Afuco™ Anti-Human AGER ADCC Recombinant Antibody, ADCC Enhanced (CAT#: AFC-024CL)
Anti-AGER ADCC Enhanced Antibody is an ADCC enhanced antibody produced by our Afuco™ platform. These antibodies have the ability to inhibit the binding of RAGE to its various ligands. The antibodies or portions thereof of described in the present application are useful for treating a disease or disorder characterized by or induced by pathophysiological ligands of RAGE, for example missfolded proteins like amyloid β and advanced glycation-end-products.
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Custom Production
We specialize in custom recombinant antibody production, offering seamless execution from provided sequences to high-quality antibody deliverables, ensuring optimal yield and purity.
We require custom production
Subcellular Location
Normal Tissue
RNA Expression
Figure 1 IF staining of human cell line MCF7
(Immunofluorescent staining of human cell line MCF7 shows localization to nucleoli fibrillar center & cell junctions.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/64436/1232_G12_3_selected.jpg
(Immunofluorescent staining of human cell line MCF7 shows localization to nucleoli fibrillar center & cell junctions.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/64436/1232_G12_3_selected.jpg
Figure 2 Lung
(Alveolar cells type I
Staining: High
Intensity: Strong
Quantity:>75%
Alveolar cells type II
Staining: Medium
Intensity: Strong
Quantity: <25%)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/69474/168057_A_2_4.jpg
(Alveolar cells type I
Staining: High
Intensity: Strong
Quantity:>75%
Alveolar cells type II
Staining: Medium
Intensity: Strong
Quantity: <25%)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/69474/168057_A_2_4.jpg
Figure 3 RNA cell line category: Cell line enhanced (HEK93, JURKAT, RPTEC TERT1, U-266/70, U-266/84)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000204305-AGER
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000204305-AGER
Specifications
- Host Species
- Humanized
- Derivation
- Humanized
- Type
- ADCC enhanced antibody
- Species Reactivity
- Human
- Related Disease
- Inflammatory Diseases
Product Property
- Purity
- >95% by HPLC
- Storage
- Short Term Storage: 4°C
Long Term Storage: -20°C
Target
- Alternative Names
- AGER; advanced glycosylation end product-specific receptor; RAGE; RAGE isoform sRAGE-delta; RAGE isoform NtRAGE-delta; receptor for advanced glycation end-products variant 20
- Gene ID
- 177
- UniProt ID
- B4DNX3
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
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Extracellular Vesicle (EV) Antibody Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-44-F(E) | Recombinant Anti-human AGER Antibody Fab Fragment | ELISA, Nert, FuncS | Fab |
| PSBZ-175 | Rabbit Anti-AGER Recombinant Antibody (clone H4); scFv Fragment | ELISA, Neut | Rabbit scFv |
| HPAB-0086-YC-F(E) | Mouse Anti-AGER Recombinant Antibody Fab Fragment (HPAB-0086-YC-F(E)) | ELISA, RIA, IHC, Neut | Mouse Fab |
| HPAB-N0016-YC-F(E) | Human Anti-AGER Recombinant Antibody; Fab Fragment (HPAB-N0016-YC-F(E)) | ELISA | Humanized Fab |
| HPAB-1476-FY-S(P) | Mouse Anti-AGER Recombinant Antibody; scFv Fragment (HPAB-1476-FY-S(P)) | ELISA | Mouse scFv |
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