Anti-Human ADAMTS5 Recombinant Antibody (12F4.1H7) (CAT#: TAB-0684CLV)

The anti-ADAMTS5 antibody 12F4.1H7 targets ADAMTS5 that is kind of aggrecanases of which the activities can result in the degradation of the cartilage matrix. By inhibiting ADAMTS5 and thereby reducing the breakdown of extracellular matrix aggrecan in cartilage and other tissues, 12F4.1H7 can be used in the treatment of disease of cartilage.


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FuncS

Figure 1 ADAMTS-4 and ADAMTS-5 mAbs specifically bind to and potently inhibit aggrecanase activity.

Figure 1 ADAMTS-4 and ADAMTS-5 mAbs specifically bind to and potently inhibit aggrecanase activity.

Functional potency of ADAMTS-5 mAbs and non-selective small molecule (GSK579149) is quantified vs isotype controls (not shown) by measuring percent inhibition of selective aggrecanase-mediated ARGS neoepitope formation from purified bovine aggrecan substrate.

Larkin, J., Lohr, T. A., Elefante, L., Shearin, J., Matico, R., Su, J. L., ... & Tran, P. B. (2015). Translational development of an ADAMTS-5 antibody for osteoarthritis disease modification. Osteoarthritis and cartilage, 23(8), 1254-1266.


Specifications

  • Immunogen
  • ADAMTS4, ADAMTS5
  • Host Species
  • Mouse
  • Specificity
  • Human
  • Species Reactivity
  • Cross-react with cynomolgus and canine ADAMTS5
  • Clone
  • 12F4.1H7
  • Applications
  • FuncS
  • Related Disease
  • Diseases of cartilage

Applications

  • Application Notes
  • The ADAMTS5 antibody has been reported in applications of Functional Assay.

Target

  • Alternative Names
  • ADAMTS5; ADAM metallopeptidase with thrombospondin type 1 motif, 5; ADMP-2; ADAM-TS5; ADAMTS-5; ADAMTS11; ADAM-TS 5; ADAMTS-11; ADAM-TS 11

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Downloads

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Recombinant Antibody

CAT Product Name Application Type
MOB-39 Recombinant Anti-human ADAMTS5 Antibody ELISA, WB, Dot, FuncS IgG
MHH-39 Recombinant Human Anti-human ADAMTS5 Antibody ELISA, WB, FC, FuncS IgG
PABL-005 Mouse Anti-ADAMTS5 Recombinant Antibody (clone 7B4) Inhib, WB, ELISA, FuncS Mouse IgG1
PABL-391 Mouse Anti-ADAMTS5 Recombinant Antibody (PABL-391) WB, ELISA, FuncS Mouse IgG2c
MOB-142CQ Mouse Anti-ADAMTS5 Recombinant Antibody (clone CBLS-195) ELISA, WB, IP Mouse IgG2b

Mouse Antibody

CAT Product Name Application Type
TAB-0685CLV Anti-Human ADAMTS5 Recombinant Antibody (7B4.1E11) FuncS

Chimeric Antibody

CAT Product Name Application Type
TAB-0692CLV Anti-Human ADAMTS5 Recombinant Antibody (7B4) ICC, ELISA Chimeric antibody (mouse/human)

Humanized Antibody

CAT Product Name Application Type
TAB-0693CLV Humanized Anti-Human ADAMTS5 Recombinant Antibody (12F4.1H7) FuncS Humanized antibody

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For Research Use Only. Not For Clinical Use.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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