Anti-Human ACVR2A Recombinant Antibody Fab Fragment (APE2990)
CAT#: TAB-0361CL-F(E)
The anti- ActRII antibody specifically target an activin receptor I, which is related to the regulation of muscle growth. By effectively neutralizing the ActllR activity, the specific antibody can be used in the treatment of muscle wasting, and in the regulation of muscle growth.
Gene Expression
Subcellular Location and Protein Expression
Figure 1 IF staining of cell line RH-30
Immunofluorescent staining of cell line RH-30 shows localization to cytosol.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/46997/1150_C7_5_blue_red_green.jpg
Subcellular Location and Protein Expression
Figure 2 IF staining of cell line RT4
Immunofluorescent staining of cell line RT4 shows localization to cytosol.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/46997/1421_G1_4_blue_red_green.jpg
Subcellular Location and Protein Expression
Figure 3 IHC staining of human rectum
Immunohistochemical staining of human rectum shows strong cytoplasmic and membranous positivity in glandular cells.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/46997/ihc_selected.jpg
Normal Tissue
Figure 4 Cerebral cortex
Endothelial cells
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous Neuronal cells
Staining:High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous nuclear
Neuropil
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/46997/106208_B_7_5.jpg
Normal Tissue
Figure 5 Colon
Endothelial cells
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/
membranous
Glandular cells
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
Peripheral nerve/ganglion
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/46997/106208_A_9_3.jpg
Normal Tissue
Figure 6 Liver
Hepatocytes
Staining:High
Intensity: Strong
Quantity: 75%-25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/46997/106208_A_7_4.jpg
Normal Tissue
Figure 7 Kidney
Cells in glomeruli
Staining:Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous
Cells in tubules
Staining:High
Intensity: Strong
Quantity: 75%-25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/46997/106208_A_8_5.jpg
Normal Tissue
Figure 8 Testis
Cells in seminiferous ducts
Staining:High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
Leydig cells
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/46997/106208_A_4_6.jpg
Normal Tissue
Figure 9 Lymph node
Germinal center cells
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
Non-germinal center cells
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/46997/106208_A_9_8.jpg
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Specifications
- Host Species
- Human
- Specificity
- Human
- Clone
- APE2990
- Related Disease
- ActRII-mediated, muscle wasting disorder
Target
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Downloadable Resources
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
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See other products for "Clone APE2990"
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See other products for "ACVR2A"
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-0361CL | Anti-Human ACVR2A Recombinant Antibody (APE2990) | ELISA, FuncS, Inhib | |
| TAB-0362CL | Anti-Human ACVR2A Recombinant Antibody (APE2991) | ELISA, FuncS, Inhib | |
| TAB-0363CL | Anti-Human ACVR2A Recombinant Antibody (APE2665) | ELISA, FuncS, Inhib | |
| TAB-0364CL | Anti-Human ACVR2A Recombinant Antibody (APE2666) | ELISA, FuncS, Inhib | |
| TAB-0362CL-F(E) | Anti-Human ACVR2A Recombinant Antibody Fab Fragment (APE2991) | ELISA, FuncS, Inhib |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-0653CLV | Mouse Anti-ACVR2A Recombinant Antibody (TAB-0653CLV) | ELISA | Mouse IgG |
| TAB-0653CLV-F(E) | Mouse Anti-ACVR2A Recombinant Antibody; Fab Fragment (TAB-0653CLV-F(E)) | ELISA | Mouse Fab |
| TAB-0653CLV-S(P) | Mouse Anti-ACVR2A Recombinant Antibody; scFv Fragment (TAB-0653CLV-S(P)) | ELISA | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-0427MZ | Mouse Anti-ACVR2A Recombinant Antibody (clone 250/2) | IP, WB | Mouse IgG1 |
| HPAB-0134-FY | Mouse Anti-ACVR2A Recombinant Antibody (HPAB-0134-FY) | ELISA, Neut | Mouse IgG |
| VS13-YC21 | Rabbit Anti-ACVR2A Recombinant Antibody (VS13-YC21) | WB | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-0063 | Hi-Affi™ Rabbit Anti-ACVR2A Recombinant Antibody (clone DS63AB) | WB | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0134-FY-S(P) | Mouse Anti-ACVR2A Recombinant Antibody; scFv Fragment (HPAB-0134-FY-S(P)) | ELISA | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0134-FY-F(E) | Mouse Anti-ACVR2A Recombinant Antibody; Fab Fragment (HPAB-0134-FY-F(E)) | ELISA | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-YC626 | Recombinant Anti-ACVR2A Vesicular Antibody, EV Displayed (VS-0425-YC626) | ELISA, FC, Neut, Cell-uptake |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY137 | Anti-ACVR2A Immunohistochemistry Kit | IHC | |
| VS-0525-XY138 | Anti-Human ACVR2A Immunohistochemistry Kit | IHC | |
| VS-0525-XY139 | Anti-Mouse ACVR2A Immunohistochemistry Kit | IHC |
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