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ADAMTS5

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Anti-ADAMTS5 Recombinant Antibody Products

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For Research Use Only. Not For Clinical Use.


This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The enzyme encoded by this gene contains two C-terminal TS motifs and functions as aggrecanase to cleave aggrecan, a major proteoglycan of cartilage.
Protein class

Cancer-related genes

Predicted location

Secreted

Single cell type specificity

Cell type enhanced (Skeletal myocytes, Fibroblasts, Endometrial stromal cells, Leydig cells, Smooth muscle cells, Breast myoepithelial cells)

Immune cell specificity

Not detected in immune cells

Cell line specificity

Cell line enhanced (ASC diff, ASC TERT1, fHDF/TERT166, RH-30, U-87 MG)

Molecular function

Hydrolase, Metalloprotease, Protease

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