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Anti-AFP immunotoxin 80G (IgG)-Gel (AGTO-G072G)

This immunotoxin was achieved by conjugating/fusing the Anti-AFP monoclonal antibody to gelonin. It was expressed in CHO and purified with affinity chromatography. The immunotoxin selectively binds to tumor cells. Once bind, the toxin enters cells by receptor-mediated endocytosis. Then, gelonin, like abrin and ricin, inhibits protein synthesis by damaging the 60S subunit of mammalian ribosomes. It was designed for treating hepatic carcinoma.      
Datasheet
Specifications
Host
Mouse
Species Reactivity
Human
Clone
80G
Molecule Class
IgG-Gel
Toxin Description
Gelonin is a glycoprotein (M.W. approximately 29-30,000 Kd) purified from the seeds of Gelonium multiforum and belongs to a class of potent ribosomal-inactivating plant toxins. Gelonin, like abrin and ricin, inhibits protein synthesis by damaging the 60S subunit of mammalian ribosomes.
Applications
This product is suitable for use in cytotoxicity assay, functional assay and immunotherapy.
Related Disease
Hepatic carcinoma
Target
Alternative Names
AFP; alpha-fetoprotein; AFPD; FETA; HPAFP; alpha-fetoglobulin; alpha-1-fetoprotein; Gelonin
Entrez Gene ID
174
UniProt ID
P02771

For lab research use only, not for diagnostic, therapeutic or any in vivo human use.

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Anti-AFP immunotoxin 80G (F (ab')2)-Gel    ( AGTO-G071G )
Recombinant Anti-Human AFP Antibody Fab Fragment    ( MOB-1278z-F(E) )
Recombinant Mouse Anti-AFP Antibody scFv Fragment (cImmu31)    ( HPAB-0317-CN-S(P) )
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Recombinant Mouse Anti-AFP Antibody (AF5)    ( FAMAB-0017YC )
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