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    Hi-Affi™ Rabbit Anti-ASPH Recombinant Antibody (clone DS269AB) (CAT#: MOR-0269)

    Recombinant Rabbit anti-ASPH monoclonal antibody for WB, IHC-P, ICC/IF, FC, excellent for producing superior results. Hi-Affi™ antibodies are developed from different sources, such as B cells of immunized animals, hybridoma, phage display library. The application of recombinant technology avoids the traditional ascitic fluid approach, which achieves the antibody generation in a humane way with much larger scale, greater specificity and sensitivity, and not susceptible to cell-line drift or lot-to-lot variation.

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    • Size:

    • Conjugation:

    • Endotoxin:

    • Purity:

    • Formats:

    • Isotype Switching:

    • Fc Engineering:

    • Modalities:

    Custom Production

    We specialize in custom recombinant antibody production, offering seamless execution from provided sequences to high-quality antibody deliverables, ensuring optimal yield and purity.

    Sequences:
    Isotype :
    Purity :
    Endotoxin :
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    Conjugation :
    Fc Engineering :
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    Other Requirements:
    We require custom production
    • Gene Expression
    • Datasheet
    • MSDS
    • COA
    Subcellular Location
    Figure 1 IF staining of human cell line HeLa
    Figure 1 IF staining of human cell line HeLa
    (Immunofluorescent staining of human cell line HeLa shows localization to endoplasmic reticulum.)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/55161/if_selected.jpg
    Figure 2 IF staining of human cell line A549
    Figure 2 IF staining of human cell line A549
    (Immunofluorescent staining of human cell line A549 shows localization to endoplasmic reticulum.)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/59303/1873_A7_2_selected.jpg
    Normal Tissue
    Figure 3 IHC staining of human cerebral cortex
    Figure 3 IHC staining of human cerebral cortex
    (Immunohistochemical staining of human cerebral cortex shows strong cytoplasmic positivity in astrocytes.)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/59303/ihc_selected.jpg
    Figure 4 Cerebral cortex
    Figure 4 Cerebral cortex
    (Glial cells
    Staining: High
    Intensity: Strong
    Quantity: 75%-25%
    Location: Cytoplasmic/membranous
    Neuropil
    Staining: Medium
    Intensity: Moderate
    Quantity:>75%
    Location: Cytoplasmic/membranous)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/59303/133131_B_9_5.jpg
    Figure 5 Colon
    Figure 5 Colon
    (Glandular cells
    Staining: High
    Intensity: Strong
    Quantity: 75%-25%
    Location: Cytoplasmic/membranous
    Peripheral nerve/ganglion
    Staining: Medium
    Intensity: Moderate
    Quantity: 75%-25%
    Location: Cytoplasmic/membranous)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/59303/133131_A_7_3.jpg
    Figure 6 Pancreas
    Figure 6 Pancreas
    (Pancreatic endocrine cells
    Staining: High
    Intensity: Strong
    Quantity: 75%-25%
    Location: Cytoplasmic/membranous)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/59303/133131_A_2_3.jpg
    Figure 7 Kidney
    Figure 7 Kidney
    (Cells in tubules
    Staining: Medium
    Intensity: Moderate
    Quantity: 75%-25%
    Location: Cytoplasmic/membranous)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/59303/133131_A_8_5.jpg
    Figure 8 Testis
    Figure 8 Testis
    (Leydig cells
    Staining: High
    Intensity: Strong
    Quantity:>75%
    Location: Cytoplasmic/membranous)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/59303/133131_A_6_6.jpg
    RNA Expression
    Figure 9 RNA cell line category: Cell line enhanced (U-87 MG)
    Figure 9 RNA cell line category: Cell line enhanced (U-87 MG)
    (Cell lines ordered by descending RNA expression order.)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000198363-ASPH

    Specifications

    • Immunogen
    • Synthetic peptide (the amino acid sequence is considered to be commercially sensitive) within Human Aspartate beta hydroxylase aa 250-350 (Cysteine residue). The exact sequence is proprietary.
    • Host Species
    • Rabbit
    • Derivation
    • Phage display library screening
    • Type
    • Rabbit IgG
    • Species Reactivity
    • Human
    • Clone
    • DS269AB
    • Applications
    • WB, IHC-P, IF, FC
    • Conjugate
    • Unconjugated

    Product Property

    • Purification
    • Purified with Absolute Mag™ Protein A Agarose
    • Purity
    • >95% as determined by analysis by SDS-PAGE
    • Format
    • Liquid
    • Storage
    • Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

    Target

    • Alternative Names
    • Aspartate Beta-Hydroxylase 2; Peptide-Aspartate Beta-Dioxygenase; ASP Beta-Hydroxylase; Junctate; Junctin; Humbug; BAH; Aspartyl/Asparaginyl-Beta-Hydroxylase; Cardiac Junctin; EC 1.14.11.16; A Beta H-J-J; CASQ2BP1; FDLAB; HAAH; JCTN; AAH

    Related Resources

    • Citations

    Babich, Michael, et al. "Labyrinthin: A distinct pan-adenocarcinoma diagnostic and immunotherapeutic tumor specific antigen." Heliyon 8.3 (2022). https://doi.org/10.1016/j.heliyon.2022.e08988

    This article distinguishes labyrinthin as a unique tumor-specific antigen (TSA) exclusively expressed on the surface of adenocarcinoma cells, differentiating it from the related intracellular protein aspartyl/asparaginyl β-hydroxylase (ASPH). Through immunohistochemistry, FACS analysis, confocal microscopy, and cell transfection studies, the researchers demonstrate that labyrinthin not only serves as a marker but appears functional in the cancer phenotype, with its expression promoting cancerous characteristics in normal cells and its inhibition normalizing cancer cell morphology.
    Creative Biolabs provided recombinant human IgG1 (CAT#: MHH-78-F(E)) antibodies that bind to ASPH in HEK 293 cells as well as polyclonal antibodies (CAT#: MOR-0269) targeting ASPH amino acids 250-350. These antibodies helped the researchers distinguish between ASPH and labyrinthin binding patterns, clarifying the cellular localization and expression patterns of these proteins and establishing labyrinthin as a distinct cell-surface target for potential adenocarcinoma immunotherapy approaches.

    More Infomation

    Product Notes

    This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

    • Increased sensitivity
    • Confirmed specificity
    • High repeatability
    • Excellent batch-to-batch consistency
    • Sustainable supply
    • Animal-free production

    See more details about Hi-Affi™ recombinant antibody benefits.

    Downloads

    Download resources about recombinant antibody development and antibody engineering to boost your research.

    See other products for "ASPH"

    Select a product category from the dropdown menu below to view related products.
    Please select product type
    IgG Antibody Products Fab Antibody Products ScFv Antibody Products IHC Kit and Antibody Products: Precision Tools for Immunohistochemistry
    CAT Product Name Application Type
    MOB-78 Recombinant Anti-human ASPH Antibody WB, FC, FuncS IgG
    MHH-78 Recombinant Human Anti-human ASPH Antibody IF, FACS, FuncS IgG

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