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    ADAMTS5

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    For Research Use Only. Not For Clinical Use.


    This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The encoded preproprotein is proteolytically processed to generate the mature enzyme. This enzyme contains two C-terminal TS motifs and functions as an aggrecanase that cleaves aggrecan, a major proteoglycan of cartilage, and may mediate cartilage destruction in osteoarthritis. [provided by RefSeq, Feb 2016]
    Protein class

    Cancer-related genes

    Predicted location

    Secreted

    Single cell type specificity

    Cell type enhanced (Skeletal myocytes, Fibroblasts, Endometrial stromal cells, Leydig cells, Smooth muscle cells, Breast myoepithelial cells)

    Immune cell specificity

    Not detected in immune cells

    Cell line specificity

    Cell line enhanced (ASC diff, ASC TERT1, fHDF/TERT166, RH-30, U-87 MG)

    Molecular function

    Hydrolase, Metalloprotease, Protease

    More Types Infomation
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