
    Peripheral nerve/ganglion
    Staining:Medium
    Intensity: Moderate
    Quantity:>75%
    Location: Cytoplasmic/membranous)
    * Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/46997/106208_A_9_3.jpg
    Figure 6 Liver
    Figure 6 Liver
    (Hepatocytes
    Staining:High
    Intensity: Strong
    Quantity: 75%-25%
    Location: Cytoplasmic/membranous)
    * Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/46997/106208_A_7_4.jpg
    Figure 7 Kidney
    Figure 7 Kidney
    (Cells in glomeruli
    Staining:Medium
    Intensity: Moderate
    Quantity: 75%-25%
    Location: Cytoplasmic/membranous
    Cells in tubules
    Staining:High
    Intensity: Strong
    Quantity: 75%-25%
    Location: Cytoplasmic/membranous)
    * Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/46997/106208_A_8_5.jpg
    Figure 8 Testis
    Figure 8 Testis
    (Cells in seminiferous ducts
    Staining:High
    Intensity: Strong
    Quantity:>75%
    Location: Cytoplasmic/membranous
    Leydig cells
    Staining:Medium
    Intensity: Moderate
    Quantity:>75%
    Location: Cytoplasmic/membranous)
    * Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/46997/106208_A_4_6.jpg
    Figure 9 Lymph node
    Figure 9 Lymph node
    (Germinal center cells
    Staining:Medium
    Intensity: Moderate
    Quantity:>75%
    Location: Cytoplasmic/membranous
    Non-germinal center cells
    Staining:Medium
    Intensity: Moderate
    Quantity:>75%
    Location: Cytoplasmic/membranous)
    * Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/46997/106208_A_9_8.jpg

    Specifications

    • Host Species
    • Mouse
    • Derivation
    • Human
    • Type
    • ADCC enhanced antibody
    • Species Reactivity
    • Human
    • Related Disease
    • Bone-related Diseases

    Product Property

    • Purity
    • >95% by HPLC
    • Storage
    • ≤1 year at -20°C.

    Target

    • Alternative Names
    • ACVR2A; activin A receptor, type IIA

    Product Notes

    This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

    • Increased sensitivity
    • Confirmed specificity
    • High repeatability
    • Excellent batch-to-batch consistency
    • Sustainable supply
    • Animal-free production

    See more details about Hi-Affi™ recombinant antibody benefits.

    Downloads

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    Please select product type
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    CAT Product Name Application Type
    TAB-0361CL Anti-Human ACVR2A Recombinant Antibody (APE2990) ELISA, FuncS, Inhib
    TAB-0361CL-S(P) Anti-Human ACVR2A Recombinant Antibody scFv Fragment (APE2990) ELISA, FuncS, Inhib
    TAB-0362CL-S(P) Anti-Human ACVR2A Recombinant Antibody scFv Fragment (APE2991) ELISA, FuncS, Inhib
    TAB-0363CL-S(P) Anti-Human ACVR2A Recombinant Antibody scFv Fragment (APE2665) ELISA, FuncS, Inhib
    TAB-0364CL-S(P) Anti-Human ACVR2A Recombinant Antibody scFv Fragment (APE2666) ELISA, FuncS, Inhib

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