Anti-AFP immunotoxin 80G (IgG)-Gel
CAT#: AGTO-G072G
This immunotoxin was achieved by conjugating/fusing the Anti-AFP monoclonal antibody to gelonin. It was expressed in CHO and purified with affinity chromatography. The immunotoxin selectively binds to tumor cells. Once bind, the toxin enters cells by receptor-mediated endocytosis. Then, gelonin, like abrin and ricin, inhibits protein synthesis by damaging the 60S subunit of mammalian ribosomes. It was designed for treating hepatic carcinoma.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line Hep G2
Immunofluorescent staining of human cell line Hep G2 shows localization to cytosol & the Golgi apparatus.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10607/1816_H10_5_selected.jpg
Subcellular Location
Figure 2 IHC staining of human placenta
Immunohistochemical staining of human placenta shows strong positivity in plasma.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10607/25809_A_2_7_selected.jpg
RNA Expression
Figure 3 RNA cell line category: Cell line enriched (Hep G2)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000081051-AFP
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Specifications
- Host Species
- Mouse
- Species Reactivity
- Human
- Clone
- 80G
- Molecule Class
- IgG-Gel
- Toxin Description
- Gelonin is a glycoprotein (M.W. approximately 29-30,000 Kd) purified from the seeds of Gelonium multiforum and belongs to a class of potent ribosomal-inactivating plant toxins. Gelonin, like abrin and ricin, inhibits protein synthesis by damaging the 60S subunit of mammalian ribosomes.
- Applications
- This product is suitable for use in cytotoxicity assay, functional assay and immunotherapy.
- Related Disease
- Hepatic carcinoma
Target
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
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- CAT
- Product Name
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| CAT | Product Name | Application | Type |
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| HPAB-0297-FY-S(P) | Mouse Anti-AFP Recombinant Antibody scFv Fragment (HPAB-0297-FY-S(P)) | ELISA, IF, IHC | Mouse scFv |
| HPAB-0298-FY-S(P) | Mouse Anti-AFP Recombinant Antibody scFv Fragment (HPAB-0298-FY-S(P)) | ELISA, IF, IHC | Mouse scFv |
| CAT | Product Name | Application | Type |
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| FAMAB-0017-YC-F(E) | Mouse Anti-AFP Recombinant Antibody (clone AF5); Fab Fragment | WB | Mouse Fab |
| HPAB-0296-FY-F(E) | Mouse Anti-AFP Recombinant Antibody Fab Fragment (HPAB-0296-FY-F(E)) | ELISA, IF, IHC | Mouse Fab |
| HPAB-0297-FY-F(E) | Mouse Anti-AFP Recombinant Antibody Fab Fragment (HPAB-0297-FY-F(E)) | ELISA, IF, IHC | Mouse Fab |
| HPAB-0298-FY-F(E) | Mouse Anti-AFP Recombinant Antibody Fab Fragment (HPAB-0298-FY-F(E)) | ELISA, IF, IHC | Mouse Fab |
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| AFC-TAB-713 | Afuco™ Anti-AFP ADCC Recombinant Antibody, ADCC Enhanced | IF, IP, Neut, FuncS, ELISA, FC | ADCC enhanced antibody |
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| ZG-0771F | Mouse Anti-AFP Recombinant Antibody (clone C3) | IHC | Mouse IgG2a |
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS3-XY30 | Mouse Anti-AFP Recombinant Antibody (clone 143CT50.11.8) | WB | Mouse IgM |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0724-YC295 | AbPlus™ Anti-AFP Magnetic Beads (VS-0724-YC295) | IP, Protein Purification |
| CAT | Product Name | Application | Type |
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| VS-0924-YC15 | Mouse Anti-AFP Recombinant Antibody (VS-0924-YC15) - Cancer Stem Cell Marker | IHC, WB | Mouse IgG2a |
| VS-0924-YC17 | Rabbit Anti-AFP Antibody (VS-0924-YC17) - Cancer Stem Cell Marker | IHC, WB | Rabbit IgG |
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| VS-1024-XY10 | Mouse Anti-NHP AFP Recombinant Antibody (clone SPM334) | IHC, ICC, FC | Mouse IgG2a, kappa |
| CAT | Product Name | Application | Type |
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| VS-0325-XY55 | Anti-AFP Immunohistochemistry Kit | IHC | |
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